Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 33 for “"Hyperproliferation"”.
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UNDERSTANDING LAMIN A/C AND ITS ROLES IN DISEASE PATHOLOGIES
… LMNA ALTERED EXPRESSION OF GENES ASSOCIATED WITH HYPERPROLIFERATION AND MALIGNANT TRANSFORMATION. THESE RESULTS INDICATE THAT A-TYPE LAMINS REGULATE CELL PROLIFERATION. USING LMNA AND LAMIN B RECEPTOR (LBR) KNOCKOUT MICE, WE SHOW ABSENCE OF BOTH PROTEINS RESULTS IN THE DISPLACEMENT OF PERIPHERAL …
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Angiogenetische Faktoren bei Psoriasis, Ulcus cruris venosum und Dermatoliposklerose
… Normalhaut. Wir vermuten, dass die psoriatische Hyperproliferation zu einem Mehrbedarf des Gewebes an Sauerstoff und Nährstoffen führt, der durch eine gesteigerte Gefäßneubildung und Gefäßreifung gedeckt werden kann. In Biopsien aus Ulcus cruris venosum detektierten wir in der tiefen Dermis und …
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MAP kinase phosphatase-2 in vascular smooth cell muscle function
… often driven by vascular smooth muscle cell hyperproliferation. A major mechanism by which smooth muscle cell proliferation occurs involves ligand-induced activation of MAP kinase signalling (Schad et al., 2011). MAP kinases have been noteworthy but troublesome targets in cardiovascular …
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Δnp63 Regulates A Complex Network of Target Genes In Limb and Epidermal Development
… display wound-healing defects that result from hyperproliferation of dermal stem cells. That results in premature depletion of these cells, which are necessary for wound repair, that indicates TAp63 plays a role in dermal/epidermal maintenance. To study the role of ΔNp63, I generated a ΔNp63-/- …
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Multinuclear and Mononuclear Polyploidy in the Drosophila Hindgut and Heart
… tissue physiology to likelihood of cancers and hyperproliferation to the response to stress and tissue damage. These two decisions, to be small or large and to be distinct (mononucleated) or joined (multinucleated), and, especially, the interaction between these choices are poorly understood. In …
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Effects of oncogenic Ras and p38 mitogen-activated protein kinase on the adhesion of normal human cells
… of oncogenic Ras signaling induced cellular hyperproliferation, whereas a high level of signaling induced cellular senescence. A growing body of literature links loss of p38 mitogen-activated protein kinase (MAPK) activity with the promotion of Ras-induced transformation in murine cells. …
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Translational mechanisms of stem cell fate regulation in epidermal oncogene tolerance
… find that oncogenic RAS-induced progenitor cell hyperproliferation is coordinated with differentiation to restrain aberrant growth and preserve epidermal development. We uncover a novel translation mechanism mediated by initiation factor eIF2B5 that co-regulates RAS proliferation and …
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Exploring the role of the arginine-methylation writer-reader pair PRMT5/SND1 in JAK2-mutant myeloproliferative neoplasms
… are a hematopoietic disease characterized by hyperproliferation of cells of the myeloid lineage for which current therapeutic options are limited. Discovered in 2005, the JAK2V617F mutation is the most common driver mutation in BCR-ABL negative MPNs, resulting in constitutive activation of the …
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SURVIVING UNDER PRESSURE: TRANSLATIONAL REWIRING IN RESPONSE TO MECHANICAL STIMULI
… of high mechanical stress in the context of hyperproliferation and increased cellular tension is the reduction in cell volume, that holds the potential to impact cellular density. Both cell size and density homeostasis are integral features of healthy tissues, intricately linked to the …
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Expression and function of small RNAs in normal and psoriatic skin
… inflammatory skin disease characterized by hyperproliferation and altered differentiation of keratinocytes, and infiltration of activated immune cells in the epidermis. Array based genome-wide expression studies by our lab and others have revealed over 1,300 alterations in mRNA transcript …
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Identifikation und funktionelle Analyse von Xdach1 und Xeya3 als morphogenetische Faktoren der Kopfentwicklung von Xenopus laevis
… führt ein Funktionsgewinn von Xeya3 zur Hyperproliferation neuraler Vorläuferzellen und einer daraus folgenden Neoplasie von Gehirn- und Retinagewebe. In diesem Zusamenhang verursacht die Inaktivierung einer intrinsischen Phosphatase-Aktivität von Xeya3 eine deutliche Aktivitätssteigerung …
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Helicobacter Pylori aktiviert den Transkriptionsfaktor AP-1 über mitogen-aktivierte Proteinkaskaden und induziert die Protoonkogene c-fos und c-jun
… der chronischen Infektion mit H.pylori wie die Hyperproliferation der Magenschleimhaut sowie die neoplastische Transformation besser verstanden werden.
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Epigenetic regulation by 5-hydroxymethylcytosine in atopic dermatitis and psoriasis and its implications for epidermal stem cell behavior
… hyperplasia of the epidermis, suggesting a hyperproliferation of keratinocytes and dysregulation of epidermal stem cells. Therefore, we are interested in how the relationship between 5-hmC level and KSC activity might contribute to the pathogenesis of these diseases. The most important …
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ONCOGENE-INDUCED ALTERED DNA REPLICATION DYNAMICS
… of NOX4 and ROS in mediating oncogene-induced hyperproliferation. Polycomb repressive complexes (PRCs) repress genes involved in development, proliferation and differentiation by EZH2-mediated H3K27 trimethylation. Recent independent studies revealed a more direct PRCs role on S phase …
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The Role of Interleukin-10 Family Members in Inflammatory Skin Diseases. Understanding the mechanism of action of interferon lambda and interleukin-22 on human primary keratinocytes and dermal fibroblasts with a focus on healing responses in inflammatory skin diseases
… impact on normal wound repair, epidermal hyperproliferation and prevention of fibrosis. This work focussed on understanding the regulation and functional impact of IL-22 and IFNλ on skin cells. The counter-regulatory effect of IL-22 on the activities of IFNλ was assessed through downstream …
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Ethanol-induced formation of colorectal tumours and precursors in a mouse model of Lynch syndrome
… led to large intestinal mucosal epithelial hyperproliferation and adenoma formation in 65% (15/23) mice and, in some cases, invasive adenocarcinoma (5/23 mice, 21.7%) within 6 months (mostly in the proximal and mid-colon), compared with 0% (0/23 mice) at 6 months and only one colonic tumour …
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Low-Density Lipoprotein Receptors in Signaling Modulation and Development
… vivo, the LRP1 knockout leads to a bone-derived hyperproliferation with formation of tumors at the epiphysis. The in vitro experiments are supporting evidence, combined with previously published literature, to imply the LRP1/PDGF receptor pathway.
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Preclinical Investigation of Mitochondrial Fission Inhibitors in Pulmonary Arterial Hypertension and Non-Small Cell Lung Cancer
… and Drpitor1a, previously shown to reduce NSCLC hyperproliferation in vitro and ex vivo, can prevent PAH progression in vivo. Methods & Results: Only Drpitor1a was found to inhibit DRP1's GTPase activity in inorganic phosphate assays. While Compound 6 did not inhibit GTPase activity under the …
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Ubiquitination of EpoR and p85 in Ligand Induced EpoR Down-Regulation
… to excessive Epo signaling and erythroid hyperproliferation in PFCP.
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Targeting Akt/Mtor Signaling Pathways During Murine Skin Tumor Promotion and The Impact of Dietary Energy Balance Manipulation
… was analyzed and drastic decreases in epidermal hyperproliferation and hyperplasia were found. Rapamycin also inhibited dermal inflammatory cell infiltration in a dose-dependent manner. Both compounds also blocked or attenuated TPA-induced signaling through epidermal mTORC1 as well as several …
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