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Showing 1 to 5 of 5 for “"Hyperpolarized pyruvate"”.
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Novel Simulation to Avoid Bias In Measurement of Hyperpolarized Pyruvate: Demonstrated In Phantom and In Vivo
… nuclear polarization creates a transient hyperpolarized nuclear state that can dramatically increase the signal detected by magnetic resonance imaging. This signal increase allows real-time spectroscopic imaging of specific metabolites <em>in vivo </em>by magnetic resonance. Real-time …
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Identifying The Immune Related Metabolic Properties of Pancreatic Cancer Using Nuclear Magnetic Resonance Spectroscopy and Dynamic Magnetic Resonance Spectroscopic Imaging With Hyperpolarized Pyruvate
… the inefficient process of glycolysis in which pyruvate is ultimately converted into lactate. Thus, by hyperpolarizing <sup>13</sup>C-labelled pyruvate, one can spectroscopically observe the conversion of pyruvate to lactate in real time and quantify a tumor’s glycolytic conversion flux <em>in …
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An Automated Syringe Pump System For Improving The Reproducibility of Dynamic Hyperpolarized Mri Phantoms
… FOR IMPROVING THE REPRODUCIBILITY OF DYNAMIC HYPERPOLARIZED MRI PHANTOMS</p> <p>Harlee Grace Harrison, B.S.</p> <p>Advisory Professor: James Bankson, Ph.D.</p> <p>Magnetic Resonance Imaging (MRI) is a powerful tool in the diagnosis of cancer due to its ability to provide good soft tissue …
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Imaging Metabolic Signatures in High Grade Serous Ovarian Cancer
… has demonstrated the feasibility of imaging hyperpolarized <sup>13</sup>C pyruvate metabolism in ovarian cancer and has demonstrated inter and intra-tumoural metabolic heterogeneity, where metabolic differences were observed between patients and between different tumour deposits within the …
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Novel approaches to MRI of glioma
… non-invasive assessment of the metabolism of hyperpolarized (HP) 13C-labelled molecules in vivo, such as the exchange of [1-13C]pyruvate to [1-13C]lactate in tumours (Warburg effect). Part of my PhD has focused on developing and translating HP [1-13C]pyruvate MRI to explore metabolic …