Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"Hyperpolarized Magnetic Resonance"”.
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Investigating The Metabolic Progression of Glioblastoma With Hyperpolarized Magnetic Resonance
… was to determine whether metabolic imaging with hyperpolarized magnetic resonance spectroscopy (MRS) could detect changes in tumor progression more rapidly than conventional anatomic magnetic resonance imaging (MRI) in patient-derived GBM murine models. To comprehensively capture the dynamic …
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Leveraging Bioorthogonal Chemistry for Hyperpolarized Magnetic Resonance and Metal Uncaging
… of imaging and metal uncaging. We first consider hyperpolarized magnetic resonance, a powerful tool in clinical and biochemical imaging that suffers from short signal lifetimes, which are typically less than a minute for many common molecular probes. Bioorthogonal handles such as azides and …
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Sensitivity and Specificity of Detecting Premalignant Pancreatic Lesions by Hyperpolarized Magnetic Resonance
… a non-invasive imaging modality called hyperpolarized magnetic resonance (HP MR) metabolic imaging. HP MR increases the signal of conventional MRI by over 10,000-fold and can interrogate the dynamic metabolic flux (lactate-to-pyruvate ratio) <em>in vivo</em> in real time. Concurrently, …
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Hyperpolarized Carbon-13 Magnetic Resonance Measurements of Tissue Perfusion and Metabolism
<p>Hyperpolarized Magnetic Resonance Imaging (HP MRI) is an emerging modality that enables non-invasive interrogation of cells and tissues with unprecedented biochemical detail. This technology provides rapid imaging measurements of the activity of a small quantity of molecules with a strongly …
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Novel Simulation to Avoid Bias In Measurement of Hyperpolarized Pyruvate: Demonstrated In Phantom and In Vivo
… nuclear polarization creates a transient hyperpolarized nuclear state that can dramatically increase the signal detected by magnetic resonance imaging. This signal increase allows real-time spectroscopic imaging of specific metabolites <em>in vivo </em>by magnetic resonance. Real-time …
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Targeting Metabolic Adaptations to Anti-Angiogenic Therapy In Ovarian Cancer
… conversion of pyruvate to lactate as assessed by hyperpolarized magnetic resonance spectroscopy. Furthermore, GLSi therapy initiated after the emergence of AVA resistance restored sensitivity to AVA therapy as evidenced by a reduction in tumor volume and a prolongation of survival of the …