Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"Hyperpolarized MRI"”.
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An Automated Syringe Pump System For Improving The Reproducibility of Dynamic Hyperpolarized Mri Phantoms
… FOR IMPROVING THE REPRODUCIBILITY OF DYNAMIC HYPERPOLARIZED MRI PHANTOMS</p> <p>Harlee Grace Harrison, B.S.</p> <p>Advisory Professor: James Bankson, Ph.D.</p> <p>Magnetic Resonance Imaging (MRI) is a powerful tool in the diagnosis of cancer due to its ability to provide good soft tissue …
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Investigating The Metabolic Progression of Glioblastoma With Hyperpolarized Magnetic Resonance
… was to determine whether metabolic imaging with hyperpolarized magnetic resonance spectroscopy (MRS) could detect changes in tumor progression more rapidly than conventional anatomic magnetic resonance imaging (MRI) in patient-derived GBM murine models. To comprehensively capture the dynamic …
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Development of pulse sequences for hyperpolarized 13C magnetic resonance spectroscopic imaging of tumour metabolism
Metabolic imaging with hyperpolarized 13C-labeled cell substrates is a promising technique for imaging tissue metabolism in vivo. However, the transient nature of the hyperpolarization - and its depletion following excitation - limits the imaging time and the number of excitation pulses that can be …
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Improved Visualization and Quantification for Hyperpolarized 129Xe MRI
… </p><p> In recent years, the introduction of hyperpolarized (HP) 129Xe magnetic resonance imaging (MRI) into clinical research has provided a robust and non-invasive 3D imaging technique, capable of both high-resolution imaging of pulmonary ventilation and gas exchange. Notably, gas exchange …
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Novel approaches to MRI of glioma
… homeostasis. Non-invasive detection of 23Na with MRI has the potential to quantify sodium concentration and therefore could be an imaging probe of cell morphology and membrane function within the tumour microenvironment, as well as a method of probing tissue heterogeneity. During my PhD, a novel …
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Hyperpolarized Carbon-13 Magnetic Resonance Measurements of Tissue Perfusion and Metabolism
<p>Hyperpolarized Magnetic Resonance Imaging (HP MRI) is an emerging modality that enables non-invasive interrogation of cells and tissues with unprecedented biochemical detail. This technology provides rapid imaging measurements of the activity of a small quantity of molecules with a strongly …
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Hyperpolarized 3He-diffusion MRI in evaluation of lung structure in emphysema. Validation and development of the method
… early stages before symptoms present themselves. MRI with hyperpolarized 3He using diffusion weighted sequences has the potential to detect and quantify parenchyma destruction in emphysema, the main manifestation of COPD. Study I investigated the short-term reproducibility of the method and the …
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Translational Imaging of Pulmonary Gas-Exchange Using Hyperpolarized 129Xe Magnetic Resonance Imaging
… by taking advantage of the unique properties of hyperpolarized (HP) <super>129</super>Xe in conjunction with magnetic resonance imaging (MRI), to probe the fundamental function of the lung - gas-exchange. </p><p>While a bulk of the inhaled HP <super>129</super>Xe stays in the alveolar spaces, its …
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Dynamic 129Xe Magnetic Resonance Spectroscopy: Development and Application in Diverse Cardiopulmonary Diseases
… patients to receive optimal treatment. </p><p>Hyperpolarized 129Xe MR imaging (MRI) and spectroscopy (MRS) have emerged as a powerful tool for assessing the pulmonary environment due xenon exhibiting distinct chemical shifts as it diffuses from the airspaces, through the alveolar membrane, and …