Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 63 for “"Hyperpolarized"”.
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Hyperpolarized xenon-129 production and applications
<p>Hyperpolarized 3He and 129Xe were initially developed and used in the nuclear physics community. Lately they are primarily used in Medical Resonance Imaging (MRI). Although first MRI polarized gas images were acquired using 129Xe, the research community has focused mostly on 3He, due to the …
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Improved Visualization and Quantification for Hyperpolarized 129Xe MRI
… </p><p> In recent years, the introduction of hyperpolarized (HP) 129Xe magnetic resonance imaging (MRI) into clinical research has provided a robust and non-invasive 3D imaging technique, capable of both high-resolution imaging of pulmonary ventilation and gas exchange. Notably, gas exchange …
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Studies of Lung Micromechanics via Hyperpolarized 3He Diffusion NMR
While high quality MR Images of lungs are difficult to obtain with conventional proton MRI due to the organ's low tissue density, the advent of techniques in noble gas polarization have enabled MR investigations of the lung's more abundant air space rather than its tissue. In addition to …
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Quantification of Pulmonary Ventilation using Hyperpolarized 3He Magnetic Resonance Imaging
… current techniques for evaluating lung function. Hyperpolarized 3He magnetic resonance imaging (MRI) is a relatively new technique, and quantitative measurements derived from these images, specifically the ventilation defect volume (VDV) and ventilation defect percent (VDP) have the potential to …
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Investigating The Metabolic Progression of Glioblastoma With Hyperpolarized Magnetic Resonance
… was to determine whether metabolic imaging with hyperpolarized magnetic resonance spectroscopy (MRS) could detect changes in tumor progression more rapidly than conventional anatomic magnetic resonance imaging (MRI) in patient-derived GBM murine models. To comprehensively capture the dynamic …
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Hyperpolarized Xenon-129 Magnetic Resonance Imaging of Functional Lung Microstructure
<p>Hyperpolarized 129Xe (HXe) is a non-invasive contrast agent for lung magnetic resonance imaging (MRI), which upon inhalation follows the functional pathway of oxygen in the lung by dissolving into lung tissue structures and entering the blood stream. HXe MRI therefore provides unique …
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Cryptophane Derivatives as Gas Sensors and Hyperpolarized Xenon-129 Biosensors
… CRYPTOPHANE DERIVATIVES AS GAS SENSORS AND HYPERPOLARIZED XENON-129 BIOSENSORS Najat S. Khan Professor Ivan J. Dmochowski This thesis describes the progress in the development of cryptophanes for three different applications: encapsulation of noble gases, 129Xe NMR biosensing for cancer …
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Leveraging Bioorthogonal Chemistry for Hyperpolarized Magnetic Resonance and Metal Uncaging
… of imaging and metal uncaging. We first consider hyperpolarized magnetic resonance, a powerful tool in clinical and biochemical imaging that suffers from short signal lifetimes, which are typically less than a minute for many common molecular probes. Bioorthogonal handles such as azides and …
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Technical Development of Hyperpolarized [1-13C]Pyruvate Imaging for Clinical Translation
Magnetic resonance imaging with hyperpolarized [1-13C]pyruvate is an emerging tool for assessing in vivo metabolism noninvasively. Over the past few years since the first clinical study with prostate cancer patients, translational studies using this imaging technique have been focused on …
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Hyperpolarized Carbon-13 Magnetic Resonance Measurements of Tissue Perfusion and Metabolism
<p>Hyperpolarized Magnetic Resonance Imaging (HP MRI) is an emerging modality that enables non-invasive interrogation of cells and tissues with unprecedented biochemical detail. This technology provides rapid imaging measurements of the activity of a small quantity of molecules with a strongly …
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Hardware for performing hyperpolarized helium imaging on a clinical MR imager
Thesis (M.Eng.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2002.
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Sensitivity and Specificity of Detecting Premalignant Pancreatic Lesions by Hyperpolarized Magnetic Resonance
… a non-invasive imaging modality called hyperpolarized magnetic resonance (HP MR) metabolic imaging. HP MR increases the signal of conventional MRI by over 10,000-fold and can interrogate the dynamic metabolic flux (lactate-to-pyruvate ratio) <em>in vivo</em> in real time. Concurrently, …
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Translational Imaging of Pulmonary Gas-Exchange Using Hyperpolarized 129Xe Magnetic Resonance Imaging
… by taking advantage of the unique properties of hyperpolarized (HP) <super>129</super>Xe in conjunction with magnetic resonance imaging (MRI), to probe the fundamental function of the lung - gas-exchange. </p><p>While a bulk of the inhaled HP <super>129</super>Xe stays in the alveolar spaces, its …
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Hyperpolarized noble gas magnetic resonance imaging of human lungs in 150G magnetic field
Thesis (M.Eng.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2000.
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Development of Nitrogen-15- and Carbon-13-Labeled Biochemical Probes for Hyperpolarized Metabolic Imaging
Pages 44-75 are misnumbered as pages 43-74, pages 76-103 are misnumbered as pages 73-100, pages 104-129 are misnumbered as pages 100-125, and pages 130-134 are misnumbered as pages 125-129.
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An Automated Syringe Pump System For Improving The Reproducibility of Dynamic Hyperpolarized Mri Phantoms
… FOR IMPROVING THE REPRODUCIBILITY OF DYNAMIC HYPERPOLARIZED MRI PHANTOMS</p> <p>Harlee Grace Harrison, B.S.</p> <p>Advisory Professor: James Bankson, Ph.D.</p> <p>Magnetic Resonance Imaging (MRI) is a powerful tool in the diagnosis of cancer due to its ability to provide good soft tissue …
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Development of pulse sequences for hyperpolarized 13C magnetic resonance spectroscopic imaging of tumour metabolism
Metabolic imaging with hyperpolarized 13C-labeled cell substrates is a promising technique for imaging tissue metabolism in vivo. However, the transient nature of the hyperpolarization - and its depletion following excitation - limits the imaging time and the number of excitation pulses that can be …
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Novel Simulation to Avoid Bias In Measurement of Hyperpolarized Pyruvate: Demonstrated In Phantom and In Vivo
… nuclear polarization creates a transient hyperpolarized nuclear state that can dramatically increase the signal detected by magnetic resonance imaging. This signal increase allows real-time spectroscopic imaging of specific metabolites <em>in vivo </em>by magnetic resonance. Real-time …
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Hyperpolarized Nuclei for NMR Imaging and Spectroscopy – Methodology and model studies of lung and vascular function
… orders of magnitude. The increased signal from hyperpolarized substances enables investigation of non-proton nuclei, and thus makes novel kinds of examinations possible, e.g., imaging of the lungs and respiratory airways after inhalation of hyperpolarized gas. In this work, applications related …
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