Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"Hyperpolarised MRI"”.
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Clinical and biological validation of hyperpolarised MRI of prostate cancer
… of pre-biopsy magnetic resonance imaging (MRI) as the first-line investigation in patients with suspected PCa has created a paradigm shift in PCa diagnostic pathway. With its negative predictive value above 90%, pre-biopsy MRI halves the number of unnecessary biopsies and significantly …
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Using SABRE in NMR and MRI
… technique in both NMR spectroscopy and MRI. Hyperpolarisation is a method of generating enhanced magnetic resonance signals to improve signal to noise, contrast and resolution within those techniques. The primary aim of this thesis was to develop the SABRE method in the context of …
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Detecting tumour responses to treatment using metabolic imaging with hyperpolarised [1-13C]pyruvate and 2-([18F]fluoro)-2-deoxy-D-glucose
… positron emission tomography ([18F]FDG-PET) and hyperpolarised [1-13C]pyruvate magnetic resonance imaging), for the purpose of detecting early responses to treatment in mouse models of cancer. Two mouse models of lymphoma, subcutaneous EL4 tumours and Eμ-Myc transgenic mice, were treated with …
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Development of imaging techniques to assess tumour cell death
Cell death is an important imaging target for assessing early tumour treatment response and the effectiveness of therapy. Traditionally, anatomical imaging modalities measure changes in tumour size (Response Evaluation Criteria in Solid Tumours (RECIST)). More recently these assessments have also …
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Novel multi-parametric, multi-modality imaging for the assessment of tumour biology in renal cell carcinoma
… investigated morphological and physiological 1H-MRI to detect early response and predict outcome. Multiparametric MRI demonstrated physiological changes after 12 days of anti-vascular therapy, which were compatible with its mechanism of action. The reduction in tumour diffusivity correlated with …
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Development of Optimised Pulse Sequences for Magnetic Resonance Imaging of Tumour Metabolism
Development of efficient pulse sequences for hyperpolarised 13C imaging: Dynamic nuclear spin polarization of 13C-labeled cell substrates has enabled dynamic measurements of tissue metabolism in vivo using 13C MRSI. The principal limitation of the technique is the short lifetime of the …