Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 36 for “"Hyperoxia"”.
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Extracellular Superoxide Dismutase Protects Cardiomyocytes During Hyperoxia
… In the EC-SOD TG mice, 6 hours of exposure to hyperoxia activated the transcription of nuclear genes important for mitochondrial biogenesis---nuclear respiratory factors (NRF-1 and NRF-2) and their co-regulator PGC-1α---leading to expression of mitochondrial transcription factor A (Tfam), which …
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Seizures Cause Long-Lasting Analgesia and Short-Lasting Hyperoxia
… A single seizure also led to an acute period of hyperoxia in the locus coeruleus lasting approximately 15-20 minutes after the seizure. Administration of AM251 decreased this hyperoxia in females and increased it in males. Significance: This study increased our understanding of postictal …
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Energy failure following traumatic brain injury: Potential mechanisms and impact of normobaric hyperoxia
… as imaging biomarkers to investigate normobaric hyperoxia as a therapeutic option following traumatic brain injury (TBI). Using ([18F] FMISO PET evidence of tissue hypoxia consistent with microvascular ischaemia was found across the injured brain. The impact of normobaric hyperoxia (NBH) was …
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Global transcriptional analysis of an Escherichia coli recombinant protein process during hypoxia and hyperoxia
(cont.) The effects of recombinant protein production were observed through expression analysis of induced, uninduced, and Empty-Vector cultures. As expected, recombinant α₁AT production led to increased expression of heat-shock genes, including proteases and chaperones that are known to be …
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Effects of Hyperoxia on Thermal Tolerance and Indicators of Hypoxic Stress in Antarctic Fishes That Differ in Expression of Oxygen-Binding Proteins
… under normoxia and environmental hyperoxia. I have determined that a 3- to 4-fold elevation in environmental oxygen does not extend CT<sub>MAX</sub> in either species despite a 1.7-fold reduction in plasma lactate accumulation and a 2- to 3-fold increase in oxygen utilization as …
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AMBIENT OXYGEN AVAILABILITY MODULATES EXPRESSION OF VASCULAR ANGIOGENIC FACTORS AND CAPILLARY REMODELING (ANGIOPLASTICITY) IN THE MOUSE BRAIN
… C57BL/6J mice exposed to normoxia, hypoxia or hyperoxia, we studied the systemic physiological and brain microvascular adaptive changes in response to fluctuations in atmospheric oxygen level. In the first part of this project, we determined the relative time course of capillary angiogenesis …
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Role of selenium in neonatal lung development
… development of neonatal lungs under normoxia and hyperoxia. Lung development was assessed by measuring certain parameters of functional and structural development, including pulmonary phospholipids and histomorphometry. Lung lesions due to hyperoxia were assessed by histopathological examination …
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Investigating Notch/Dll4 signalling in retinal microvascular cells in health and disease
… EC-P interaction. <br/><br/>In part 3 using hyperoxia to model the early pathology of ROP we investigated the effect of hyperoxia on EC and on Notch signalling in particular. We demonstrated hyperoxia to have detrimental effects upon endothelial functions such as decreased proliferation with …
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Ceramides as Therapeutic Targets in Bronchopulmonary Dysplasia
… link between the injurious stimulus (e.g., hyperoxia) and disrupted lung development has been less clear. Recent works suggest the up regulation of ceramides in the injured lung as a potentially key factor. Ceramides regulate tissue growth pathways, by increasing autophagy and apoptosis. …
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Hypoxia and thermal tolerance in New Zealand triplefin fishes
… to variability in O₂ availability (hypoxia and hyperoxia) and increased temperature (acute and chronic exposure). Decreased O₂ availability (hypoxia) is common in rock pools and challenges the aerobic metabolism of fishes living in these habitats. In Chapter 2, the critical O₂ tension (Pcrit) - …
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The Effects of Altered Partial Pressures of Gas on Cognitive and Neural Function
… <br/>oxygen levels, whether through Hypoxia, Hyperoxia, or Hyperbaric Oxygen Therapy (HBOT), <br/>shape cognition and brain activity remain incomplete. This thesis adopts a novel, multi-modal <br/>framework that integrates normobaric gas manipulations, cognitive testing, Transcranial …
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DYNAMIC BEHAVIOR AND LINEAGE PLASTICITY OF THE PULMONARY VENOUS ENDOTHELIUM
… development, adult viral injury, and adult hyperoxia injury. Remarkably, we observed that venous endothelial cells proliferate into the adjacent capillary bed upon influenza injury and hyperoxia injury, but not during normal postnatal development. Imaging analysis demonstrated that venous …
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Effect of oxidative stress on <i>Escherichia coli sodA-sodB-</i>: protection by the mimic of superoxide dismutase, Mn(III)-salophen
… imposed by exposure of the cells to paraquat or hyperoxia. Cells were grown in LB medium overnight, washed and resuspended in the indicated glucose/salts medium supplemented with casamino acids. The effect of Mn(III)-salophen in the oxidative stress model <i>in vivo</i> was measured in terms of …
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Role of Soluble [alpha]-Klotho in the Alleviation of Acute Lung Injury
… experimental injury models, cigarette smoke or hyperoxia. Mouse bronchoalveolar lavage fluid (BALF) was assayed for oxidative damage to compare age, genotype, and exposure; fixed lungs were sectioned, stained, and the morphology examined. Next, exogenous Klotho was incorporated into …
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Oxygen resuscitation does not ameliorate neonatal hypoxia/ischemia-induced edema
… fluid accumulation are poorly understood. Hyperoxia treatment after HI (HHI) is the recommended clinical therapy for newborn resuscitation. Our objective was to evaluate edema development after HI and whether HHI treatment affected HI-induced edema. We induced HI by a permanent ligation of …
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Unstable Ventilatory Control During Sleep After High Spinal Cord Injury: The Contribution Of Chemosensitivity And Hypoventilation
… of the peripheral chemoreceptors to brief hyperoxia (60 seconds of >60% FiO2) and hypercapnia (a single breath of elevated CO2). I studied subjects with chronic cervical and high thoracic SCI and matched able-bodied subjects. For the first aim subjects underwent polysomnography, which …
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