Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 51 for “"Hypermethylation"”.
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Aberrant epigenetics in the molecular pathogenesis of human acute myeloid leukemia
Promoter hypermethylation mediated gene silencing is a frequent epigenetic finding in many cancers that affects genes known to have important roles in several aspects of cell biology. Hematological malignancies have been reported to harbor multiple genes aberrantly silenced by promoter …
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DNA synthesis and methylation in normal and transformed cells
… cell line (CT-1). HU was shown to enhance hypermethylation of pre-existing DNA strands in the normal cells, while ara-C and aphidicolin caused hypermethylation of newly synthesized DNA strands. The effects of various concentrations of a known inducer of gene expression, sodium butyrate, …
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Studies on the mammalian piRNA pathway in cancer cells
… harbour many epigenetic defects, including the hypermethylation of CpG islands (CGI). The mechanism underlying aberrant CGI methylation, which often silences genes whose inactivation favours tumour growth, remains unknown. CGI hypermethylation occurs against a background of global …
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Investigating Clozapine-Induced Myocarditis in Stem Cell-Derived Cardiomyocytes from Treatment-Resistant Schizophrenia Patients: A Pharmacoepigenomic Approach
… myocarditis risk. In cases, there was a notable hypermethylation at the promoter regions of genes such as GSTM1 and ZNF559, which was correlated with decreased gene expression. Conversely, hypermethylation in the gene bodies of AKAP7 and HLA-DRB1 was associated with increased expression. In …
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Epigenetic Modulation In Braf Mutated Metastatic Colorectal Cancer
… BRAF V600E mutations are associated with global hypermethylation, which may turn off tumor suppressor gene expression. We studied demethylation in BRAF V600E mCRC to restore sensitivity to BRAF inhibitors.</p> <p><strong>Methods:</strong> Tumor databanks were investigated for genes differentially …
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Mismatch Repair Deficient Tumors Lacking Known Sporadic Causes: Are They All Due to Lynch Syndrome?
… cancers in the absence of <em>MLH1 </em>promoter hypermethylation and <em>BRAF</em> mutations are suggestive of Lynch syndrome (LS). Positive germline genetic test results confirm LS. It is unclear if individuals with MMRD tumors but no identified germline mutation or sporadic cause …
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The development of a blood-based test of DNA methylation for the earlier detection of high-grade serous tubo-ovarian cancer
… seven showed statistically significant hypermethylation (p<0.0001) from NFT-STIC-HGSC FFPE tissue samples. Diagnostic accuracy was improved compared to CA125 in two markers. Statistically significant hypermethylation (p=0.009) was detected using MSRE qPCR in plasma cell free DNA (cfDNA) …
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Regulation and activity of the 5-methylcytosine DNA glycosylase ROS1 contributes to DNA methylation patterning across development
… patterning. We show that ROS1 prevents hypermethylation of paternally-inherited alleles in the endosperm at regions that lack maternal or paternal-allele methylation in wild-type. Thus, ROS1 promotes epigenetic symmetry between genomes in the endosperm by preventing paternal genome …
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ZNF300 may influence the metastatic properties in pancreatic ductal adenocarcinoma
… members, identified genes exhibiting promoter hypermethylation in a high metastatic cell line, L3.6pl, compared to the lowly metastatic isogenic variant cell line, FG. One of those genes, ZNF300, was chosen as a candidate gene for many reasons. First, analysis of percent methylation within the …
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Sex-dependent and Sex-independent Gene Regulation after Peripheral Nerve Injury
… I discovered that PNI resulted in genome-wide hypermethylation throughout the spinal cord and blood of both sexes. I identified robust sex differences in the global methylation of PAG. I found global hypermethylation in male PAG and global hypomethylation in female PAG after PNI. Moreover, I …
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Chronic oxidative stress and susceptibility to renal carcinogenesis
… potential further suggested possible role of DNA hypermethylation in chronic oxidative stress induced changes. Increased growth and tumorigenic potential of Caki-1 cells with up-regulation of metastasis and EMT related genes, further confirm role of chronic oxidative stress in progression of …
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A candidate gene based investigation of aberrant DNA methylation in the pathogenesis of primary cutaneous T-cell lymphoma
… under-expression, attributed to the positional hypermethylation of five CpG din-ucleotides in the Fas CpG island. PLS3, an actin-binding protein not normally expressed in any haematopoietic cell, was aberrantly expressed in malignant cells from 21/35 SS patients and 3/8 MF patients with …
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Micrornas in Breast Cancer Metastasis: Molecular Regulation of Endothelial Recruitment by Cancer Cells & Regulation of Metastasis Suppressor Micrornas
… both genetic deletion and epigenetic promoter hypermethylation in metastatic derivatives obtained from independent patients' tumours. Additionally, matched primary tumour-metastases pairs revealed the silencing of miR-335 expression to occur at least partially through genetic deletion. Genetic …
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The Role of TET Proteins in the Epigenetic Regulation of Neural Gene Expression and Behavior
… studies have found associations between OXTR DNA hypermethylation and a wide spectrum of behavioral traits and neuropsychiatric disorders including autism spectrum disorders. Here we report the first evidence for an epigenetic mechanism of Oxtr transcription as expression of Oxtr is reduced in the …
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STUDIO DELL¿ASSOCIAZIONE TRA INQUINAMENTO ATMOSFERICO E DISTURBO DEPRESSIVO MAGGIORE: RUOLO DI MARCATORI BIOLOGICI ED EPIGENETICI
… was associated with hypomethylation of CRY2 and hypermethylation of OX1R, CRY1, and ARNTL at different lags of exposure within the two weeks preceding recruitment. Long-term exposure to PM10 (average of the three- and six-months preceding recruitment) was positively associated with CRY1 and …
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An investigation of genome-wide promoter region cytosine-phosphate-guanine (CpG) Island methylation profiles in patients with chronic hepatitis B virus infection
… with no liver disease. The study identified hypermethylation in promoter regions, transcription start sites, gene exons and introns. Only sites in the promoter region and within 100bp upstream of a transcription start site were analysed for this thesis presentation. Using an extended cohort …
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ROLE OF A SPECIFIC NANOG SUPER-ENHANCER ERNA IN EPIGENETIC REMODELING AND ENHANCER-PROMOTER INTERACTION
… the three layers of epigenetic regulation: the hypermethylation of the Nanog promoter and the SE region; the chromatin switch between activation and repression markers; the disruption of the SE-promoter loop responsible of the Nanog gene activation in stemness conditions. Thus, results suggested …
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Identification and characterization of factors involved in DNA demethylation and anti-silencing in Arabidopsis
… the expression of transgenes by preventing DNA hypermethylation at the transgene promoter. Analysis of the methylome of<em>mbd7</em> mutant plants revealed that MBD7 prevents DNA hypermethylation at thousands of genomic loci. MBD7 have been characterized previously as methyl-CpG-binding proteins …
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Multigenerational Neurobehavioural and Reproductive Toxicity of Arsenic in Zebrafish (Danio rerio)
… of drd1, mao, and bdnf in the brain. Promoter hypermethylation of these genes across F0 to F2 generations provided mechanistic evidence for epigenetic inheritance of arsenic-induced neurotoxicity. In Chapter 4, the sex-specific reproductive and developmental toxicity of chronic dietary arsenic …
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