Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"Hyperinsulinism"”.
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Thermodynamics of Ligand Binding to Glutamate Dehydrogenase
… in disease has been exhibited in congenital hyperinsulinism, specifically, hyperinsulinism/hyperammonemia syndrome (HHS). GDH catalyzes the reversible deamination of glutamate to 2-oxoglutarate. Mutations in GDH can lead to GDH over activity, causing increased ATP production via the Krebs …
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Post-alcoholic hypoglycaemia: a clinical and pathological study
… of a "flat" glucose tolerance curve organic hyperinsulinism was suspected. In one case total pancreatectomy was performed but thorough macroscopical and histological investigation failed to reveal a tumour or hyperplasia, and the patient subsequently suffered from diabetes. In August 1958, I …
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The effects of insulin and the insulin-like growth factors (IGF-I and IGF-II) on the proliferation and differentiation of cells isolated from placentae of non-diabetic and diabetic subjects
Maternai peripheral hyperinsulinemia and fetal hyperinsulinism that occurs as a conséquence of the treatment of diabetic pregnancy hâve been associated with both gross and microscopic, cellular changes. Thèse include an apparent hyperplacentation and fetal macrosomia and trophoblastic …
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The Effect of Slowly Digesting Carbohydrates on Abnormal Glucose Tolerance Curves
… diabetes, early mild diabetes, and functional hyperinsulinism. Each group was then averaged, and these averages were graphed for drawing conclusions as to the effects of the test diets.</p> <p><strong>Conclusions </strong></p> <p>1. The rapid or slow availability of the carbohydrate in a …
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Interrogation of the human glutamate dehydrogenase antenna to elucidate its role in allosteric regulation and disease
… importance of this regulation is made evident by hyperinsulinism/hyperammonemia syndrome (HI/HA), where mutations cause GDH hyperactivity. Since only allosterically regulated forms of the enzyme contain an approximately 50-residue antenna domain, it suggests that the antenna is critical for …
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Membrane trafficking of ATP-sensitive potassium channels
… by mutations of Kir6.2 known to cause congenital hyperinsulinism. In summary, it has been demonstrated that both regulated expression and trafficking are likely to be involved in determining the cell surface density of pancreatic KATP channels.
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Trafficking motifs in potassium channels
… which reduce channel activity, cause congenital hyperinsulinism (CHI) characterized by insulin hyper-secretion and hypoglycemia. The hERG (human ether-a-go-go related gene) potassium channels,encoded by the KCNH2 gene, contribute to the rapidly activating delayed rectifier K+ current (IKr), which …
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Ätiologie des funktionellen Hyperandrogenismus : endokrine Prädiktion von Genalterationen im CYP11a, CYP17, CYP21B,INS VNTR und LHß bei Hyperandrogenämie, Hyperinsulinämie oder Adipositas in prämenopausalen Patientinnen
Untersuchung spezifischer das Polycystische Ovar Sydrom betreffender Kandidatengene
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L'IPERINSULINISMO CONGENITO DELL'INFANZIA E IL REGISTRO ITALIANO (RICI)
Con il termine di Iperinsulinismo Congenito dell'Infanzia (CHI) ci si riferisce ad un gruppo eterogeneo di malattie, differenti tra loro dal punto di vista clinico, genetico e anatomopatologico. Nonostante i progressi nella comprensione dei meccanismi molecolari alla base di questa patologia e …
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The Effects of Macronutrient and Micronutrient Diet Manipulation on Human Insulin Sensitivity
… now clear that insulin resistance (and resultant hyperinsulinism) is implicit with the pathogenesis of a wide range of other diseases, including cancers, and neurodegenerative and infectious diseases. Dietary manipulation as part of lifestyle modification is recognised as a fundamental way to …
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Gene misexpression in humans
… congenital limb malformations, congenital hyperinsulinism and monogenic severe childhood obesity. These studies have identified gain-of-function genetic variants that lead to gene misexpression via specific mechanisms. In chapter 1, I review these mechanisms and conclude that despite its …