Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"Hyperinflammation"”.
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Antifungal Immune Responses and Inflammation in the Cystic Fibrosis Airways
… the airways of people with CF and contributes to hyperinflammation and lung function decline. The studies presented in this thesis aimed to obtain an insight into the airway mycobiome of people with CF, as well as getting a broader understanding of the host-fungal interactions. This was done by …
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Antifungal Immune Responses and Inflammation in the Cystic Fibrosis Airways
… the airways of people with CF and contributes to hyperinflammation and lung function decline. The studies presented in this thesis aimed to obtain an insight into the airway mycobiome of people with CF, as well as getting a broader understanding of the host-fungal interactions. This was done by …
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Human coronavirus NL63 envelope protein-protein interactions: role in pathogenesis
… proteins, facilitating immune dysregulation and hyperinflammation. Early work on SARS-CoV-1 revealed that the PBM of its E protein serves as a pathogenic determinant, which was later supported by SARS-CoV-2 studies that demonstrated similar immunopathological outcomes. This raised a central …
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Elucidating the Role of RanBP2/Nup358 in the Regulation of Cytokines mRNAs
… into how mutations in RanBP2 contribute to hyperinflammation in ANE1.
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Control of Shigella sonnei and adhesive invasive Escherichia coli infections with a natural product which inhibits the bacterial oxidoreductase DsbA
… coli (AIEC) cause infections characteristic of hyperinflammation. These infections require antimicrobial therapy. However, due to the widespread emergence of multiple drug-resistant strains, alternative strategies must be sought to combating infectious diseases. It has been shown that natural …
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Development of a novel infection model to test CSF1-Fc as a potential therapeutic for early onset sepsis
… response to infection, involving stages of hyperinflammation that mediate organ damage and dysfunction. Early onset sepsis (EOS) is defined as onset within the first 72 hours after birth. It is caused by ingestion or inhalation of infected fluids either in utero or intrapartum. The only …
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Engineering soluble, high affinity T cell receptor domains for detection of staphylococcal and streptococcal exotoxins
… fraction of an individual’s T cells, leading to hyperinflammation and in some cases, organ failure and death. The molecular mechanism behind hyperinflammation has been attributed to the binding of superantigen (SAg) to both a T cell receptor (TCR) on a T cell, and a class II product of the major …
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The role of cell type-specific tumour necrosis factor in protective immunity against neurotuberculosis
… factor has been implicated in persisting hyperinflammation, however, deficiency of tumour necrosis factor lead to uncontrolled bacterial growth; both phenomena causing necrotic lysis. Thus, a need exists to investigate the contribution of tumour necrosis factor by specific cell types in …
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Advancing sepsis treatment: synthesis and evaluation of multi-target drugs with antimicrobial, antioxidant and anticoagulant properties.
… It is triggered by infection, leading to hyperinflammation, oxidative stress (OS), excessive blood coagulation and, in severe cases, death. Globally, sepsis accounts for approximately 11 million deaths each year, with around 245,000 cases reported annually in the UK. The intricate clinical …
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Brain Endothelial Cells Orchestrate an Anti-Encephalitic State in the Central Nervous System in Response to Peripheral Viral Infection
… in the CNS. Neurovirulent WNV infection elicits hyperinflammation in the CNS, leading to deleterious clinical outcomes including weakness, memory loss, paralysis, and death. Fortunately, only 1% of individuals infected with WNV progress to the encephalitic stage, although the reasons for this …
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Activation of the TLR4 Signalling Complex by the Ebola Virus Glycoprotein
… signalling, has been identified as the source of hyperinflammation during Ebola virus infection. The molecular basis of TLR4 agonism by GP1,2 and also other viral proteins is unknown to date, and this body of work goes some way to explore this interaction. This thesis explores the Ebola virus …
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Investigating clonal hematopoiesis in rhesus macaque and human
… Furthermore, though CH has been shown to lead to hyperinflammation in murine models, its clinical implication in inflammatory disease such as COVID-19 has yet to be understood. Objectives 1. To examine the CH mutation landscape in blood cells from aged rhesus macaques (RMs) and to develop an …
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Phenotypic characterisation of wild type and mutant strains of adherent invasive Escherichia coli and Shigella, in vitro, ex vivo and in vivo models
… study, may have a role to play in modulating the hyperinflammation feature of Crohn's disease and shigellosis.
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Investigating the molecular pathogenesis of tuberculosis-associated immune reconstitution inflammatory syndrome
… therapy (ART). TB-IRIS is characterized by hyperinflammation and tissue damage. Pulmonary and lymph node involvement are the most common clinical manifestations. The incidence of TB-IRIS can reach up to 54% in settings where both HIV and TB are endemic, such as the sub-Saharan-Africa region …