Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"Hypericin"”.
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Inhibition des Proteasoms : ein molekularer Wirkmechanismus von Hypericin
… Arbeit wurden molekulare Wirkmechanismen von Hypericin, <br>eines Inhaltsstoffes des Johanniskrautes, untersucht. Johanniskraut-Extrakte werden weitverbreitet als antidepressiv wirkende Substanz eingesetzt. Darüber hinaus werden eine Apoptose-induzierende Wirkung, die Sensibilisierung von …
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Effekte von Hypericin auf humane renale Karzinomzellen in vitro
… Einer seiner Inhaltsstoffe, das so genannte Hypericin, ist namensgebend für diese Pflanzengattung und wird in speziellen Drüsen auf Blütenblättern und Blättern produziert. Es dient der Pflanze als Fraßschutz, denn nach Aufnahme führt es in Organismen bei gleichzeitiger Lichtexposition zu …
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Primary photoprocesses of light-activated antiviral and antitumor agents, hypericin and hypocrellin
… fluorescence upconversion and applying them to hypericin, hypocrellin A and B, and their methylated analogs that are unable to execute proton transfer, it was demonstrated that intramolecular excited-state hydrogen atom transfer is a dominant primary nonradiative process;For hypocrellin A in …
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Investigating the by-stander effect of Hypericin induced photodynamic therapy on human skin cells
… skin cancers. Our group investigates hypericin-induced PDT (HYP-PDT) for the treatment of both non-melanoma and melanoma skin cancers. However, a prerequisite for effective cancer treatments is efficient and selective targeting of the tumoral cells with minimal collateral damage to the …
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Evaluating the Fungistatic and Fungicidal Activities of Bianthrones as Synthetic Intermediates to Novel Hypericin Analogues.
… of anthraquinone, anthrone, bianthrone and hypericin type derivatives and the effect they have on the growth of the yeast species Schizosaccharomyces pombe, Lipomyces starkeyi andSaccharomyces cerevisiae. It is hoped that a new antifungal agent could be identified to combat the threat of …
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St John's Wort photomedicine for Melonoma
… including apoptosis, necrosis and autophagy. Hypericin, an extract from St John's Wort, is a promising photosensitizer in the context of clinical photodynamic therapy due to its excellent photosensitizing properties and tumoritropic characteristics. However, limited reports on the efficacy of …
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An investigation into the cellular mechanisms underlying photodynamic rejuvenation in human skin
… was to first optimise a protocol using the PS, hypericin, activated with 3 different light sources. Hypericin, an extract from St Johns Wort, is a second generation PS that has many benefits such as low dark cytotoxicity, no carcinogenicity/mutagenicity, high quantum yield and can be activated …
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Antiviral activities of selected Chinese medicinal plants
… of the genus Hypericum (Hypericaceae). Three hypericin derivatives and five related quinones were tested in structure-activity relationship studies. The new derivative 2,5,9,12-tetra-(carboxyethylthiomethyl) hypericin showed potent photosensitive virucidal activity against membrane-enveloped …
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Phenanthroperylenchinon-Pigmente in fossilen Crinoiden : Charakterisierung, Vorkommen und Diagenese
… konnten die Pigmente schließlich als Hypericin (C30H16O8), Desmethylhypericin (C29H14O8) und Fringelit F (C28H12O8) identifiziert werden. Ein in geringen Mengen vorkommender Kohlenwasserstoff konnte als 1,2,3,4,5,6-Hexahydrophenanthro[1,10,9,8-opqra]perylen charakterisiert werden. Die …
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Neurophysiologische Charakterisierung der wasserlöslichen Fraktion eines Johanniskrautextraktes und dessen Einfluß auf die Langzeitpotenzierung
… zusammenzusetzen. Zwei der Wirkstoffe, Hypericin und Hyperforin, hielt man bislang für die wesentlichen neuroaktiven Bestandteile von Johanniskrautextrakten. <br>Eine wasserlösliche Fraktion von Hypericum perforatum (HYPWS, hypericum perforatum water soluble), die weder Hypericin noch …
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An investigation into the synergistic action of chemotherapy and photodynamic therapy in resistant skin cancers
… then to investigate the possible synergism of hypericin activated-photodynamic therapy in reducing (HYP-PDT) melanoma cell viability, when combined with chemotherapy. In addition we wanted to assess the morphology and the clonogenic capacity of the melanoma cells, after the different treatments …
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The premenstrual syndrome: characterisation, diagnosis and treatment
… 1983) were administered 900mg SJW/day (0.18% hypericin; 3.38% hyperforin) for two menstrual cycles (n=34). SJW was found to benefit physical and behavioural PMS symptoms, but did not significantly improve mood or pain symptoms. A comparison of various commonly used analytical strategies …
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Comparison of the therapeutic efficacy of SNAP-tag fusion protein and the synergistic actions of chemotherapy and photodynamic therapy in killing resistant melanoma
… actions of chemotherapy (Dacarbazine:DTIC) and hypericin-activated photodynamic therapy (HYP-PDT) in reducing chemoresistance in DTIC resistant (UCT Mel1DTICR2) and non-resistant melanoma cells (UCT Mel-1). To achieve these goals, the therapeutic efficacy of conventional therapies (DTIC, HYP-PDT …