Global ETD Search
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Showing 1 to 11 of 11 for “"Hyperhomocysteinemia"”.
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Hyperhomocysteinemia: inherited causes and effects of treatment
Contains fulltext : mmubn000001_235021652.pdf (Publisher’s version ) (Open Access)
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Genetic Association Study of Osteoporotic Vertebral Compression Fractures in Postmenopausal Women
… known to promote the healing of fractures and hyperhomocysteinemia is associated with the risk of skeletal health problems, such as osteoporosis, low body mineral density, and fracture. 5, 10-Methylenetetrahydrofolate reductase (MTHFR) and thymidylate synthase (TS) are involved in homocysteine …
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Correlation of Homocysteine Concentration with Plasma Fibrinogen and Physical Activity in Males with Coronary Artery Disease
… ratio. These results support the hypothesis that hyperhomocysteinemia is an independent risk factor for CAD. Future studies should consider the favorable effects of beta-blockade, which may be a confounding factor, on Hcy and fibrinogen concentrations. Knowledge of associations may contribute …
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Role of Betaine-Homocysteine S-Methyltransferase in Homocysteine Methylation
… BHMT. To address whether BHMT inhibition caused hyperhomocysteinemia, mice were injected with 1mg of D,L-CBHcy. This reduced BHMT activity (87%) and elevated total plasma Hcy (tHcy, 2.7-fold) for 8 hours. Repeated intraperitoneal injections of D,L-CBHcy (6 doses) additionally reduced the liver …
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Folate Status and Supplementation in the Horse
… a decline in folate status resulting in moderate hyperhomocysteinemia, but not clinical signs of anemia. Peptidoglycan as a source of formylated folate and FA were not effective in improving folate status in horses coadministered PYR and SDZ, two anti-folate drugs commonly administered in equine …
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Smooth Muscle Cell Stress Response: Essential in Atherosclerotic Pathogenesis
… to no cholesterol exposure. Additionally, in a hyperhomocysteinemia and hypercholesterolemia mouse model, we demonstrated the pivotal role of SMC involvement in augmenting atherosclerotic plaque burden through a similar pathway.</p> <p>These findings collectively expand our understanding of the …
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Total Plasma Homocysteine, Vitamins, Abdominal Aortic Aneurysm and Peripheral Vascular Disease
<b>Introduction</b><br/>Hyperhomocysteinemia (>15µmol/L) is a recognised independent risk factor in the genesis of vascular diseases. There are few data on the relationship between homocysteine and abdominal aortic aneurysm (AAA), peripheral vascular disease (PVD), and the effect of vitamin …
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National patterns of breakfast consumption: Nutritional and health implications
… overweight/obese, having abdominal obesity, and hyperhomocysteinemia. Thus, compared to BS and OB consumers, RTEC consumers had better nutrient intakes/adequacy and diet quality, as well as lower adiposity measures and serum/plasma metabolic risk factors.
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The Role of Potassium in Betaine-Homocysteine Methyltransferase
Homocysteine (Hcy) is an intermediate of methionine metabolism and acts as a critical branch point between protein synthesis and numerous regulatory pathways in the cell. Elevated plasma total Hcy (tHcy) is associated with an increased risk for cardiovascular disease, although the mechanism by …
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Mechanisms responsible for homocysteine mediated damage to human endothelial cells : the role of oxidative stress in atherogenesis.
Homocysteine (Hcy) has been identified as a primary risk factor for atherosclerosis as it induces endothelial cell (EC) activation/dysfunction and thus potentially initiating atherosclerotic plaque formation. There is accumulating evidence indicating a key role for oxidative stress in mediating Hcy …
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Implication of homocysteine, resistin and vitamin D in development of type 2 diabetes
… the present of the genetic mutation which led to hyperhomocysteinemia. Objective: The aim of this study was to investigate possible associations between homocysteine, resistin and vitamin D with T2DM in a representative study population from Sudan. In addition, associations between the Methyl …