Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 107 for “"Hyperglycaemia"”.
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Hyperglycaemia, insulin and acute ischaemic stroke
Background: Hyperglycaemia is common in acute stroke and is associated with a poor outcome. Underlying aetiology and mechanism of action is poorly understood. Management remains uncertain. Methods: We undertook a randomised placebo controlled trial to assess the effect of GKI …
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The effects of hyperglycaemia on neuronal mitochondria
Neurons depend on mitochondria more than any other cell type for their growth and survival. Mitochondria are known as the main powerhouse of the cell because of their important metabolic functions. Through the processes of the electron transport chain (ETC) and oxidative phosphorylation, …
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The use of hair detect (and monitor) chronic hyperglycaemia
… This metabolic disorder is characterized by hyperglycaemia, which results in debilitating and life-threatening complications. It is, therefore, vital for diabetics to monitor and control their blood glucose levels in order to keep them below 7mmol/L while fasting and below 9mmol/L after …
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Investigation of hypoxia and hyperglycaemia mediated DNA damage in human endothelial cells.
Chronic complications of diabetes mellitus are a pathological consequence of unregulated levels of blood glucose leading to disorders of the vascular system. When investigating the vascular complications the changes in the endothelium are of particular significance as they are central to vascular …
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Non-invasive detection of hyperglycaemia in type 1 diabetic patients using electrocardiographic signals
Hyperglycaemia is the medical term for a state caused by a high level of blood glucose, resulting from defects in insulin secretion, insulin action, or both. Hyperglycaemia is a common dangerous complication to glycaemic control in Type 1 diabetic patients. The chronic hyperglycaemia of diabetes is …
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Metabolism in Vascular Endothelial Cells: Effects of Hyperglycaemia, Pro-Inflammatory Cytokines and Polyphenols
… to overcome the pro-inflammatory effects of hyperglycaemia and cytokine treatments in HUVECs was investigated using a metabolomics approach with a view to understand the effects at a mechanistic level. As a result, significant changes in HUVEC metabolome in response to treatment with …
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Investigation of the mechanisms underlying the effects of hyperglycaemia on cardiac structural and electrical remodelling
Background: Diabetes mellitus with uncontrolled hyperglycaemia is a major cause of cardiovascular complications and mortality. The developing foetal heart in-utero is particularly susceptible to hyperglycaemia through pathological remodelling, which results in life-long structural abnormalities …
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Influence of HIV, smoking and hyperglycaemia on the reporting of TB symptoms in a TB prevalence survey
Finding and treating cases [of tuberculosis] in the community before they present to health facilities, a strategy known as active-case-finding is gaining momentum as a way to decrease the infectious pool. This can be achieved through door-to-door community surveys using a TB symptom-screening …
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A study on the role of oxidative stress and protein kinase signalling in hyperglycaemia induced cardiac remodelling
… patients with uncontrolled diabetes mellitus and hyperglycaemia are due to cardiovascular diseases. Chronic exposure of the heart to hyperglycaemia leads to a maladaptation called pathological cardiac remodelling and occurs via oxidative stress due to excess production of reactive oxygen species …
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Exploring the experiences of women participating in a lifestyle intervention programme (Iindiago) who had hyperglycaemia first detected in pregnancy
… mortality. One of the major risk factors is Hyperglycaemia First Detected in Pregnancy (HFDP). The prevalence of HFDP is increasing, and it has become one of the common conditions found in women during their pregnancy. It is a significant risk factor for Gestational Diabetes Mellitus (GDM) in …
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Vitamin C status, oxidative stress, hyperglycaemia and endothelial function in critically ill patients with septic shock : an observational study
… reduced levels of plasma vitamin C and stress hyperglycaemia – all factors that may influence endothelial, and therefore, organ function. Vitamin C is an important antioxidant in human plasma; and it has been implicated in maintaining normal endothelial function during oxidative stress. The …
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An exploration of the molecular mechanisms underlying the effects of hyperglycaemia on the autorrhythmicity of cardiac-like stem cells
Introduction Diabetes mellitus with uncontrolled hyperglycaemia is a major risk factor for heart rhythm disturbances. Hyperglycaemia during pregnancy is particularly concerning, as offspring of poorly controlled diabetic mothers are at an increased risk of developing life-long serious …
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Acquired copper imbalance in diabetes-induced cardiac disease: Molecular mechanisms and reversibility
… is a metabolic disorder characterised by chronic hyperglycaemia, which results from disruption of several glucose-control mechanisms. In diabetic patients, it is well established that prolonged hyperglycaemia increases the risk of the cardiovascular complications, which are responsible for up to …
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Type 2 diabetes, cardiovascular risk factors and offspring overweight and obesity 5 to 6 years after hyperglycaemia first detected in pregnancy in Cape Town, South Africa
… health systems. The association between hyperglycaemia first detected in pregnancy (HFDP), which includes both diabetes mellitus in pregnancy (DIP) and gestational diabetes mellitus (GDM), and the later development of T2DM and cardiovascular disease risk in the mothers and possibly …
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An Investigation for Genetic Susceptibility to Type 1 Diabetes Mellitus and its Microvascular Complications
… hyperglycemia and redox imbalance. Uncontrolled hyperglycaemia and genetic factors are implicated in the pathogenesis of diabetic microvascular diseases. Genetic mutation through the genes coding for enzymes involved in glucose metabolism and immuno-regulatory mechanisms may contribute to the …
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In vitro and in vivo effects of sorghum condensed tannins encapsulated in kafirin microparticles on digestive amylases
… amylases and thereby decrease post-prandial hyperglycaemia. Polyphenols like sorghum condensed tannins (SCT) inhibit α-amylase and α-glucosidase enzymes. However, orally administered SCT may have poor inhibitory action against amylases, due to non-specific protein binding. Research is …
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Investigating the integrity of the vasculature and structural relationships of pericytes, astrocytes and the endothelial glycocalyx in an ex vivo hyperglycaemic rat retinal model
… due to diabetic metabolic derangements such as hyperglycaemia. The cellular components of the BRB include endothelial cells, pericytes and the glial cells (mainly astrocytes), which together maintain the integrity and barrier function of the retinal vasculature. However, there is limited data …
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Type II diabetes mellitus and cardiovascular markers in humans: a prospective study in hellenic homogeneous population
… to CVD coexist with diabetic status including hyperglycaemia, dyslipidaemia, inflammation and coagulation, many of which may be closely associated with insulin resistance. In addition, mutations and polymorphisms in a number of genes have also been linked with monogenic and polygenic forms of …
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Vascular breakdown in diabetic retinopathy: Role of connexin43 and possible interventions
… to be because most animal models used are hyperglycaemia-only models that do not take the significance of inflammation in the disease pathogenesis into account. Therefore, the main aim of this thesis was to develop a new DR model that combines both hyperglycaemia and inflammation and use it …
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La glycémie maternelle en grossesse et la leptine dans le sang de cordon : des déterminants de l’adiposité dans l’enfance
… of children are overweight. Exposure to maternal hyperglycaemia complicated or not by gestational diabetes (GDM), maternal adiposity and excessive gestational weight gain (GWG) are factors predisposing children to develop obesity beyond the traditional risk factors such as genetics. This is the …
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