Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 73 for “"Hypercholesterolemia"”.
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Monogenic hypercholesterolemia in South Africans : familial hypercholesterolemia in Indians and familial defective apolipoprotein B-100
… 3500) (FOB), the known causes of monogenic hypercholesterolemia (MH), have similar clinical features. The nature of the mutations responsible for MH in South Africans of Indian origin was previously unknown. Similarly, the mutations in the LDL-receptor gene of a South African Black FH …
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The use of bempedoic acid in treating hypercholesterolemia
… therapy in the treatment of patients with hypercholesterolemia. Though often regarded as relatively low risk and widely effective in treating hypercholesterolemia, statin therapy has a variety of limitations, including statin resistance and statin intolerance. These limitations have led …
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Plant-Based Compound Treatment of Hypercholesterolemia in the Zebrafish
… to test the ability of natural products to treat hypercholesterolemia and its peripheral cardiovascular consequences. In this endeavor, tools are developed and utilized to test the efficacy of the medicinal plant hawthorn (Crataegus laevigata) in treating lipid disorders, with emphasis on those …
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Dietary knowledge, attitudes and behaviours of individuals with diagnosed hypercholesterolemia
… blood cholesterol in patients with diagnosed hypercholesterolemia and to identify predictors of good compliance based on knowledge, attitudinal and socio-demographic characteristics. This report presents data obtained from a self-administered questionnaire sent by mail and from abstraction of …
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Variations in Mevalonate Pathway Flux in Human Cells with Familial Hypercholesterolemia
The general metadata -- e.g., title, author, abstract, subject headings, etc. -- is publicly available, but access to the submitted files is restricted to UT Southwestern campus access and/or authorized UT Southwestern users.
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The molecular and cellular defect underlying autosomal recessive hypercholesterolemia (ARH) in the first kindred identified in South Africa
… underlie the rare autosomal recessive forms of hypercholesterolemia (ARH). One of these proteins is the LDLr adaptor protein know as ARH, which is presumed to facilitate interaction of the cytoplasmic tail of the LDLr with the internal protein matrix required for the receptor internalisation.
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Assessing the effect of statins in lowering the risk of stroke and preventing cerebral ischemia in patients with hypercholesterolemia
… preventing cerebral ischemia in patients with hypercholesterolemia. To achieve this objective, the literature was reviewed, randomized control tests were analyzed, and a systematic review was performed. The risk of developing cerebral ischemia was found to be reduced in hypercholesterolemic …
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The Effect of Hypercholesterolemia on the Membrane Lipids, 3-0-[¹⁴C] Methylglucose Transport, and 2,3-Diphosphoglycerate Levels in Rat Erythrocytes
… dietary cholesterol and cholic acid will produce hypercholesterolemia in rats. For ten months, two groups of rats (six in each group) were fed commercial rat pellets (control group) or rat pellets plus cholesterol (1%) and cholic acid (0.25%) (experimental group). A blood sample from each animal …
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Smoking and High-Fat Diet: Risk Factors Regulating Emphysema Formation
… of emphysema. However, a possible impact of hypercholesterolemia on the destruction of alveoli has not been investigated. The work presented in this thesis identifies the role of hypercholesterolemia in the development of emphysema. It also elucidates new molecular mechanisms leading to the …
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Risk Factors for Vascular Dementia
… (RRR= 1.80, p = .009) and a history of hypercholesterolemia (RRR = 1.85, p = .016) are significant predictors of Alzheimer's disease. A history of tobacco use (RRR = 2.18, p = .01) is a significant predictor of vascular dementia. Stepwise regression analyses indicate that …
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A murine model of developmental programming of atherosclerosis
… indicate a strong association between maternal hypercholesterolemia and increased rates of formation of atherosclerotic lesions in children. It is conceivable that exposure to a high lipid environment during intrauterine development and early postnatal life may emerge as one of the principal …
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Effects of hyperlipidemia on gallbladder motility in dogs
… enrolled. Hyperlipidemia was defined as hypercholesterolemia (>332 mg/dL) and/or hypertriglyceridemia (>143 mg/dL). Dogs with both primary and secondary causes of hyperlipidemia were included. All dogs were fasted for at least 12 hours prior to collection of plasma biochemistry and …
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Characterization of the Non-Proteolytic Mechanism and Cellular Site of Action of PCSK9-Mediated Degradation of the Low-Density Lipoprotein Receptor
… that one therapeutic approach for treating hypercholesterolemia might be to disrupt the PCSK9:LDLR interaction at the cell surface. Recombinant LDLR subfragments were synthesized and added to the medium of cells that overexpressed PCSK9. These sub-fragments restored LDLRs to levels found in …
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Uptake and distribution of 3H-cholesteryl oleyl ether in tissues of cholesterol-fed New Zealand White and Watanabe Heritable Hyperlipidemic rabbits
… the WHHL, suggesting that factors in addition to hypercholesterolemia contribute to atherogenesis at the site of injury. The liver, spleen, and bone marrow were the organs most active in uptake of 3H-COE in the CH-FED, reflecting uptake by the β-VLDL receptor on macrophage-derived cells. In the …
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Local effects of Linoorbitides and enterolactone On intestinal epithelial functions
… like inflammatory bowel disease (IBD) and hypercholesterolemia. We first assessed LOBs and ENL effects on barrier integrity (a pathological hallmark of IBD) in vitro using a monoculture transwell system, and the potential mechanisms involved in maintenance of the barrier. Next, we examined …
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Evaluation of Food Effects on the Oral Pharmacokinetics of Rosuvastatin
… is commonly prescribed for the treatment of hypercholesterolemia and exerts its effect through targeted accumulation in the liver. Current United States and Canadian dosing guidelines indicate no preference for fed or fasted rosuvastatin administration. In this study, we demonstrate for the …
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A comparison of the impact of a heart-healthy diet versus paleolithic nutrition on hyperlipidemia in adults
… selected based on the criteria of a diagnosis of hypercholesterolemia. Subjects were not taking any cholesterol lowering medication and had followed a calorie-controlled diet, based on either the dietary principles of the Academy or the AHA, for at least four months followed by a Paleolithic diet …
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A role of statins against listeria monocytogenes and Mycobacterium tuberculosis infection
… (MDM) isolated from patients with familial hypercholesterolemia (FH) on statin therapy when compared to healthy subjects. Together, our results show that statins induces protection against Mtb in murine macrophages, mice and human mononuclear cells and monocyte†derived macrophages.
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The Effects of Phytosterols on Lipoprotein Particle Size
… popular medication alternative for treatment of hypercholesterolemia and have proven effective. Whether PS decrease risk of cardiovascular disease through other mechanisms, such as lipoprotein particle size and inflammatory markers, remains unclear. PURPOSE: The primary aim of this study was to …
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