Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"Hypercalcemia"”.
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Expression of epithelial and neuroendocrine markers within canine apocrine gland anal sac adenocarcinoma (AGASACA) and the relationship to peripheral hypercalcemia and parathyroid hormone-related protein (PTHrP) expression
… tumor and is commonly associated with peripheral hypercalcemia due to circulating elevated parathyroid hormone-related protein (PTHrP). As the tumor name implies, this neoplasm is attributed to apocrine gland origin, and special staining is not typically performed for additional investigation. Few …
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Modulation Of Renin Secretion By Renal Cortical Interstitial Calcium
… renal interstitium. Thus, we hypothesized that hypercalcemia inhibits PRA via PTH-mediated increases in renal cortical interstitial Ca that act on the CaSR triggering Ca-mediated inhibition of renin secretion. We demonstrated that the CaSR is expressed in JG cells <i>in vivo</i>. Additionally, …
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Predictive model to estimate ionized calcium from routine serum biochemical profiles in dogs
… higher to diagnose hypocalcemia and improved for hypercalcemia. The average difference between the piCal and miCal was 0.002 +/- 0.080 mmol/L. The PI included miCal 94% of the time. For hypercalcemia, piCa was as sensitive (64%) but more specific (99.6%) than tCa and corrected tCa. For …
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Model-Guided Transdermal Formulation of 1α,25-Dihydroxyvitamin D3 for Improved Safety and Efficacy
… is limited due to its propensity to cause hypercalcemia. Our aim is to develop a transdermal formulation of 1,25(OH)2D3 that allows for controlled drug delivery with minimal stimulation of the intestinal calcium ion channel (TRPV6), thereby avoiding the toxic outcome of hypercalcemia. By …
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Treatment response using CT-based rigidity analysis in an animal model of lytic musculoskeletal lesions subjected to systemic therapy
… impaired mobility, bone marrow infiltration and hypercalcemia of malignancy. We induced bone metastases through inoculation of rat femurs with MDA-MB-231 human breast cancer cells in order to compare the effectiveness of various treatment modalities, disease progression and recovery through the …
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The Temporal Nature of Ectopic Activity in Guinea Pig Ventricular Myocardium
… pacing, suggestive of non-ectopic activity. Hypercalcemia and digoxin both produced significantly earlier beats with wider QRS durations, suggestive of ectopic activity. Increasing pacing further shortened RCL during digoxin + hypothermia, a mechanistic identifier of ectopic activity. When …
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Engineering protein self-assembly for biosensing applications
… calcium levels in biological fluids relevant to hypercalcemia. Second, we explored the cooperative self-assembly of hybrid protein cages designed to encapsulate nanoparticles to control their optical properties for enhanced fluorescent biosensing of calcium ions. We employed …
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Synthesis of 20S-Hydroxyvitamin D3 Analogs and Their 1α-Hydroxyl Derivatives as Potent Anti-inflammatory Agents
… (625 µg/day) in human would result in hypercalcemia (toxicity), and 1,25(OH)2D3 has substantial hypercalcemic effects (toxicity) in mice at a dose as low as only 2 µg/kg. Fortunately, during the investigation of novel metabolic pathway of vitamin D3 by cytochrome P450 enzymes, we found …
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Citrate kinetics during regional citrate anticoagulation in extracorporeal organ replacement therapy
… mainly to the induction of hypocalcemia. Hypercalcemia rarely develops, probably due to calcium uptake e.g. by the bones. Hypocalcemia is potentially lethal and is the most important risk with use of citrate anticoagulation. During intermittent high-flux haemodialysis it is primarily due …
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Nuclear-Medical Methods for Diagnosing of Abnormal Parathyroid Glands in Primary and Secondary Hyperparathyroidism // Нуклеарно-медицински методи за диагностика на абнормни паращитовидни жлези при първичен и вторичен хиперпаратиреоидизъм
Първичният хиперпаратироидизъм (ПХПТ) се дължи на свръхпродукция на паратироиден хормон (ПТХ) от една или повече абнормно променени паращитовидни жлези и води до развитие на хиперкалциемия. Доскоро считан за рядко заболяване, в последните години с навлизане в клиничната практика на рутинно …