Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 73 for “"Hyperactivation"”.
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Necrotic cell death: A novel outcome of BHPI-hyperactivation of the anticipatory unfolded protein response
Of the roughly 1 in 8 women that develop breast cancer in their lifetimes, 70% will have estrogen receptor a positive (ERa+) cancer. The standard of care for these cancers is endocrine therapy, including aromatase inhibitors and selective estrogen receptor modulators and degraders (SERMs and …
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Hyperactivation of human sperm by 4-Aminopyridine: key role for mobilisation of stored Ca2+ in the sperm neck
… of Ca2+ may contribute to the regulation of hyperactivation. Ca2+ influx at the plasma membrane is crucial and the sperm specific CatSpers channels are of great importance. In addition, studies on sperm have provided strong evidence that Ca2+ stored in the region of the sperm neck contributes …
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Investigating the clinical value of hyperactivation and intracellular calcium signalling of human spermatozoa and their value in drug screening
Confidential thesis. Abstract and full text under embargo until 12/03/2015.
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Hyperactivated motility in human sperm: regulation, function and significance in IVF
Hyperactivation is a movement pattern elicited by sperm in the female reproductive tract. The transition to hyperactivated movement is characterised by an increase in amplitude and a decrease in symmetry of flagellar bending. The resulting forceful, unequal waveforms produce a swimming style that …
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Reactive Oxygen Species-Induced Necrotic Cell Death
… TGHQ induced ROS generation, DNA strand breaks, hyperactivation of PARP-1, rapid depletion of nicotinamide adenine dinucleotide (NAD), elevations in intracellular Ca2+ concentrations, loss of mitochondrial membrane potential, and subsequent necrotic cell death. Interestingly, PARP-1 …
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Αvβ8 Integrin Interacts With Rhogdi1 to Regulate Rac1 and Cdc42 Activation and Drive Glioblastoma Cell Invasion
… leads to impaired tumor cell invasion due to hyperactivation of the Rho GTPases Rac1 and Cdc42. β8 integrin associates with Rho GDP Dissociation Inhibitor 1 (RhoGDI1), an intracellular signaling effector that sequesters Rho GTPases in their inactive GDP-bound states. Silencing RhoGDI1 …
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A Chemically Induced Colitis Screen Reveals the Necessity for Membrane Traffic in Intestinal Homeostasis
… to endocytic and phagocytic pathways. Hyperactivation of endosomal Toll-like receptors in Smcr8-/- mice causes spontaneous inflammation, and hyperactivation of multiple pathways contributes to DSS susceptibility. TVP23B is a trans-Golgi protein that binds YIPF6. Both TVP23B and YIPF6 …
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Role of Hypoxia-inducible Factor in Kidney Cancer
… of HIF1alpha/HIF2alpha, unchecked hyperactivation of HIF is associated with pathological complications, such as the development of clear-cell renal cell carcinoma (ccRCC), the most common form of kidney cancer. In particular, overexpression of HIF2alpha has been intimately linked to …
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Measurement of cyclic nucleotides in human sperm: experimental and clinical application
… between basal cyclic nucleotide levels, sperm hyperactivation and fertilisation rates at IVF.<br/><br/>Furthermore, this study aimed to apply the HPLC method in conjunction with a high throughput screening strategy and established in vitro tests to identify and characterise the action of …
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The role of IL-17a in the rescue of ASD-like behavioral phenotypes following immune stimulation in a mouse model of neurodevelopmental disorders
… Behavioral rescue was correlated with reduced hyperactivation in the primary somatosensory cortex dysgranular zone (S1DZ), a region that has been previously shown to be tightly linked to MIA behavioral phenotypes. Consistent with the selective effects of LPS within MIA offspring, this reduction …
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Structural and functional aspects of sperm after transit through the fallopian tube of the sheep
… attention was focussed on the incidence of hyperactivation after transit through the Fallopian tube. The term hyperactivation has been used to describe the frantic movement of sperm before they undergo the acrosome reaction and often serves as a biological marker for capacitation. Motility …
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Structural and Functional Analysis of HIV-1 Nef Activation of PAK-2
… in the LHKF structure resulted in PAK-2 hyperactivation. While the I187 substitution in LHKF completely ablated PAK-2 activity. In stark contrast, I187 in the FFHH variant resulted in hyperactivation. Thus, subtle changes in amino acid composition can dramatically affect kinase activation …
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The Use of Ceftiofur Sodium in the Extension and Cooled Storage of Equine Semen: Its Effects on Motion Characteristics, pH, Osmolality, and Bacterial Growth
… are consistent with a trend toward spermatozoal hyperactivation. Stepwise, multiple regression analysis revealed pH was the strongest indicator for the increased motion characteristics, but it was only a minor predictor. There was no significant effect of extender noted for MOT, PM, DAP, DSL, …
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Towards an understanding of the role of Ca2+ signalling in neural stem cell activation
… can be triggered into proliferation by brain hyperactivation. I have found that hyperactivation of astrocytes, but not neurons, triggers cell cycle re-entry in the adult Drosophila brain. The cells that re-enter the cell cycle are mostly glia. However, these cells are arrested in the cell …
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Neural Regions Affecting Female Aggression and Receptivity in Drosophila melanogaster
… neural manipulation. More specifically, hyperactivation of a subset of neurons expressing the doublesex gene was found to incite high amounts of aggression in females but not males. Furthermore, the aggression demonstrated by these females differed based on the stimulus presented by the …
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A functional neuroimaging family study of facial emotion perception in schizophrenia
… unaffected relatives compared to controls, and hyperactivation in relatives for frontal regions involved in emotion processing. Our results suggest that activation abnormalities during facial emotion perception represent genetic vulnerability markers for schizophrenia, and may be accompanied by …
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Macromolecular Complexes of Cystic Fibrosis Transmembrane Conductance Regulator Alter Fluid Transport in inflammatory Bowel Disorders
… the plasma membrane. This action triggers the hyperactivation of CFTR chloride channels and causes secretory diarrhea phenotype in IBD. Inhibition of CFTR and iNOS activity attenuates diarrhea in dextran sodium sulfate (DSS) induced colitis. Dissolution of the macromolecular complex in Nherf2 …
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Cochlear Sensitization to Aminoglycosides: Defining the Role of JAK-STAT Signaling
… injury, whereas chronic developmental hyperactivation perturbs auditory circuit refinement. Together, these studies indicate that JAK2 signaling is context dependent: reduced JAK2 activity sensitizes the mature cochlea to aminoglycoside injury, whereas chronic developmental …
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Characterization of The Roles of Carma3 and Bcl10 In Virus-Triggered Rig-I/Mavs Signaling Pathway
… partially defective NF-κB activation but hyperactivation of TBK1-IRF3 signaling pathway upon ssRNA virus infection. It led to less production of IL6 but more production of type I IFNs and resulted in CARMA3-deficient mice more resistant to virus infection, including VSV and H1N1 influenza …
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Investigating PLEKHS1 adaptor function in PI3K signalling and human cancer biology
… survival, growth and metabolism. Oncogenic hyperactivation of the pathway occurs across tumour types, commonly via genetic alterations in key pathway genes (e.g., *PIK3CA*, *PTEN*). Despite extensive research, the primary drivers of healthy or oncogenic PI3K signalling *in vivo* are largely …
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