Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 45 for “"Hydroxyurea"”.
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Impact of Hydroxyurea on Neurocognitive Function and Quality of Life in Children with Sickle Cell Anemia
… multi-center TCD with Transfusion Changing to Hydroxyurea (TWiTCH) randomized controlled trial established that after a year of monthly blood transfusion, children with abnormal TCD velocities can safely transition to oral hydroxyurea for primary stroke prevention. However, the effect of this …
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A Meta-Analysis of Hydroxyurea Use for β-thalassemia: Implications for Clinical Practice and Medical Education
… of the problems associated with current therapy. Hydroxyurea (HU), an oral chemotherapeutic drug, is expected to increase hemoglobin, thereby minimizing the burden of blood transfusion and its complications. The objective of this study was to conduct a systematic review and meta-analysis to …
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Examining the Effect of Hydroxyurea Treatment on Acute Care Spending and Utilization among Patients with Sickle Cell Disease
… often with particularly high emergency care use. Hydroxyurea (HU), an inexpensive therapeutic drug, has proven to be effective at reducing pain crises. However, HU is underutilized for a variety of reasons including lack of insurance coverage, misperceptions and negative beliefs, and lack of …
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Predictors Of Use Of Hydroxyurea And Its Impact On Clinical And Economic Outcomes Among Children With Sickle Cell Disease
… assess the prevalence and predictors of use of hydroxyurea (HU) and its impact on clinical and economic outcomes in pediatric patients with sickle cell disease (SCD) enrolled in Medicaid. Methods: A cohort of patients with SCD was identified in 2006 using ICD-9-CM codes from Medicaid claims from …
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Study of genetic modifiers of fetal hemoglobin and mechanisms of hydroxyurea-induced γ-globin expression in sickle cell disease
… 2) to investigate the molecular mechanisms of hydroxyurea (HU)-induced production of HbF using a primary erythroid cell model from hematopoietic stem cells (HSCs) derived from umbilical cord blood and lastly, 3) to investigate the prevalence of SCD-related polymorphisms; β-globin gene …
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Pharmacogenomics of sickle cell disease therapeutics: pain and drug metabolism associated gene variants and hydroxyurea-induced post-transcriptional expression of miRNAs
… penicillin prophylaxis, blood transfusions, hydroxyurea, and hematopoietic stem-cell transplantation can dramatically improve survival and quality of life for patients with SCD. However, our understanding of the role of genetic and clinical factors in explaining the complex phenotypic …
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Bovine parvovirus and bovine enterovirus in mixed infections
Bovine fetal spleen cells synchronized with 2mM hydroxyurea were infected with bovine parvovirus and bovine enterovirus in order to study the events occurring when DNA and RNA viruses mixedly infect single cells. The objectives of this research were threefold. First, to determine the effects of …
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Metabolic Modulation Of Mammalian Dna Excision Repair
… Repair incorporation doubled in the presence of hydroxyurea. Thirdly, the enhanced repair replication induced by the poly(ADP-ribose) polymerase inhibitor, 3-aminobenzamide, (3-AB), could not be correlated either with an increased rate of repair in the presence of 3-AB or with the use of …
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The role of recombinational repair in the mechanism of killing during thymine starvation in Escherichia coli
… other cases of abnormal replication, such as in hydroxyurea-treated cells, which are starved for all four DNA precursors but displayed a static rather than lethal effect. While doing so, I discovered the instability of hydroxyurea in solution and identified the decomposition products. In this …
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Clinical pharmacokinetics of low dose paclitaxel in Asian patients with nasopharyngeal carcinoma
… in clinical use. Chemotherapy, consisting of hydroxyurea, paclitaxel and 5-flourouracil were given concurrently with radiotherapy during the first, fourth and seventh week of the treatment. Plasma paclitaxel concentrations were determined by a validated HPLC method and the sparse data were …
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Rhabdomyolysis-induced Acute Kidney Injury in Sickle Cell Disease
… use of antioxidants (TEMPOL, ferrostatin-1, and hydroxyurea) and iron chelators (deferiprone and, potentially, hydroxyurea) were able to ameliorate renal iron accumulation, oxidative stress, lipid peroxidation, and rhabdomyolysis-induced AKI in SS mice. These findings provide evidence that free …
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Uncovering Phosphorylation Circuitries that Control DNA Replication Fork Dynamics
… PP2Cδ and Wip1) to be an important regulator of hydroxyurea induced replication stress. PPM1D negatively regulates kinase signaling by dephosphorylating many DNA replication and repair associated proteins. One such protein called RAP80 is a direct target of PPM1D. I demonstrate that PPM1D …
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Mcm10 regulates the turnover of DNA polymerase alpha.
… resulted in reduced viability after exposure to hydroxyurea, a drug that causes replication fork stalling. This suggests that the DNA binding activity of Mcm10 is important in vivo for fork stabilization during replication stress. In addition to its DNA binding activity, work from our laboratory …
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HMO2, a yeast HMGB protein that preferentially binds to DNA ends
… have slower growth phenotype in presence of hydroxyurea thus indicating that HMO2 might play important role in recovery of stalled DNA replication forks.
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The Ultrastructural and Abnormal Calcium Handling in Pulmonary Vein Sleeve Cells, Atrial and Ventricular Myocytes During Ageing
… attempted to induce ageing chemically with hydroxyurea (HU) in neonatal rat ventricular myocytes (NRVMs). HU inhibited pacing ability, induced autophagy and increased inducible ROS. Although some changes in chemically ageing model were similar to those in aged PVCs, further studies are …
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Machine Learning Approaches and Web-Based System to the Application of Disease Modifying Therapy for Sickle Cell
… shown the beneficial effects of a drug called hydroxyurea/hydroxycarbamide in modifying the disease phenotype. The clinical management of this disease-modifying therapy is difficult and time consuming for clinical staff. This includes finding an optimal classifier that can help to solve the …
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A Novel Phosphorylation Site in the Telomeric Protein TRF2 is Regulated by the ATR Kinase and Plays a Role in Relieving Replication Stress at the Telomere
… sensitive manner. Phosphorylation is induced by hydroxyurea (HU) and ultraviolet (UV) radiation but not Ionizing Radiation (IR). Knockdown studies indicate that ATR is the primary kinase responsible for TRF2 S368 phosphorylation, while the mTOR kinase is implicated as a negative regulator of the …
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Baculovirus as a gene delivery and expression vector in mammalian cells
… to 10-fold in the presence of sodium butyrate or hydroxyurea alone and significantly improved egfp (enhanced green fluorescence protein) expression (~40-fold) when both chemicals were used in combination. Subsequently, in the second part of this study an in vitro culture model was developed and …
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Identification and characterization of novel genes involved in DNA double strand break repair process in the yeast Saccharomyces cerevisiae
… increased sensitivity to DNA damaging agents Hydroxyurea (HU) and bleomycin. Our follow-up genetic studies suggested a role for PPH3/PSY2 phosphatase complex in the NHEJ process through interaction with checkpoint kinases Rad53 and Chk1. We also propose a novel role for yeast uncharacterized …
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The effect of replication impediments on differentiation
… perturbed using DNA damaging agents, low dose hydroxyurea and G-quadruplex secondary structure stabilisation. DNA damage was induced both in the undifferentiated state and during differentiation. When damage was induced during differentiation, greater levels of cell death were seen and there …
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