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Showing 1 to 7 of 7 for “"Hydroxysteroid Dehydrogenases"”.
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Influence of Cellular Localization on Activity of Hydroxysteroid Dehydrogenases
Hydroxysteroid dehydrogenases (HSDs) catalyze the interconversion of inactive steroids and active hormones. HSDs use nicotinamide cofactors in the cytosol and endoplasmic reticulum (ER) lumen to either reduce or oxidize their steroid substrates. Our lab has extensively studied the 17beta-HSDs types …
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Steroid metabolism in the human gut by microbial hydroxysteroid dehydrogenases
… the oxidoreduction of steroid hydroxyl groups by hydroxysteroid dehydrogenases (HSDHs). Pairs of HSDHs can reversibly epimerize α-hydroxyl groups through an oxo-intermediate to β-hydroxyl groups. These small modifications of steroid structure often greatly influence their physicochemical …
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ΚΙΝΗΤΙΚΗ ΜΕΛΕΤΗ ΚΑΙ ΑΝΑΛΥΤΙΚΕΣ ΕΦΑΡΜΟΓΕΣ ΕΝΖΥΜΙΚΩΝ ΣΥΣΤΗΜΑΤΩΝ ΓΙΑ ΤΟΝ ΠΡΟΣΔΙΟΡΙΣΜΟ ΧΟΛΙΚΩΝ ΟΞΕΩΝ ΣΕ ΒΙΟΛΟΓΙΚΑ ΥΓΡΑ
… (B-NAD+) OR BY B-NADP+ IN THE PRESENCE OF HYDROXYSTEROID DEHYDROGENASES (HSD) AND ON THE FLUORIMETRIC MONITORING OF THE PRODUCED NADH OR NADPH. THE PRESENT DISSERTATION CONTRIBUTES TO THE EXTENSION OF OUR KNOWLEDGE ENZYMATIC SYSTEM OF HSD WITH B-NAD+ AND B-NADP+ USING BILE ACIDS AS …
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Corticosteroid hormone action in the cardiovascular system
… hormone action and metabolism by 11β- hydroxysteroid-dehydrogenases (11β-HSDs) in isolated adult rat cardiomyocytes (CM) and cardiac fibroblasts (cFb). We have detected 11β-HSD1 expression and activity in CM and cFb where it facilitates glucocorticoid hormone action, whereas 11β-HSD2 …
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Characterization of enzymatic pathways involved in cortisol and bile acid metabolism by the gut microbiota
… affect endocrine functions. Bacterial hydroxysteroid dehydrogenases (HSDHs) have the potential to significantly alter the physicochemical properties of bile acids with implications for increased/decreased toxicity for gut bacteria and the host. We located a gene-cluster in Eggerthella …
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Anaerobic degradation of steroid hormones by novel denitrifying bacteria
… decarboxylase, and several hydroxysteroid dehydrogenases that might be involved in anaerobic estradiol degradation. These initial results represent a prerequisite for a detailed characterization and elucidation of the estradiol degradation pathway in this novel denitrifying …
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Estrogen sulfotransferase (sult1e1) expression and function in mcf10a-series breast epithelial cells: role as a modifier of breast carcinogenesis and regulation by proliferation state
… steroid sulfatase (STS), aromatase (CYP19), 17β-hydroxysteroid dehydrogenases (17βHSD1 and 2), CYP1B1, and catechol-O-methyltransferase (COMT) in an MCF10A-derived lineage cell culture model for basal-like human breast cancer progression and in ERα-positive luminal MCF7 breast cancer cells. Low …