Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"Hydroxypropyl methylcellulose (HPMC)"”.
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A Study of HPMC-PEG Matrix as Drug Carrier in Spray Congealing
… Screening of the additives showed that hydroxypropyl methylcellulose (HPMC) was an appropriate matrix modifier for PEG. The impact of grade and concentration of HPMC on the physicochemical properties of the molten mixtures, drug (metronidazole), PEG matrix and spray congealed …
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Clarithromycin nanocrystals for high-dose inhalation
… while retaining good flow and dispersion. Hydroxypropyl methylcellulose (HPMC) served as a dual-function excipient, stabilising nanocrystals during milling and acting as the spray-drying matrix, enabling low excipient load. Adding a citric acid/NaOH buffer (pH 5) markedly improved …
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Investigating Crystallization Tendency, Miscibility and Molecular interactions of drug-polymer systems for the development of amorphous solid dispersions
… polyethylene glycol (PEG), eudragit EPO (EPO), hydroxypropyl methylcellulose (HPMC) and polyvinyl pyrrolidone (PVP)] in various drug-polymer ratios were determined by using modulated differential scanning calorimetry (MDSC). Thermal analysis i.e. glass transition temperature (Tg), crystallinity …
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Effect of nano- fillers on tensile properties of biopolymer films
… to the polymers, konjac glucomannan (KGM), hydroxypropyl methylcellulose (HPMC), and zein to investigate their effect on tensile properties of composite films. Tensile properties were measured by dynamic mechanical analysis (DMA) obtaining stress (σ), strain (γ), and Young’s modulus (E). …
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The use of roller compaction as granulation method for hydrophilic extended release matrix tablets
… of roller compaction as granulation method for hydroxypropyl methylcellulose (HPMC) based hydrophilic extended release matrix tablets. Roller compaction is a dry granulation method where powder material is fed through a hopper between two counter-rotating rolls and pressed into a ribbon like …
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A thermal/thermo-mechanical and imaging study of component distribution and interaction in pharmaceutical film coats
… (MCT) were incorporated as plasticizers while hydroxypropyl methylcellulose (HPMC) was utilized as the pore forming agent. The thermal, thermo-mechanical and phase distribution of EC films incorporated with plasticizers and/or HPMC were investigated using MTDSC, DMA and localized thermal …
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Drug-Polymer and Drug-Lipid Miscibility for the Development of Amorphous Solid Dispersions and Solid Lipid Nanoparticles
… SDs included polyvinylpyrrolidone K90 (PVP), hydroxypropyl methylcellulose (HPMC), eudragit (EPO), and polyethylene glycol 8000 (PEG). Miscibility of drug and polymer at 90:10, 70:30, and 50:50 w/w (drug:polymer) was assessed through modulated differential scanning calorimetry (MDSC). FLT SDs …
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Nanoemulsion-Loaded Hydrogels For Advanced Pharmaceutical Formulations
… cores. Second, we design a new thermogelling methylcellulose (MC) nanoemulsion that can be efficiently formulated into composite solid dosage drug products with well-controlled API nanocrystals embedded in a MC matrix. The composite drug products possess a fast and tunable release performance …
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Development of Amorphous Ternary Solid Dispersions of a Novel Anti-Tubercular Indole-2-Carboxamide Derivative with Curcumin/Clofazimine for Tuberculosis Treatment
… (PVP), Eudragit® EPO® (EPO), and hydroxypropyl methylcellulose (HPMC), at 1:1w/w (for binary solid dispersions) and at 1:1:2 w/w/w (for ternary solid dispersions) ratios. The binary and ternary solid dispersions and their respective physical mixtures were characterized for their …
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Formulation and characterisation of novel films for buccal mucosa drug delivery for paediatric patients
… toxicity. Five different film forming polymers hydroxypropyl methylcellulose (HPMC), methylcellulose (MC), sodium alginate (SA), carrageenan (CA) and metolose (MET) were used initially and subsequently with polyethylene glycol (PEG 400) as plasticiser and L-arg (to stabilise OME). Polymeric gels …
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EVALUATION OF HYDROLYTIC ENZYMES IN THE DESIGN OF ORAL DRUG DELIVERY SYSTEMS
… dosage forms having as functional polymer hydroxypropyl methylcellulose (HPMC), a hydrophilic cellulose derivative which is substrate of the enzyme itself. Previous examples of the use of enzymes in drug delivery were investigated through a literature survey, which highlighted their high …
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Investigating the Hydration and Disintegration Mechanisms of Film-Coated Pharmaceutical Tablets
… either a ready-to-use polyvinyl alcohol (PVA) or hydroxypropyl methylcellulose (HPMC) based immediate release formulation or a sustained release formulation based on ethylcellulose. Each of these film coating systems contains various polymers. The film-coated tablet hydration and disintegration …
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Preparation of novel modified-release dosage forms of diclofenac sodium and ibuprofen.
… locust bean and carrageenan gums as well as hydroxypropyl methylcellulose (HPMC) were used as the principle release-retarding agents. Various excipients - lactose, Encompress®, cellulose acetate phthalate (CAP), Veegum F® and Avicel PH101® - were added in different proportions to further …
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Towards a more efficacious treatment for Oropharyngeal Candidiasis (OPC): Hydrogel-forming tablets for the controlled release delivery of Chlorhexidine diacetate
… They were prepared using Poloxamer 407 (P407), hydroxypropyl methylcellulose (HPMC) and either sorbitol, mannitol or xylitol at different ratios. The tablets were investigated for their physical properties, ex vivo mucoadhesion, the rate of hydration, gelling efficiency using image analysis, …