Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 29 for “"Hydroxypropyl methylcellulose"”.
-
Development and characterization of edible films made from four dietary fibers -pectin, guar gum, locust bean gum, and hydroxypropyl methylcellulose
… e.g., guar gum, locust bean gum, pectin, and hydroxypropyl methylcellulose, and glycerol concentration to the mechanical properties and dissolution/ partial dissolution time of their films and the viscosity of their solution. Specifically, it investigates if the higher glycerol and polymer …
-
Physicochemical and tableting properties of crystallised and spray-dried phenylbutazone containing polymeric additives. Effect of polymeric additives (hydroxypropyl methylcellulose and a polyoxyethylene-polyoxypropylene glycol) on the crystalline structure, physicochemical properties and tableting behaviour of crystallised and spray-dried phenylbutazone powders
… low levels of two hydrophilic polymers - hydroxypropyl methylcellulose (H. P. M. C. ) and the surfactant poloxamer 188 - prepared by both conventional crystallisation and spray drying are reported. As an integral nart of the work attempts were mado to identify the different polymorphic …
-
A Study of HPMC-PEG Matrix as Drug Carrier in Spray Congealing
… Screening of the additives showed that hydroxypropyl methylcellulose (HPMC) was an appropriate matrix modifier for PEG. The impact of grade and concentration of HPMC on the physicochemical properties of the molten mixtures, drug (metronidazole), PEG matrix and spray congealed …
-
Clarithromycin nanocrystals for high-dose inhalation
… while retaining good flow and dispersion. Hydroxypropyl methylcellulose (HPMC) served as a dual-function excipient, stabilising nanocrystals during milling and acting as the spray-drying matrix, enabling low excipient load. Adding a citric acid/NaOH buffer (pH 5) markedly improved …
-
Production of stable bcs class ii drug suspensions by melt emulsification and subsequent incorporation into polymer strip films
… optimized fenofibrate suspension is blended with hydroxypropyl methylcellulose film solution and cast into a solid strip film by oven drying. The film is characterized by redispersion and by dissolution rate. Particles are recovered from the films in de-ionized water within 5 minutes with no size …
-
Effect of Emulsifiers and Food Gum on Non Fat Ice Cream
… (S) at 0.15 (S 15), 0.20 (S20), and 0.25% (S25). Hydroxypropyl methylcellulose (H), a food gum, was also added to the same base mix at 3 levels; 0.15 (H15), 0.20 (H20), and 0.25% (H25). A portion of the base mix was retained to serve as the control (C). The C contained no emulsifier or additional …
-
Development and Characterization of Fluocinolone Acetonide Loaded Nanosized Lipid Carriers for Ocular Delivery via Subconjunctival Route: Synergistic Effect of Vitamin a Palmitate
… gel of FA-NLC was developed using gellan gum and hydroxypropyl methylcellulose as gelling agents. In situ gels were characterized for rheological behavior, in vitro release and permeability studies using corneal and scleral tissues. Furthermore, the ocular pharmacokinetic studies of in situ gel …
-
Investigating Crystallization Tendency, Miscibility and Molecular interactions of drug-polymer systems for the development of amorphous solid dispersions
… polyethylene glycol (PEG), eudragit EPO (EPO), hydroxypropyl methylcellulose (HPMC) and polyvinyl pyrrolidone (PVP)] in various drug-polymer ratios were determined by using modulated differential scanning calorimetry (MDSC). Thermal analysis i.e. glass transition temperature (Tg), crystallinity …
-
Effect of nano- fillers on tensile properties of biopolymer films
… to the polymers, konjac glucomannan (KGM), hydroxypropyl methylcellulose (HPMC), and zein to investigate their effect on tensile properties of composite films. Tensile properties were measured by dynamic mechanical analysis (DMA) obtaining stress (σ), strain (γ), and Young’s modulus (E). …
-
The use of roller compaction as granulation method for hydrophilic extended release matrix tablets
… of roller compaction as granulation method for hydroxypropyl methylcellulose (HPMC) based hydrophilic extended release matrix tablets. Roller compaction is a dry granulation method where powder material is fed through a hopper between two counter-rotating rolls and pressed into a ribbon like …
-
Solubility Enhancement and Precipitation Inhibition of Poorly Water Soluble Compounds Utilizing Hot Melt Extrusion Technology
… to the high energy amorphous state of PTX. 5% hydroxypropyl methylcellulose acetate succinate (HPMCAS-LF) successfully postponed the precipitation and maintained the solubility up to 12 hours by forming hydrogen bonds with PTX. This finding was confirmed by FT-IR analysis. </p>
-
A thermal/thermo-mechanical and imaging study of component distribution and interaction in pharmaceutical film coats
… (MCT) were incorporated as plasticizers while hydroxypropyl methylcellulose (HPMC) was utilized as the pore forming agent. The thermal, thermo-mechanical and phase distribution of EC films incorporated with plasticizers and/or HPMC were investigated using MTDSC, DMA and localized thermal …
-
Drug-Polymer and Drug-Lipid Miscibility for the Development of Amorphous Solid Dispersions and Solid Lipid Nanoparticles
… SDs included polyvinylpyrrolidone K90 (PVP), hydroxypropyl methylcellulose (HPMC), eudragit (EPO), and polyethylene glycol 8000 (PEG). Miscibility of drug and polymer at 90:10, 70:30, and 50:50 w/w (drug:polymer) was assessed through modulated differential scanning calorimetry (MDSC). FLT SDs …
-
Grewia polysaccharide gum as a pharmaceutical excipient
… may be preferable to gum Arabic or sodium carboxymethylcellulose as a suspending agent in ibuprofen suspension formulations. The release retardant property of the gum was superior to guar and Metolose® in ibuprofen matrices. Similarly, carboxy methylcellulose, Methocel®, gum Arabic or Metolose® …
-
Nanoemulsion-Loaded Hydrogels For Advanced Pharmaceutical Formulations
… cores. Second, we design a new thermogelling methylcellulose (MC) nanoemulsion that can be efficiently formulated into composite solid dosage drug products with well-controlled API nanocrystals embedded in a MC matrix. The composite drug products possess a fast and tunable release performance …
-
Design and Synthesis of Complex and Fluorescent Labeled Cellulose-Based Derivatives for Orally Administered Drug Delivery Systems
… produce fluorescent poly- and oligosaccharides (hydroxypropyl cellulose, hydroxypropyl methylcellulose, and hydroxypropyl beta cyclodextrin). Schiff-base chemistry was then explored to append a commercially available fluorescent label, Nile Blue. Due to the dynamic nature and hydrolytic lability …
-
Development of Amorphous Ternary Solid Dispersions of a Novel Anti-Tubercular Indole-2-Carboxamide Derivative with Curcumin/Clofazimine for Tuberculosis Treatment
… (PVP), Eudragit® EPO® (EPO), and hydroxypropyl methylcellulose (HPMC), at 1:1w/w (for binary solid dispersions) and at 1:1:2 w/w/w (for ternary solid dispersions) ratios. The binary and ternary solid dispersions and their respective physical mixtures were characterized for their …
-
DEVELOPMENT OF SUPERSATURATED MATRIX SYSTEMS FOR POORLY WATER-SOLUBLE COMPOUNDS BASED ON SPRAY-DRIED SOLID DISPERSIONS
… Two types of polymeric carriers, namely hydroxypropyl methylcellulose acetate succinate (HPMCAS) and copovidone S-630, were used in spary-dried dispersion (SDD) formulations. Weak acid drugs glipizide and gliclazide which tend to have limited solubility and dissolution rate were chosen as …
-
Novel Biomaterials for Applications in Cartilage Tissue Engineering
… as well as two chemically modified versions of hydroxypropyl methylcellulose, or HPMC (named HPMC 2,6 and HPMC triple). These materials were analysed at various concentrations (2%, 3%, 5%, and 7% w/v), as opposed to the conventional approach of using a single concentration, to explore the …
-
Formulation and characterisation of novel films for buccal mucosa drug delivery for paediatric patients
… toxicity. Five different film forming polymers hydroxypropyl methylcellulose (HPMC), methylcellulose (MC), sodium alginate (SA), carrageenan (CA) and metolose (MET) were used initially and subsequently with polyethylene glycol (PEG 400) as plasticiser and L-arg (to stabilise OME). Polymeric gels …
Page 1 of 2