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Showing 1 to 20 of 49 for “"Hydroxyproline"”.
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Biochemical Characterization of Hydroxyproline-rich Glycoproteins in the Arabidopsis Root Cell Wall
… It is a member of the plant cell wall hydroxyprolinerich glycoproteins (HRGPs) superfamily and presumably functions by self-assembling into a scaffold that forms a covalently cross-linked wall network. Here, the self-assembly of extensins from Arabidopsis, tomato, tobacco and maize and …
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HYDROXYPROLINE DEHYDROGENASE: A PROMISING TARGET FOR TREATING ALL THREE FORMS OF PRIMARY HYPEROXALURIA
… symptoms of PH, not treating the disease itself. Hydroxyproline metabolism is a potential pathway for treating for PH because it makes a significant contribution to the pool of glyoxylate formed in the body. It has been hypothesized that hydroxyproline dehydrogenase (HYPDH), traditionally referred …
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Synthesis of Labeled 3-Hydroxyproline and Biosynthesis of the Dehydroproline Moiety of Virginiamycin M₁
(R,S)-[Carboxyl-¹⁴C]–cis-3-hydroxyproline was synthesized from S-[carboxyl-¹⁴C] proline. The oxygen functionality at the three position was obtained by acetylation of 1,2-dehydroproline methyl ester using lead tetraacetate. Reduction of the imine with sodium borohydride gave predominately …
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Defining the role of 4-hydroxy-2-oxoglutarate aldolase in hydroxyproline metabolism and primary hyperoxaluria
… evidence has shown that the degradation of 4-hydroxyproline (Hyp), generated from endogenous and dietary sources, leads to an increase in glycolate and oxalate levels in plasma and urine. Furthermore, it has been shown that Hyp metabolism is likely the major contributor to the glyoxylate pool …
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Oligomers of beta-L-arabinosides of hydroxyproline : synthesis of the carbohydrate epitope of the Art v 1 allergen
… by clusters of contiguous â-arabinosides of hydroxyproline – was found to be a key recognition element for antibodies generated in response to the natural protein. This dissertation details the chemical synthesis of oligomers of â-arabinosides of hydroxyproline and the search to establish the …
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The effects of aging and transformation on the DNA, RNA, protein, and hydroxyproline content of fibroblasts (WI 38) in culture
The study of the aging process is the investigation as to how the passage of time affects cells, organs, and organisms. Aging is a very complex and incompletely understood phenomenon. This is reflected by the number of theories attributing aging to a variety of causative factors such as: (1) the …
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The Relationship Between Exercise-Induced Delayed Muscle Soreness and The Excretion of Urine Metabolites and Creatinine, 3-Methylhistidine and Hydroxyproline
… creatinine (CRE), 3-methylhistidine (3MH), and hydroxyproline (OHP) were investigated as indices of muscle damage associated with exercise-induced delayed muscle soreness (DMS). Subjects (n = 28) maintained meat-free diets for six days. Twenty-four hour urine volumes were obtained from each …
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ΣΥΜΒΟΛΗ ΣΤΗ ΜΕΛΕΤΗ ΤΟΥ ΜΕΤΑΒΟΛΙΣΜΟΥ ΤΟΥ ΟΣΤΙΚΟΥ ΚΟΛΛΑΓΟΝΟΥ ΚΑΙ ΤΗΣ ΟΣΤΙΚΗΣ ΕΝΑΛΛΑΓΗΣ ΣΤΗ V.COOLEY ΔΙΑ ΤΟΥ ΠΡΟΣΔΙΟΡΙΣΜΟΥ ΤΗΣ ΥΔΡΟΞΥΠΡΟΛΙΝΗΣ ΟΥΡΩΝ
IN THE PRESENT STUDY, THE AMOUNT OF TOTAL HYDROXYPROLINE EXCRETED IN 24 HR/M2 URINE SAMPLES WAS MEASURED. THE SUBJECTS WERE PATIENTS STRICKEN WITH COOLEY'S ANEMIA (THALASSEMIA MAJOR). EACH SHOWED THE CHARACTERISTIC BONE CHANGES KNOWN AS OSTEOPOROSIS . THE PURPOSE OF THIS STUDY WAS TO RESEARCH THE …
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Integration Of Quantitative And Functional Proteomics To Explore The Global Functional Landscape Of Post-Translational Modifications
… platform, HypDB (https://hypdb.site), for hydroxyproline sites collection and functional annotation, while sharing the knowledge with the community. In the data collecting section, we evaluated the confidence of site-localization for identified sites and quantified their stoichiometry with …
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Factors affecting the accumulation of pentosidine in the skin of wild birds
… 24 California Gulls. Collagen was measured by a hydroxyproline spectrophotometric method and Ps was quantified using reverse phase HPLC. Ps concentration in the skin and foot webbing increased linearly with age (p < 0.001). Measurement of Ps in birds of unknown ages provided age estimates within …
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Growth hormone metabolism in hypopituitary subjects and young, middle-aged and elderly normal subjects
… urinary excretion of creatinine, calcium, hydroxyproline and nitrogen. Subjects were divided into the following groups: (I) 6 hypopituitary subjects 9 - 29 years old; (II) 4 men 23.,...29 years old; (III) 6 middle-aged men 35 - 51 years ol.d; and (IV) 6 elderly subjects 61 - 69 years old. …
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Computational studies on the factors influencing stabilities of collagen-like peptides
… specific aspects: (1) the stabilizing effect of hydroxyproline (Hyp), (2) the destabilizing effect of replacing Gly, and (3) the role of water mediated hydrogen bonds. A better understanding of the origins of the stabilities of collagens will help in the design of new biomaterials and the …
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Synthesis of Non-Steroidal Estrogen Receptor Proteolysis Targeting Chimeric Molecules (Protacs)
… ligase. The synthesis of a tetrahydrofuran-based hydroxyproline analog was attempted with encouraging results. Upon completion of the synthesis, this analog can be attached to an ER ligand in place of the HIF-1alpha destruction sequence and tested as the first non-peptide based PROTAC.
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Effects of restricted growth rate, elevated vitamin and mineral levels and aging on bone growth, histological integrity and biochemical composition of articular cartilage in boars
… age throughout the trial period. Galactose and hydroxyproline levels in cartilage samples from the femur, humerus and radius were generally unaffected by the imposed dietary treatments. Galactose levels were unaffected by age. Hydroxyproline content of cartilage from the radius and humerus …
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Experimental Colonic Obstruction and Anastomotic Healing
… of obstruction the collagen levels, analyzed as hydroxyproline, were substantially depressed proximal to the stenosis. On the other hand, the intestine had the capability to recover after relief of the obstruction since hydroxyproline levels were found to return to normal levels. The parallel in …
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Η ΒΙΟΣΥΝΘΕΣΗ ΤΩΝ ΒΑΣΙΚΩΝ ΜΕΜΒΡΑΝΩΝ ΩΣ ΒΙΟΧΗΜΙΚΟΣ ΔΕΙΚΤΗΣ ΤΗΣ ΑΓΓΕΙΟΓΕΝΕΣΗΣ
… INCORPORATION OF [U-14C]-PROLINE, AS PROLINE OR HYDROXYPROLINE, IN COLLAGEN TYPE IV, WHICH IS THE BASIC CONSTITUENT OF BM. COLLAGEN TYPE IV SYNTHESIS OF THE NEWLY FORMED BM WAS ESTIMATED EITHER BY MEASURING [U-14C]- HYDROXYPROLINE, OR BY MEASURING COLLAGENOUS PROTEIN DEGRADATION PRODUCTS, …
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Exercise induced damage to skeletal muscle and connective tissue
… (serum type 1 collagen concentration and plasma hydroxyproline) following concentric and eccentric exercise protocols indicated that connective tissue breakdown may accompany eccentric exercise-induced muscle damage. Further analysis of collagen breakdown products in urine (pyridinoline, …
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Dietary calcium and cation-anion difference influences calcium status and bone remodeling in exercising and sedentary Arabian horses
… parathyroid hormone (PTH), osteocalcin, and hydroxyproline. Radiographs of the left third metacarpal bone were taken. An aluminum step wedge exposed simultaneously was used as a reference standard for estimating bone mineral content (BMC) with an image analysis program. Bone measurements, …
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Total synthesis of a virotoxin and analogs for conformational studies
… analogs containing L-proline (Pro), trans-3-hydroxyproline (3-Hyp) or cis-4-hydroxyproline (4-hyp) residue substituting for 2,3-trans-3,4-trans-dihydroxyproline in the natural product. We report herein an efficient strategy that provides a dipeptide containing a (2S,4S)-4,5-dihydroxyleucine …
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