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Showing 1 to 3 of 3 for “"Hydroxymethylglutaryl CoA Reductases"”.
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Variations in Mevalonate Pathway Flux in Human Cells with Familial Hypercholesterolemia
The general metadata -- e.g., title, author, abstract, subject headings, etc. -- is publicly available, but access to the submitted files is restricted to UT Southwestern campus access and/or authorized UT Southwestern users.
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Sequential Actions of VCP/p97 and the Proteasome 19S Regulatory Particle in Sterol-Accelerated, ER-Associated Degradation of HMG CoA Reductase
… of the cholesterol biosynthetic enzyme HMG CoA reductase results from its sterol-induced binding to ER membrane proteins called Insig-1 and Insig-2. This binding allows for subsequent ubiquitination of reductase by Insig-associated ubiquitin ligases. Once ubiquitinated, reductase becomes …
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Utilizing Drosophila S2 Cells as a Model System to Determine Underlying Mechanisms of ER-associated Degradation
… the ERAD of integral membrane proteins, HMG CoA reductase and Insig-1. These are ideal model substrates since their ERAD is strictly regulated by lipids, which helps guard against artifacts when various aspects of the reactions are reconstituted in model systems or in vitro. I utilized …