Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 16 of 16 for “"Hydroxychloroquine"”.
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A systematic review of the efficacy of hydroxychloroquine in COVID-19 patients
<p>Hydroxychloroquine is a highly effective and commonly used disease-modifying anti-rheumatic drug (DMRD) for the treatment of various autoimmune diseases. Recently this medication received lot of attention in the medical world as a potential treatment for COVID-19. The goal of this research is to …
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Copper ionophores induce autophagy in melanoma cells.
… for viability with the autophagy inhibitor hydroxychloroquine, both ionophores showed evidence of synergism. To further study the migration of copper, STEM-EDX was used on thiomaltol treated melanoma cells.
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Directed Evolution of Macrocyclic Peptides For Inhibition of Autophagy
… in many cancer types. Chloroquine (CQ) and hydroxychloroquine (HCQ), two autophagy inhibitors in clinical trials, suffer from poor pharmacokinetics and high toxicity at therapeutic dosages. This has prompted intense interest in the development of targeted autophagy inhibitors to re-sensitize …
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Development of novel strategies to combat multidrug resistance mediated by efflux transporters and intracellular bacteria
… strategy was expanded to the antimalarial drugs hydroxychloroquine, quinine, mefloquine and primaquine in an effort to inhibit PfCRT. A quinine dimer, Q2, blocked PfCRT mediated efflux and successfully cleared parasitemia <em>in vivo</em> in a <em>Plasmodium berghei</em>mice model.Efforts to …
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Structure-Based Drug Design Against a Biosecurity Pathogen
… However, extended combinatorial treatment with hydroxychloroquine is required to manage chronic Q-fever. As a result, there is interest in developing novel anti-Coxiella inhibitors. Here, we approach this challenge from two directions. Firstly, 2-methylisocitrate lyase is identified as a …
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Autophagy mechanisms in sputum and peripheral blood cells of patients with severe asthma: a new therapeutic target
… (LY29400 and 3-methyladenine [3-MA]) and hydroxychloroquine (HCQ) were used. Knockdown of ATG5 and Beclin-1 was performed in A549 cells, and the therapeutic effects of dexamethasone were evaluated. Results: Higher autophagy levels were noted in sputum granulocytes, PBCs, and PBEs from …
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Analysis of Information Diffusion through Social Media
… more than 700,000 tweets containing keywords of Hydroxychloroquine and chloroquine, two candidate medicines, to prevent and cure patients infected with COVID-19. We show that people's opinions are concentrated in the case of polarity and spread out in the case of subjectivity. Also, they tend to …
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Evaluating Treatment of Antiphospholipid Syndrome during Pregnancy with Knowledge Synthesis Methods
… weight heparin; and 3. Chloroquine and hydroxychloroquine). Results and Conclusion: There was no significant increase in malformations in the statin exposed pregnancies. However, there was a small but significant increase in spontaneous abortions. It is not clear if this is due to the …
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Hsp27 and Chemotherapy-Induced Autophagy As Biomarkers In Osteosarcoma
… In LM7 cells, autophagy inhibition with hydroxychloroquine (HCQ) prior to chemotherapy resulted in a trend towards decreased viability consistent with a cytoprotective role of autophagy. In CCH-OS-D cells, autophagy inhibition prior to DOX significantly decreased chemosensitivity …
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An Exploration of Ambulatory Visits and Medications Prescribed for Patients Diagnosed with Lupus Erythematosus in the United States
… The most common medications prescribed were hydroxychloroquine (30%), prednisone (23%), multivitamin (14%), and furosemide (9%). Variables that were found to be significant were physician degree type (<em>p=0.014</em>), practice ownership status (<em>p=0.007</em>), patient status (new or …
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MicroRNA-mediated Attenuation of Inflammation in NZB/W Lupus Mice
… miRNAs in female NZB/W mice treated with hydroxychloroquine (HCQ) or prednisone (PRED) for 12 weeks beginning at 20 weeks-of-age. We found that treatment with HCQ or PRED induced unique changes to miRNA expression in multiple tissues. In order to identify specific miRNAs as …
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STATIC AND DYNAMIC FORMS TO IDENTIFY DDI POTENTIAL AND SOURCES OF PHARMACOKINETIC VARIABILITY
… to determine if COVID-19 impacts the exposure of hydroxychloroquine and its metabolite desethylhydroxychloroquine, using physiologically based pharmacokinetic (PBPK) modeling, and Specific Aim 3: to optimize clinical trial design to capture hydroxychloroquine 3-compartment pharmacokinetics by …
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Clinical importance of autophagy dependency and inhibition in cancer treatment
… in over 90 clinical trials using FDA- approved hydroxychloroquine (HCQ) alone or in combination with other therapies. However, responses have been variable, especially in trials where HCQ is used as a monotherapy. Further, the relationship between HCQ pharmacokinetics and pharmacodynamics is not …
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The Role of Autophagy In The Sensitivity of Osteosarcoma Cells to Gemcitabine Treatment
… inhibition by either the pharmacologic inhibitor Hydroxychloroquine or genetic inhibition of BECN and ATG5 resulted in either increased or decreased sensitivity of OS cells to gemcitabine depending on the cell line tested. Specifically, the sensitivity of LM7 cells to GCB was greatly enhanced …
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Evaluation of the role of autophagy in ovarian cancer chemoresistance
… clinical trials that are currently incorporating hydroxychloroquine without any guidance on the contribution of autophagy to the tumour phenotype. It is likely that biomarkers will be needed to guide the administration of autophagy inhibitors in the future. Here, we have made potentially …
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An NLP Analysis of Health Advice Giving in the Medical Research Literature
… to retrieve health advice regarding the use of hydroxychloroquine (HCQ) as a treatment for COVID-19 from LitCovid, a large COVID-19 research literature database curated by the National Institutes of Health.</p> <p>An evaluation of sentences extracted from both abstracts and discussions showed …