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Showing 1 to 8 of 8 for “"Hydrophilic interaction liquid chromatography"”.
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Synthesis & retention mechanisms of novel mixed mode stationary phase for detection of specific polar low molecular weight biological samples
… of novel mixed mode stationary phases for Hydrophilic Interaction Liquid Chromatography (HILIC). HILIC is a rapidly emerging chromatographic mode that is finding great applicability in the analysis of polar organic molecules. In addition, there is a chapter on the analysis of Bisphenol A …
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Development of a novel cyanide-free method for analysis of vitamin B₁₂ in milk-based infant formula
… α-ribazole was collected by boronate affinity chromatography and concentrated by lyophilisation. α-Ribazole was identified and characterised by nuclear magnetic resonance spectroscopy and liquid chromatography mass spectrometry to demonstrate its suitability as a standard. This protocol was …
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Studies of UHPLC-MS performance and application to rapid sensitive and robust drug analysis
… comprises studies of ultra high performance liquid chromatography (UHPLC) performance with a particular focus on the application of liquid chromatography-mass spectrometry (LC-MS) for the analysis of basic drugs. UHPLC-MS technologies are investigated to facilitate fast, sensitive and robust …
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The Development and Application of Non- Targeted Mass Spectrometry Based Methods to Tea (Camellia Sinensis L.)
… pace with on-going technological advances in chromatography and mass spectrometry. Thus a major goal of this thesis was to develop improved, non-targeted methods using modern LChigh resolution mass spectrometry (HRMS) instrumentation and then explore their utility in investigating complex …
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Targeted and untargeted metabolomic profiling of human serum, urine and brain by liquid chromatography mass spectrometry (LC-MS)
… amination method was used in combination with hydrophilic interaction liquid chromatography and high resolution mass spectrometry to analyse the sugars in post-mortem human brain. The samples were collected from six control brain samples and eighteen samples from individuals who had suffered …
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Applications of LC-MS/MS in forensic toxicology for the analysis of drugs and their metabolites
… LC-MS method for these metabolites using a novel hydrophilic interaction liquid chromatography column was validated and applied to routine forensic casework. Ninety urine case samples were divided into three groups depending on the ethanol concentration found in blood and analysed by the developed …
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Discovery of Quinic Acid Derivatives as Oral Anti-inflammatory Agents
… analog KZ-41, we developed and validated a novel hydrophilic interaction liquid chromatography–tandem mass spectrometry (HILIC-MS/MS) analytical assay. An analog of KZ-41 was used as internal standard (IS). KZ-41 and the IS were obtained by protein precipitation and separated by HILIC …
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New thin shell silica particles and HILIC phases for liquid chromatography: synthesis, characterisation and functionalisation
For the past decade, there has been a steady growth of interest in the use of superficially porous particles with a solid core and a porous shell (also known as fused core, core-shell or porous shell) for fast and highly efficient separation of low molecular weight solutes to large and complex …