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Showing 1 to 20 of 189 for “"Hydrolase"”.
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Dextran hydrolase produced by Streptococcus mutans
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Constitutive Overexpression of Acyloxyacyl Hydrolase in Mus Musculus
Acyloxyacyl hydrolase (AOAH) is a highly conserved host lipase that selectively removes the secondary acyl chains from lipid A, the bioactive center of Gram negative bacterial lipopolysaccharide (LPS). Deacylated LPS has a marked reduction in bioactivity and antagonizes the LPS signaling pathway. …
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Biochemical investigation of the ubiquitin carboxyl-terminal hydrolase family
… the active site of Ubiquitin Carboxyl Terminal Hydrolase (UCH) deubiquinating enzymes (DUBS) help regulate these enzymes interaction with the ubiquitin. I will provide evidence that the putative oxyanion glutamine does function contribute to stabilization of the oxyanion intermediate. Secondly, …
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High-throughput screening for ADP-ribosyl hydrolase 3 inhibitors
Poly(ADP-ribose) (PAR) signaling is an important component of DNA damage repair, DNA replication, and initiation of parthanatos, a method of controlled cell death. While PAR has been well studied for decades, much is still unknown about PAR’s initiation of parthanatos and the importance of …
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Synthesis of Chemical Models of Hydrolase Enzymes for Intramolecular Catalysis.
… enzymes' active sites. However, there are some hydrolase enzymes (including nucleases) that can function without the aid of metal ions. 2,6-Di(1<em>H</em>-imidazol-2-yl)phenol, a model compound for hydrolase enzyme, was synthesized by the reaction between ethylenediamine and …
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Acyloxyacyl Hydrolase: Studies on Its Regulation and Function in Mus Musculus
Acyloxyacyl hydrolase (AOAH) is an enzyme that detoxifies Gram-negative bacterial lipopolysaccharides (LPS) by selectively removing secondary acyl chains from the lipid A moiety. Originally found in neutrophils, it is also produced by monocyte-macrophages and renal proximal tubule cells. In the …
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Functional study of ubiquitin C-terminal hydrolase-L1 gene promoter haplotypes
… neuron specific Ubiquitin Carboxyl-Terminal Hydrolase-L1 (UCH-L1) is intimately involved with the UCS – both in a hydrolase and ligase capacity. Mutations in UCH-L1 have clearly been associated with various neurodegenerative disorders, including Alzheimer’s, Huntington’s and particularly …
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Molecular Considerations In The Design Of Novel Alpha/Beta Hydrolase Inhibitors
Alpha/beta hydrolases (ABHs) are a superfamily of hydrolytic enzymes that process a wide variety of substrates. A subfamily of ABHs called carboxylesterases (CEs) are important enzymes that catalyze biological detoxification, hydrolysis of certain pesticides, and metabolism of many esterified …
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Studies on the pyruvate dehydrogenase phosphatase and 3-hydroxyisobutyryl-CoA hydrolase
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Degradation of atrazine utilizing triazine hydrolase (TrzN) from Arthrobacter aurescens TC1
Triazine hydrolase (TrzN) from Arthrobacter aurescens TC1 is a Zn(II) dependent hydrolytic dehalogenase from the amidohydrolase super family. TrzN has 22 unique substrates. Most notably, TrzN can hydrolytically dechlorinate atrazine (2-chloro-4-ethylamino-6-isopropylamino-s-triazine) to its less …
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Role of Nudix-Hydrolase ASMTL in Modulating Mitochondrial Biogenesis of Cancer Cells
Cancer cells have enhanced DNA biosynthesis, rendering them susceptible to nucleotide modifications that enter the cellular nucleotide pool during repair or DNA degradation. These modified nucleotides can then be incorporated into newly synthesized DNA, resulting in random mutations or, when …
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Exploring the emergence of pesticide degradation in the α/β hydrolase superfamily
… The starting point of this study is the α/β hydrolase P91. This enzyme was recently identified in a functional metagenomic screening and displays weak promiscuous phosphotriesterase (PTE) activity. P91’s PTE activity is remarkable because, in contrast to other currently known PTEs, it …
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The Impact of Depleting the Essential Bacterial Enzyme Peptidyl-tRNA Hydrolase on Translation
Peptidyl-tRNA hydrolase (Pth) is an essential bacterial enzyme that recycles peptidyl-tRNAs (pep-tRNAs) by hydrolyzing the ester bond between the tRNA and the peptide. The best-characterized function of Pth is salvaging free pep-tRNAs that dissociate from the ribosome during translation to prevent …
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Identification of Acyloxyacyl Hydrolase, a Lipopolysaccharide Detoxifying Enzyme, in the Murine Urinary Tract
Acyloxyacyl hydrolase (AOAH) is a lipase that removes the secondary fatty acyl chains that are substituted to the hydroxyl groups of glucosamine-linked 3-hydroxyacyl residues in lipid A, the bioactive center of Gram-negative bacterial lipopolysaccharides (LPS). Such limited deacylation has been …
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Characterization of a bifunctional cell wall hydrolase in the mobile genetic element ICEBsJ
… not all ICEs encode an enzyme with peptidoglycan hydrolase function that is involved in transfer. While these hydrolases are widespread, they are some of the least-studied components of conjugative transfer systems, and very little is known about their function. The integrative and conjugative …
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Development and Application of a High-Throughput Assay for Discovery of Starch Hydrolase Inhibitors
… for rapidly measuring the inhibition of starch hydrolase was developed, by monitoring the decrease in turbidity over time during the enzymatic digestion of starch. By applying HTS, extracts of wild buckwheat root exhibited strong starch hydrolase inhibitory activity, and diboside A was isolated …
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Investigating Endocannabinoid Metabolism in Alcohol Use Disorder: a focus on fatty acid amide hydrolase (FAAH)
The endocannabinoid enzyme, fatty acid amide hydrolase (FAAH), has been proposed as a therapeutic target for Alcohol Use Disorder (AUD) and psychiatric illnesses. Studies suggest that FAAH regulates alcohol intake/preference, and its impairment increases risk for alcohol use disorder (AUD). This …
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Characterization of BphD, a C-C bond hydrolase involved in the degradation of polychlorinated biphenyls
… product (MCP). BphDLB400 (EC 3.7.1.8), the MCP hydrolase from the biphenyl degradation pathway of Burkholderia xenovorans LB400, hydrolyzes 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate (HOPDA) to 2-hydroxypenta-2,4-dienoate (HPD) and benzoate. Although MCP hydrolases contain the catalytic triad …
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