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Showing 1 to 14 of 14 for “"Hydrofunctionalization"”.
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Development of Copper(I) Hydride-Catalyzed Asymmetric Olefin Hydrofunctionalization Reactions
… hydride (CuH)-catalyzed enantioselective hydrofunctionalization reactions of olefins. The first chapter highlights a method on CuH-catalyzed asymmetric hydroamination of strained trisubstituted alkenes, including cyclobutenes and cyclopropenes. The second chapter presents an approach for …
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Mechanistic Elucidation of M-PR2NRʹ2 Catalysts for Hydrofunctionalization and Cross Coupling Reactions
… utilized for organic transformations. Alkyne hydrofunctionalization reactions, including hydroamination and hydroalkoxylation, were previously catalyzed with [Ru(Cp/Cp*)(PR2NRʹ2)(MeCN)]PF6 catalysts. However, validation of the proposed mechanistic pathway for these complexes has not yet been …
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Development of Stereoselective Hydrofunctionalization Reactions Enabled by Dual Copper (I) Hydride and Palladium Catalysis
… dissertation describes several new CuH-catalyzed hydrofunctionalization reactions, particularly those which rely on dual CuH- and Pd-catalysis. Chapter one offers a synopsis on the history of CuH catalysis and the seminal discoveries in dual CuH- and Pd-catalyzed reactions. Chapter two describes …
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Sustainable catalysis using iron based catalysts for hydrofunctionalization of c=x (x = o, n) unsaturated bonds
Transition metal complexes are capable of catalyzing organic transformations with exceptional efficiency and are rightly considered as indispensable tools in organic synthesis. High catalytic activity (especially at low catalyst loadings), selectivity, and stability are some of the important …
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Gold(I) and Platinum(II)-Catalyzed Hydrofunctionalization of Allenes and Alkenes with Carbon and Nitrogen Nucleophiles
<p><p>The wide-spread occurrence of biologically active nitrogen-containing heterocycles and allylic amines inspired us to develop atom-economical methods for their syntheses.</p></p><p><p>A cationic gold(I) <italic>N</italic>-heterocyclic carbene complex catalyzed the intermolecular hydroarylation …
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I. Multicatalysis: Development of a BiOTf₃-catalyzed Nucleophilic Addition/Hydrofunctionalization Reaction in the Synthesis of Complex Heterocycles; . . .
One of the major drawbacks to traditional syntheses is the requirement for iterative synthesis, which is not only chemically inefficient and time-consuming, but environmentally unfriendly due to waste generated during purification procedures. A way to circumvent problems posed by iterative …
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Catalytic hydrofunctionalization and small molecule reactivity at a low-valent cobalt center supported by a bis(carbene) CCC pincer ligand
The ubiquity of noble metal catalysts in both industrial and academic settings is a testament to their impressive reactivity, versatility, and modularity. Recent advances in cross-coupling catalyses have principally been achieved with this privileged class of compounds, in large part due to the …
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Mechanistic Studies of pi-Activation Catalysis by Cationic Gold(I) and Brønsted-acid
… are typically invoked for gold(I)-catalyzed hydrofunctionalization and cycloisomerization processes, but direct experimental evidence for this mechanism is limited. </p><p>As an extension of the pioneering research in the Widenhoefer lab on the synthesis and characterization of gold(I) …
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Part I: Development of New Methods for Multicatalysis: Bismuth(III) Triflate-Catalyzed Hydrofunctionalizations . . .
… unite a nucleophilic addition event with the hydrofunctionalization reaction. The resulting multicatalytic methods capably effect the formation of complex heterocyclic compounds. The second chapter discloses an innovative paradigm for nucleophilic substitution involving aromatic cation …
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Supporting Well-Defined Platinum Group Metals in Metal-Organic Frameworks for Heterogeneous Catalysis
… such as cross-coupling, oligomerization, and hydrofunctionalization. Such homogeneous catalysts still find widespread application at the industrial scale, but the steep cost of these metals places stringent requirements on homogeneous systems for metal recovery. Heterogenization of PGMs thus …
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Ligand design in nickel and cobalt complexes for homogeneous catalysis
… This complex was shown to participate in hydrofunctionalization reactions in a similar fashion to (DippCCC)CoN2, catalyzing the hydroboration/silylation of olefins.
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A Radical Approach to Photochemical Transformations Using Earth-Abundant Metals
… ligands could be equally applied in an analogous hydrofunctionalization reaction manifold. Exciting, we found this to be true and further expand cooperative LMCT/HAT to achieve a photocatalytic anti-Markovnikov hydrochlorination of unsaturated hydrocarbons. Enabled by selective oxidation of …
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Metal-ligand cooperativity in first row transition metals: hydrosilylation catalysis and mechanistic insights
… promise in 1st row transition metal catalyzed hydrofunctionalization reactions. Chapter 3 describes the reactivity of a series of iron complexes containing a phosphine-imine ligand, 2-Ph2PC6H4CH=N(4-ClC6H4) (PCHNArCl). These complexes show rich redox chemistry that involve the ligand, including …
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The Development of Palladium and Cobalt-Catalyzed Methods for the Syntheses of alpha-Trifluoromethyl and Alkyl Amines
<p>The prevalence of nitrogen-containing compounds in medicinal chemistry has driven the need for the development of methodologies for the construction of chiral amines in organic synthesis. Amongst these chiral amines, a-trifluoromethyl and alkyl amines are an important subclass that have been …