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Showing 1 to 20 of 65 for “"Hydrazone"”.
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Asymmetric synthesis of lignans and of α-heteroaryl)alkylamines employing the SAMP-/RAMP-hydrazone method
… of heteroarenyllithium species to SAMP-/RAMP-hydrazones, has been developed. Moreover the novel methodology was successfully applied to the synthesis of biologically interesting compounds such as a-aminoacids and b-aminosulfones.
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MANNICH BASES DERIVED FROM STYRYL ALKYL KETONES AND THEIR HYDRAZONE ANALOGS AS POTENTIAL ALKYLATING AGENTS
… ketones and their corresponding aryl and aroyl hydrazones have been accomplished and the compounds were evaluated against P388 lymphocytic leukemia in mice. The Mannich bases derived from a series of α,ß-unsaturated ketones I mentioned above can be divided into two series namely, …
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Investigation of aryldimethylsilanolates in palladium-catalyzed cross-coupling reactions and development of chiral bis-hydrazone ligands for asymmetric aryl-aryl couplings
… synthetic route to access a number of chiral bis-hydrazone ligands featuring a 2,5-diarylpyrrolidine moiety. This endeavor enables systematic investigation of the ligand effect on the reactivity and enantioselectivity of the reaction. The origin of the chiral induction has been rationalized …
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Asymmetrische Synthese von Tarchonanthuslacton und Pironetin-Bausteinen
… in the synthesis are an unsaturated SAMP-hydrazone and an alpha,beta-unsaturated lactone. The SAMP-hydrazone was easily prepared utilizing a stereoselective alpha-alkylation of diethyl SAMP-hydrazone using crotylbromide in good yield (86%) and diastereomeric excess (92%). The other …
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Untersuchungen zur diastereo- und enantioselektiven Synthese von Matsuon und asymmetrische Synthese von anti-1,2-Sulfanylaminen
… natural product described using the SAMP- /RAMP-hydrazone method. Several chiral building blocks were synthesized in high diastereomeric and enantiomeric excesses but the title compound could not be obtained. In the second part of the thesis a flexible diastereo- and enantioselective synthesis of …
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Zur asymmetrischen Synthese von C-Azanucleosiden und 2-Amino-1,3-diolen
… approaches envisaged, using the SAMP- /RAMP-Hydrazone methodology to synthesese the desired compound are herein described. Several chiral building blocks were synthesized in high diastereomeric and enantiomeric excess however the titled compound could not be obtained. In the second part a …
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Zur asymmetrischen Synthese von Beta-Thio-Alpha-Aminosäuren
… described using chiral Amines or the SAMP-/RAMP-hydrazone methodology. Nearly all retrosynthetic approaches are starting with Bromacetaldehyde-Diethylacetale, which is nucleophil substituted with thiolates. After acidic hydrolyses of the acetals the correspending sulphur-substituted aldehydes are …
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Asymmetrische Synthese neuer planar- und zentral-chiraler Ferrocenylliganden
… ferrocenyl diketones via our SAMP/RAMP-hydrazone method. Keystep is the stepwise diastereoselective ortho-metalation of 1,1'-bisbenzoylferrocene-bis-SAMP-hydrazone followed by trapping of various types of electrophiles. Within our studies we demonstrate the broad applicability of this …
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Asymmetrische Synthese von 2-Methyl-substituierten 1,3-Diolen
… (SAMP) to the respective SAMP-hydrazone proved to be an excellent platform for general asymmetric synthesis. Consequently in 1989 we published a stereoselective a-alkylation of the respective SAMP-hydrazone followed by oxidative auxiliary cleavage to the corresponding chiral, …
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