Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"Hybrid Nanoparticles"”.
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Development of Gold-Magnetite Hybrid Nanoparticles for Advanced Radiotherapy
… functions in the same agent. Gold-magnetite hybrid nanoparticles (H-NPs) are proposed as innovative theranostic nanotools for imaging-guided radiosensitization of cancers. H-NPs are designed to exert a dual function: (i) to provide contrast enhancement in magnetic resonance imaging (MRI).and …
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Biologically Inspired Design of Protein-Silica Hybrid Nanoparticles for Drug Delivery Applications
… The overall aim of this work is to engineer a hybrid nanomaterial system comprised of protein and silica and to characterize its potential as an encapsulating drug carrier. The synthesis of silica, an attractive nanomaterial component because it is both biocompatible as well as structurally and …
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The development and evaluation of multifunctional silver iron-oxide hybrid nanoparticles towards enhanced pancreatic cancer therapy
… this issue. Multifunctional silver iron-oxide hybrid nanoparticles (AgHNPs) are presented as a thermo-responsive drug delivery system to improve pancreatic cancer therapy by reducing harsh systemic side effects of chemotherapy drugs and overcoming chemoresistance by the tumour environment and …
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Development of thermal field-flow fractionation for the characterization of hybrid nanoparticles and polymers with complex architecture
… FFF to be leveraged for not only separation of nanoparticles and polymers but also as a characterization tool to obtain physiochemical distributions. Thermal FFF is unique as the separation mechanism is based on the differential transport of analytes in the presence of a temperature gradient. …
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Design, Development and Evaluation of Erlotinib-Loaded Hybrid Nanoparticles for Targeted Drug Delivery to NonSmall Cell Lung Cancer
… erlotinib-loaded coreshell type lipid albumin hybrid nanoparticles (CSLAHNPs) for targeted drug delivery to nonsmall cell lung cancer (NSCLC). Erlotinib (ETB) is a highly selective, potent and reversible inhibitor of epidermal growth factor receptor tyrosine kinase (EGFR) which is overexpressed …
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Nanoparticles for Oil Dispersants and Nano Tracers
Nanoparticles are promising candidates to improve the efficiency of various activities in oil and gas industry such as reservoir characterization, enhanced oil recovery, and oil dispersion due to their large surface area, interfacial activity, and tunable chemical properties. In this dissertation, …
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ADVANCED POROUS MATERIALS IN MIXED MATRIX MEMBRANES FOR CARBON DIOXIDE CAPTURE
… nanosheets, MOF@covalent organic framework (COF) hybrid nanoparticles, three dimensional COF nanoparticles, have been explored as potential fillers in MMMs to further enhance the separation performance of pure polymeric membranes. These works will shed lights on the design and preparation of …
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Development of Random Triblock Copolymer Based Nanoparticulate Formulation for Sustained Release of Macromolecules/Biologics in Treatment of Posterior Segment Ocular Diseases
… order to ensure sustained and prolonged release, nanoparticles were suspended in thermosensitive gel which acted as a secondary barrier. The second approach was combining the benefit of two technologies i.e. nanoparticle and liposome to formulate hybrid nanoparticles encapsulating IgG, IgG F(ab)’₂ …
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Particle Manipulation Via Optical Forces and Engineering Soft-Matter Systems With Tunable Nonlinearities.
… purely dielectric as well as metallic and hybrid nanoparticles. In particular, we find that plasmonic resonances allow for extremely high and spectrally tunable polarizabilities, leading to unique nonlinear light-matter interactions. Here, for the first time we were able to observe …
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Singlet Oxygen Production and Its Kinetics in Nanoparticle-Photosensitizer Hybrid Systems
… from several common types of colloidal hybrid nanoparticle-photosensitizer materials. Silica- and liposome-based photosensitizing nanoparticles were employed to quantify singlet oxygen partition between the various local microenvironments inherent to each formulation, which fundamentally …
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Multifunctional Hybrid Theranostic Nanoplatforms for Cancer Imaging and Therapy
… challenges, such as off-targeting toxicity of nanoparticles, poor tumor accumulation, size, aggregation-imposed vascular confinement, and complex designs for combining imaging and therapeutic agents. To address these issues, this dissertation explores the design, synthesis, characterization, …
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Hybrids Based on Layered Silicates
Novel hybrid nanoparticles were synthesized based on combinations of various layered silicates as inorganic core and well-defined polymer chains as a shell. In all cases positively charged 2-(dimethylamino)ethyl methacrylate (DMAEMA) was incorporated into the polymeric structure to serve as a firm …
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Development of nanoparticle based nicotine vaccines for smoking cessation
… lipid- poly(lactic-co-glycolic acid) (PLGA) hybrid NPs were constructed as vaccine delivery system. due to the fact that nanohorn is not currently approved for clinical use, we substituted the nanohorn with poly(lactic-co-glycolic acid) (PLGA) nanoparticles and constructed PLGA-lipid hybrid …
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Design, Synthesis and Application of Cylindrical Polymer Brushes: From Nanostructures to Advanced Materials
… of novel one-dimensional (1D) organic/inorganic hybrid nanostructures. The ‘grafting-from’ approach was chosen as the general method to synthesize well-defined CPBs with various chemical and structural compositions. The linear polymer backbones (polyinitiators) were obtained by anionic …
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Dual-Responsive Polymer and Hybrid Systems: Applications for Gene Delivery and Hydrogels
… with the magnetic properties of iron oxide nanoparticles to enable an activity of the gene vector in an applied external magnetic field. Another point was to apply the dual-responsive behavior of PDMAEMA (temperature and pH) for physically cross-linked hydrogels. Initial studies on magnetic …