Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 2 of 2 for “"Hybrid Drugs"”.
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In silico-guided design, synthesis and antimicrobial activity of piperazine-linked 8-hydroxyquinoline-isatin hybrids
… for the discovery of new antimicrobial agents. Hybrid drugs formed by covalently binding two pharmacophores, have shown promise in combating resistance. Monomers selected for this study include 8-hydroxyquinoline and isatin. There exist reports on the versatility of the 8-hydroxyquinoline ring …
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Pleuromutilin and its Application Towards Bidentate Antibiotics: Triazoles, Linker Chemistry, and Serendipitous Discoveries
… antibiotics, as well as two FDA approved drugs, retapamulin and lefamulin. This class exhibits a low propensity to resistance development. This dissertation reports progress in rational design, synthesis, and testing of pleuromutilin derived antibiotics. Among these new classes of …