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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 155 for “"Hyaluronic acid"”.
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hyaluronic acid networks in wound healing
… that synthesize key ECM components, namely hyaluronic acid (HA) and associated proteins. In digits, these ECM networks were upregulated in regeneration, and their knockdown markedly impaired healing and enhanced deposition of collagen. Atomic force microscopy revealed that HA networks are …
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Injectable hyaluronic acid scaffolds for cartilage tissue engineering
Every year tens of millions worldwide suffer from cartilage damage, caused by mechanical degradation, trauma or disease. Because of the lack of blood supply and low cell concentration within the tissue, cartilage has very limited regenerative ability. Although current treatments can provide …
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Crosslinked Hyaluronic Acid Hydrogel Networks Designed as Mechanical Actuators
… designed, fabricated, and characterized a novel hyaluronic acid based hydrogel that shrinks over time along a pre-defined axis thereby providing the source for tension that could be used for sustained axonal stretch growth. The shear thinning property of hyaluronic acid (HA) enabled us to test if …
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MOLECULAR ANALYSIS OF HYALURONIC ACID (HA) USING SOLID-STATE NANOPORES
Hyaluronic acid (HA; hyaluronan) has emerged as a powerful indicator for a range of diseases and physiological conditions, including cancer, osteoarthritis, and wound healing after injury. Evidence has shown that low molecular weight HA is pro-inflammatory while high molecular weight HA is …
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3D printing of hyaluronic acid scaffolds for tissue engineering applications
… fabricate 3D microperiodic scaffolds composed of hyaluronic acid (HA), a natural, biocompatible, biodegradeable polymer, for cell culture and tissue engineering applications. HA is functionalized with UV-curable glycidyl methacrylate (GM) and printed to create 3D scaffolds with filament diameters …
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Collagen and hyaluronic acid interpenetrating polymer networks for tissue engineering
… In this thesis, collagen and methacrylated hyaluronic acid are combined in IPNs to produce a range of new biocompatible. The fabrication method allows for control of compressive strength of the IPN hydrogels. The materials are confirmed to be homogeneous at microscopic scales with …
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Hyaluronic acid enhancement of expanded polytetrafluoroethylene for small diameter vascular grafts
… and characterize ePTFE grafts prepared with hyaluronic acid (HA), evaluate thrombogenic potential of ePTFE-HA grafts, and evaluate graft mechanical properties and coating durability. The results in this work indicate the successful production of ePTFE-HA materials using a solvent infiltration …
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Development and Characterization of Photocrosslinkable Hyaluronic Acid Hydrogels for Cartilage Regeneration
… the development and use of photopolymerizable hyaluronic acid (HA) based hydrogels for TE to optimize cellular interactions and neocartilage formation. By altering hydrogel design parameters (e.g., molecular weight and macromer concentration), a wide range of hydrogel properties were obtained. …
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The effects of hyaluronic acid and exercise on equine skeletal muscle
Unaccustomed, strenuous exercise can cause skeletal muscle damage that subsequently induces an acute inflammatory response in the tissue which is marked by an infiltration of leukocytes into the damaged muscle. To try and suppress the initial pro-inflammatory response in skeletal muscle of horses …
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Cd44-Hyaluronic Acid Interactions in Il-2 Induced Vascular Leak Syndrome
… we tested whether use of mAbs against CD44 or hyaluronic acid (HA), the ligand for CD44, can abrogate IL-2 induced VLS. Administration of IL-2 (75,000 U/mouse, three times a day for 4 days) into C57BL/6 mice triggered significant VLS in the lungs and liver. Interestingly, HA caused a marked …
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Optimization and Translation of MSC-Based Hyaluronic Acid Hydrogels for Cartilage Repair
… the potential of a photo-polymerizable hyaluronic acid (HA) hydrogel to promote MSC chondrogenesis and improved construct maturation by optimizing macromer and MSC seeding density. The beneficial effects of dynamic compressive loading, high MSC density, and continuous mixing (orbital …
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Bioproduction Optimization and Characterization of Hyaluronic Acid in Escherichia coli and Nicotiana benthamiana
Hyaluronic Acid (HA) is a polymer widely used in biomedical and pharmaceutical applications, with its biological and physical properties strongly dependent on molecular weight. Conventional production methods, including animal tissue extraction and Streptococcus fermentation, yield high-molecular …
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Dermal delivery of Centella asiatica using hyaluronic acid niosomal system for wound healing
… wound healing. Asiaticoside (ASC) and asiatic acid (AA) are natural bioactive compounds from Centella asiatica. Many effects of these two compounds, including promoting fibroblast proliferation, increased epithelial cell migration, and new capillary formation, has been reported. Their efficacy …
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Preparation, Characterization and In Vitro Evaluation of Metformin Loaded Hyaluronic Acid Nanoparticles for Oral Delivery
… containing metformin with a mucoadhesive polymer hyaluronic acid. Blank and drug loaded nanoparticles were prepared using hyaluronic acid polymer by precipitation method with a high entrapment efficiency. The average particle size of the blank and drug loaded nanoparticles was found to be 155.52 …
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DEVELOPMENT AND APPLICATION OF MODIFIED HYALURONIC ACID DERIVED NANOPARTICLES FOR IMAGE GUIDED SURGERY AND DRUG DELIVERY
… using the natural carbohydrate glycosaminoglycan hyaluronic acid (HLA) as a hydrophilic polymer backbone for the synthesis of nanoscale polymeric micelles loaded with either the near infrared (NIR) fluorophore indocyanine green (ICG) for image guided surgery (IGS), or the fatty acid synthase …
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Sustained Release of Growth Factors from Hyaluronic Acid Hydrogels and Polyethylene-Glycol Microparticles for Axonal Growth
… we explored the feasibility of using injectable hyaluronic acid (HA) hydrogels and polyethylene glycol-diacrylate (PEG-DA) microparticles as platforms for sustained delivery of bioactive NT-3 and IGF-1, respectively. HA hydrogels were successfully synthesized using a polyethylene-glycol (PEG) …
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Development and biophysical characterization of a hyaluronic acid – vitamin E conjugate as a subcutaneous delivery platform
… protein therapeutics delivered subcutaneously. Hyaluronic acid, a ubiquitous polysaccharide of the extracellular matrix often used in drug delivery applications, was hydrophobically functionalized by the addition of glycine-modified vitamin E (-tocopherol) to form a self-assembling nanogel …
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