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Showing 1 to 16 of 16 for “"Hyaluronate"”.
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Hyaluronate Lyase Gene of <i>Streptococcus pyogenes</i>: Molecular Characterization and Regulation
… of causing tissue damage; one of which is a hyaluronate lyase. Little information is available regarding the regulation of streptococcal hyaluronidase. As such, the expression of <em>hyl</em>A in the hyaluronate lyase-producing strain ATCC 10403 and in strains that do not produce detectable …
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Serotype Association and Regulation of the Hyaluronate Lyase Gene of <i>Streptococcus pyogenes</i>
… by a complex regulatory network. These include hyaluronate lyase, an enzyme that degrades hyaluronic acid, a major component of the human extracellular matrix. Paradoxically, hyaluronic acid is also the sole component of the bacterium's capsule, a primary defense against the host immune …
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Effects of sodium hyaluronate and triamcinolone acetonide on proteoglycan metabolism in equine articular chondrocytes treated with interleukin-1
… if the effects of a high molecular weight sodium hyaluronate (HA) alone or in combination with triamcinolone acetate (TA) can mitigate chondrocyte proteoglycan catabolism caused by interleukin-1 (IL-1) administration. Chondrocytes were collected from fetlock joints of ten horses euthanized for …
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Modulation of TGF-beta and extracellular matrix in retionic acid-induced cleft palate
… III, and IV, fibronectin, tenascin, laminin and hyaluronate were investigated in normal palate development. Collagen I and collagen IV, laminin, and hyaluronate proved to have spatial-temporal patterns of localization during palatal shelf growth and reorientation. However, using …
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Structure and conformations of heteropolysaccharides
… Various solid state conformations adopted by hyaluronate have been studied by Xray diffraction techniques. A four-fold helical structure having a fibre repeat of 3.39 nm is the more readily obtained form. Initial computer model building studies showed that a double helical structure was one …
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Liver Fibrosis in Chronic Hepatitis C Virus Infection: Diagnosis, Dynamics, And Clinical Significance // Чернодробна фиброза при хроничната хепатит C-вирусна инфекция:диагностика, динамика и клинично значение
… fibrosis, including examination of serum hyaluronate levels. Five risk factors for bridging fibrosis were defined: age at infection of 35 years; disease duration of 15 years; overweight; significant alcohol consumption; and transfusion route of infection. Fibrosis regression was observed …
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The effects of hyaluronic acid and exercise on equine skeletal muscle
… single exercise stress test, a commercial sodium hyaluronate (HA) treatment was administered and tested for anti-inflammatory properties. Unfit, adult Thoroughbreds were intravenously injected three times with HA or received no injection at all (CON) over a 3-week period before performing a single …
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Role of CD44, Fas Ligand, and Perforin in the Cytotoxicity Mediated by Natural Killer Cells
… lysis of endothelial cells through its ligand, hyaluronate. Upregulation of perforin and FasL in activated NK/LAK cells may explain why such cells can kill a wide variety of tumor cells efficiently. On the other hand, activated NK/LAK cells express increase increased levels of CD44 and use this …
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Comparison of wettability for surface of ocular prosthesis depending on different kind of artificial tear eye drops
… artificial tear eye drops that contain sodium hyaluronate (HA) 0.1%, 0.18%, 0.3%, carboxyl methylcellulose sodium (CMC), hydroxymethylcelluose+dextran (HMC), propylene glycol+polyethylene glycol (PG), polysorbate 80 (PS), povidone (Pov) have been studied. According to the conventional methods …
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Effect of homozygous lpr and gld mutations on the immune functions and induction of autoimmunity
… lysis of endothelial cells and that CD44-hyaluronate interactions were important for endothelial cell lysis. Thus, interactions between DN T cells and endothelial cells <i>in vivo</i> may trigger an inflammatory response and contribute to the vasculitis seen in <i>lpr</i> and <i>gld</i> …
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The use of nanotechnology in enhancing the efficacy of cosmetic actives of natural origin
… dosage form was developed by adding sodium hyaluronate (HA) to a dispersion of purified TA-LNC. Rheological study of obtained HA hydrogels showed an increase in both elastic (G') and viscous (Gil) moduli and a decrease in the crossover frequencies, which indicated that the addition of TA-LNC …
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Role of CD44 in Immune Functions and Endothelial Cell Injury
In addition to the antigen-specific receptors, the T and B cells also express a variety of adhesion molecules, which are known to participate in cell-cell interaction, migration, homing and signal transduction. CD44 is a widely distributed cell surface glycoprotein whose principal ligand has been …
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Cd44-Hyaluronic Acid Interactions in Il-2 Induced Vascular Leak Syndrome
Immunotherapy with IL-2 is accompanied by severe toxicity leading to development of vascular leak syndrome (VLS). Previous studies from our laboratory demonstrated that CD44 knockout mice exhibit marked decrease in IL-2 induced VLS, thereby suggesting a role for CD44 in VLS. In the current study we …
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DIFFERENTIATION OF NEURAL STEM CELL USING SMALL MOLECULES IN 2D AND 3D CULTURE SYSTEM
The neuronal differentiation of neural stem cells (NSCs) has received much attention due to its potential for the treatment of neurodegenerative diseases (i.e., Parkinson’s and Alzheimer’s diseases). In this regard, discovering compounds that direct differentiation of NSCs is highly required to …
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Studies of the interaction of hepatitis B virus with human haemopoietic cells.
… to leucocyte pM only. Chondroitin sulphate A and hyaluronate had no effect on binding to either PM, arguing that simple electrostatic properties of GAGs were not responsible for the observed effecrs. The incomplete inhibition by HE and enhancement by CS-C could indicate the presence of more than …