Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 9 of 9 for “"Hv1"”.
-
Engineering Hv1 Channel Mutations and Targeted Drug for Treatment of Hv1 Mutation Associated with Cancer
The voltage-gated proton channel Hv1 is crucial for maintaining cellular pH homeostasis by regulating proton movement across membranes, playing a vital role in acid extrusion and intracellular pH regulation. Dysregulation of Hv1 is associated with various diseases, including cancer, where it helps …
-
Hv1 novel peptide inhibitor extracted from tarantula venom
… rosea, and human voltage-gated proton (Hv1) channels, critical in pH regulation and cellular signaling. Utilizing patch clamp techniques on genetically modified Chinese Hamster Ovary cells expressing human Hv1, the study revealed that GsAF-I significantly stabilizes the closed state of …
-
The HV1 proton channel of Lingulodinium polyedrum localizes to the bioluminescent scintillon
<p>In 1972, J. Woodland Hastings and colleagues predicted the existence of a proton selective channel that opens in response to depolarizing voltage (H<sub>V</sub>1) across the vacuole membrane of bioluminescent dinoflagellates and conducts protons into specialized luminescence compartments …
-
Voltage Sensing Mechanism in the Voltage-gated and Proton (H+)-selective Ion Channel Hv1
… aqueous water-wire proton conductance (GAQ) in Hv1 channels is controlled by changes in membrane potential and the transmembrane pH gradient (ΔpH). The mechanism by which changes in ΔpH affect the apparent voltage dependence of GAQ activation is not understood. In order to measure voltage sensor …
-
I) Hv1, LBP and LCF reconstitution in Liposomes II) Signed, Sealed, and Delivered: CPP Technology Delivers Active Protein Cargo
… Luciferase (LCF), voltage-gated proton channel (Hv1), as well as the substrate Luciferin (LH<sub>2</sub>). Bioluminescence is triggered by an internal drop in pH of the scintillon initiated by the voltage activation of Hv1 in the membrane. The first focus of this study is to use a synthetic …
-
Sequence Detection and Comparative Analysis of the Hv1 and Hv2 Control Regions of Human Mitochondrial DNA by Denaturing High-Performance Liquid Chromatography
<p>The objective of this research was the evaluation and forensic validation of Denaturing High-Performance Liquid Chromatography (DHPLC) as a sequencingindependent means of detecting the presence of sequence differences in pair-wise mixtures of non-concordant amplicons of human mitochondrial DNA …
-
Forensische DNA-Analytik
… beiden nichtcodierenden hypervariablen Regionen HV1 und HV2 wurden durch Sequenzierung erschlossen und ergaben zusammen für eine deutsche Populationsstichprobe (Unterfranken, n = 180) einen Diskriminationsindex (DI) von 0,99. Der DI betrug bei alleiniger Betrachtung der HV1 für eine deutsche (n = …
-
Genetic and biochemical analysis of materials from a medieval population from Ynys Mon North Wales
… using several primers specific for human HV1 & 2 mtDNA targets was also met with limited success. The results show that 14.8% of the skeletal teeth samples were amplified, and these were not commonly reproducible. DNA spiking trials demonstrated that some of the samples were affected by …
-
Compositional Exploration and Microstructural- Environmental Evaluation of Alloys for Glass Vitrification Applications
… cooling and contributed to high hardness (≥575 HV1). Oxidation testing at 1000°C confirmed improved resistance with increasing Cr content, with the Fe-21Cr-24Si alloy exhibiting a parabolic rate constant ~33% lower than that of the best-performing Co-101 derivative. This work establishes …