Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 34 for “"Humoral immune responses"”.
-
Innate and humoral immune responses to HIV-1
Understanding cellular and humoral immune responses to HIV-1 infection and designed HIV immunogens are imperative to the development of an effective anti-HIV vaccine. In this thesis we investigate aspects of both the cellular innate and adaptive humoral arms of the immune system in response to …
-
The role of DEAD-box helicase 1 in humoral immune responses
A key characteristic of humoral immune responses is the ability of B-cells to recognise an endless array of antigens through their immunoglobulin (Ig) genes and secret these as soluble antibodies to help combat invading pathogens. Primary diversification occurs through VDJ recombination during …
-
Characterizing Peripheral Cellular and Humoral Immune Responses to Haemonchus contortus in Sheep
… have utilized a true parasite naive animal for immune characterization. In this study, development of peripheral immune response was characterized in parasite resistant St. Croix lambs and parasite susceptible Suffolk crossbred Lambs. Lambs were separated into three treatment groups: naive, …
-
An analysis of the cellular and humoral immune responses of Galleria mellonella larvae
The invertebrate immune system is composed of the intertwined cellular and humoral components which have similar structural and functional attributes to the mammalian innate immune system. For this reason insects have served as useful screening tools in academic and industry research for the …
-
Understanding the interplay between HIV-1 diversity, humoral immune responses and viral fitness
… (ADCC) and neutralizing antibody (nAb) responses are both thought to be important responses to elicit through vaccination. This thesis characterises neutralizing response in two cohorts in Africa, and in a detailed study of one individual, elucidates the interplay between ADCC and nAb …
-
An alum particle-based platform to enhance and investigate humoral immune responses to immunization
… delivery of vaccines has been shown to amplify humoral immune responses compared to traditional bolus immunization, but clinical translation of frequent repeated immunizations is challenging. In this thesis, we investigate the use of peptide linkers containing consecutive phosphoserine residues …
-
Induction of anti-ergotamine antibodies in mice and steers and protection against fescue toxicosis in mice
… Hyperprolactinemia decreases cell-mediated and humoral immune responses in mice. Therefore, steers grazing EI or endophyte-free (EF) fescue forages were vaccinated to assess humoral immune responses. Steers grazing EI fescue exhibited classical clinical signs of fescue toxicosis, and mounted …
-
Elucidation of antigenic epitopes on the rubella virus E1 glycoprotein
… in humans were examined for both cellular and humoral immune responses. It was found that of the structural proteins, El glycoprotein was the dominant antigen recognized by the study population sampled from normal individuals with no history of rubella associated conditions. It was also found …
-
Lipid-coated micro- and nanoparticles as a biomimetic vaccine delivery platform
… the ability of this system to potentiate humoral immune responses against recombinant protein vaccines, using ovalbumin as a model antigen. In studies of both cellular and humoral immune responses, we found that lipid-coated microparticles co-displaying protein and lipophilic adjuvant …
-
Immune Responses and Hematologic Alterations in Splenectomized Pigs Experimentally Infected With Eperythrozoon Suis: I. A Possible Animal Model for Cold Agglutinin Disease in Man
The immune responses and hematologic alterations of acute porcine eperythrozoonosis were studied in 2-month to 4-month-old splenectomized crossbred sibling pigs. The clinical course of the disease was monitored by complete blood counts and serum chemical determinations. Cell-mediated immune …
-
Optimization of chimaeric HIV-1 virus-like particle (VLP) production and immunogenicity testing of VLPs in mice
… that are able to elicit effective cellular and humoral immune responses, both of which are believed to be important in the eradication of the virus. One such approach is the use of HIV-1 Gag VLPs as vaccine candidates. In this study, the production of two chimaeric (Gag VLP vaccine candidates …
-
Regulation of Antimicrobial Peptide Genes in Insects by the Toll Pathway and NF-kB Transcription Factors
… bacteria, fungi and viruses, and the Immune Deficiency (IMD) pathway, which provides protection against Gram-negative bacteria. Insect innate immune responses can be categorized broadly into two types: cellular and humoral. The cellular responses include insect blood cells known as …
-
Assessment of the Expression of Brucella Abortus Heat Shock Protein, Groel, in Vaccinia Virus to Induce Protection Against a Brucella Challenge in Balb/C Mice
… control vaccines. Mice were bled and their humoral immune responses assessed. In addition, mice were challenged with virulent B. abortus strain 2308 and protection measured by the rate of splenic clearance of live Brucella. In spite of demonstrating specific GroEL antibodies in recombinant …
-
RNA transmission and expression from inert HIV candidate vaccine virus-like-particles
… are potent stimulators of both cellular and humoral immune responses in animal models. The encapsidation of large concentrations of random cellular RNA species is known to accompany the assembly of HIV virus particles. This RNA plays a crucial role by serving as a molecular scaffold for the …
-
Immunosenescence in B Cells: A Study on Changes in Immunoregulator Expression and Metabolism With Age
… (ASCs) in mice and humans. In humans, I measured humoral immune responses to the trivalent inactivated influenza vaccine (TIV) during the 2011-12 and 2012-13 influenza seasons. ASCs in the aged were observed to have decreased expression of the defining markers CD27 and CD38. Aged ASCs also …
-
Profiling B cell immune responses by microengraving
The ability to monitor an immune response in the course of vaccination or disease progression is highly desirable. Currently, no technique is able to generate a comprehensive profile of the individual cells involved and the antibodies they produce at a particular point during the immune response. …
-
Yellow Fever: Role of Heterologous Flavivirus Immunity on Urban Emergence
… appears to be mediated mainly by humoral immune responses. These studies underscore the importance to re-assess the risk of YF outbreak accounting for prior immunity from flaviviruses that are endemic.
-
Development and Characterization of A Recombinant Orf Virus Vector Expressing the Spike Protein of Porcine Epidemic Diarrhea Virus
… proteins (IMPs) that evade and/or modulate host immune responses to infection and contribute to virus virulence and disease pathogenesis. Given biological properties and unique immunomodula tor y properties, ORFV has gained significant attention in recent years for its potential as a vaccine …
-
Age-Dependency of Swine Antibody-Dependent Cellular Cytotoxicity Against Pseudorabies Virus-Infected Cells
… PRV infections involves both cellular and humoral immune responses. Antibody-dependent cellular cytotoxicity (ADCC) which involves both cell functions and antibodies might prove to be important in protection against PRV. Therefore, the age differences and age development of ADCC in pigs …
-
Development of plant-produced Bluetongue virus vaccines
… in order to analyse their ability to elicit humoral immune responses.
Page 1 of 2