Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 29 for “"Humoral Responses"”.
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Early-life immunity and susceptibility to Mycobacteria
… and mortality in children. Infant immune responses to these pathogens, whether during standalone infection, co-infection or resulting from maternal infection are not fully understood. To contribute to this knowledge gap, we investigated early-life immune responses, how they relate to …
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Investigating the Effect of Antibody-Mediated Feedback on Ongoing Germinal Center Responses
… antibodies can influence the outcome of future humoral responses; however, whether antibody from an ongoing response can feedback onto contemporaneous GCs to influence B cell clonal selection and affinity maturation in real-time remains poorly understood. Here we present a genetic mouse tool to …
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Pigeon breeder's disease: the clinical spectrum and humoral response; an investigation of the nature and extent of extrinsic allergic alveolitis due to pigeon-derived antigens among pigeon fanciers continuing to pursue the pastime, with particular reference to early clinical and humoral-mediated responses following exposure
… among active pigeon fanciers, and the associated humoral responses to pigeon -derived antigens. Clinical data was obtained in questionnaire format from a large scale field study interviewing 100 pigeon fanciers. A wide range of skin tests were performed and serum antibodies were estimated by …
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The expression and regulation on antimicrobial peptide genes in insects: studies in the tobacco hornworm manduca sexta
… and the silkworm Bombyx mori. One of the insect humoral responses is the induced production of antimicrobial peptides (AMPs). In D. melanogaster, bacterial peptidoglycan (PG) and fungal beta-1,3-glucan can induce AMP production by activating the Toll and the IMD (immune deficiency) pathway. …
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The role of Fyn and B-cell expressed ADAM10 in early B cell development, germinal center formation and terminal B cell differentiation
… post-switch cells leads to severe impairments in humoral responses. When ADAM10 was deleted from all peripheral B cells a decrease in antigen specific IgG production was seen both with respect to serum levels and IgG ASCs, indicating that plasma cell (PC) differentiation is influenced. Cells …
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Engineered microneedles for transcutaneous vaccine delivery
… able to elicit strong functional CD8' T cell and humoral responses matching or exceeding the potency of in vivo electroporation, currently the most promising approach for clinical DNA delivery in humans. Further efforts have explored the use of LbL for encapsulation and delivery of soluble and …
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Profiling B cell immune responses by microengraving
… a better understanding of the dynamics of immune responses. currently available methods for profiling of B cells that produce antigen-specific antibodies helped clarify humoral responses, but it remains a challenge to generate measurements capable of detailing the phenotypic changes and secretion …
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The Development and Assessment of Immune Responses in Plasmid DNA, VSV-Vectored, and Virus-Like Particle HIV Vaccinations in Murine Models
… the mechanisms by which these vaccines elicit humoral and cellular immune responses in mice by assessing antibody levels in sera and evaluating the phenotypes and functions of memory cell development in immunized mice. My results suggest that both VLP and VSV-vectored HIV vaccinations robustly …
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Evaluation of a gold nanoparticle platform as highly immunogenic and protective therapy against Burkholderia mallei, B. pseudomallei, and Enterohemorrhagic Escherichia coli O157:H7
… Also, we have shown that antigen-specific humoral responses play a significant role in the protection induced by various AuNP-coupled glycoconjugate formulations. Similarly, we have shown a protective effect of AuNP-coupled proteins in a colonization model of Enterohemorrhagic Escherichia …
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Investigating The Possible Role Of Regulatory T Cells In Suppressing DTwP And Measles-Vaccine Induced Responses In 9 Month-Old Gambian Infants
… and skewed towards Th2 and immunoregulatory responses. This results in high susceptibility to infections and impaired responses to vaccines. Regulatory T cells (Tregs) control pro-inflammatory responses and are therefore important in maintaining a fine balance of immune responses during …
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Identifying and Characterizing Transition Cells in Developmental Processes from scRNA-Seq Data
… ductal adenocarcinoma) mouse model and humoral responses against SARS-CoV-2 vaccines. By identifying transition cells in pancreatic preinvasive lesions, we observe tumor heterogeneity and can predict distinct cell fate even at early stages of tumorigenesis. Additionally, characterizing …
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Development of plasmid dna formulations for application as microspheric dna vaccines
… allowing the design and elicitation of immune responses more adequate for a wider range of pathogens. The formulation of these vaccines into the desired dosage forms extends their capability in terms of stability, routes of administration and efficacy. This thesis describes an investigation …
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Nterleukin-4 responsive dendritic, macrophage/neutrophil cells are dispensable for host resistance against Leishmania Mexicana infection in mice
… phenotype was evaluated by investigating both humoral and cellular immune responses. Mouse strains had similar footpad lesion progression, parasite loads, humoral responses, expansion of CD4+ and CD8+ T cells, their activation, memory phenotypes, and infiltration of DCs, macrophages, and …
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Immunological responses of fishes to glochidia of freshwater mussels
… host and non-host species expressed a specific humoral response to glochidial antigens after being artificially infested with the parasites. Further microagglutination tests were completed to compare titers of host and non-host fishes which were either uninfested, infested, or reinfested with …
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POST-EXPOSURE TREATMENT OF MARBURG VIRUS ANGOLA DISEASE IN NON-HUMAN PRIMATES USING RECOMBINANT VESICULAR STOMATITIS VIRUS VECTORS
… we performed RNA sequencing and flow cytometry. Humoral responses were assessed via enzyme-linked immunosorbent assays and plaque-reduction neutralization tests. In survivors, we found upregulation of STAT4, an early transcription factor associated with T helper 1 (Th1) and T follicular helper …
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The rational structure-based design of a protein nanoparticle presenting a chimeric MenB antigen
… presentation of the NadA3-PorA enhanced the humoral responses raised against the subunit antigen.;Different adjuvant systems to deliver the NadA3-PorA-Ferritin were also examined, demonstrating that an in-house, cationic liposome formulation produced by benchtop microfluidics generated a …
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Enhancement of HIV vaccine efficacy via lipid nanoparticle-based adjuvants
… vehicles which enhance immune responses to vaccines. The lack of progress in the development of an HIV humoral vaccine is due, in part, to the absence of available adjuvants which can be sufficiently potent with minimal adverse side effects. The main goal of this thesis was to …
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Expression of Bacillus Anthracis Protective Antigen in Vaccine Strain Brucella Abortus Rb51
… intracellular pathogens, cell mediated immune responses (CMI) are crucial in affording protection against brucellosis. B. abortus strain RB51 has been shown to be useful in eliciting protective cell mediated immunity and humoral responses against Brucella in cattle and other animal species. …
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Regulation of Protective B cell Anti-Tumor Responses
… plays an important role in the adaptive humoral response against tumors expressing tumor associated carbohydrate antigens (TACAs). B-1b cells specifically contribute to the antibody response to the TACA, Tn. TACAs are normally masked on healthy cells, which make these carbohydrate …
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B cell memory in STAT3 Hyper-IgE Syndrome: Cytokine integration, IgE regulation, and the architecture of human memory B cell subsets
Deleterious allergen-specific IgE responses cause lifelong and life-threatening allergic disease. However, the cellular reservoir of IgE memory in humans is incompletely characterised and prior studies have been unable to reproducibly detect human IgE+ memory B cells (MBCs). Individuals with Inborn …
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