Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"Humanin"”.
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Examining the binding of humanin and acetylcholinesterase with amyloid beta
… dysfunctional assemblies are largely obscure. Humanin (HN), a binding partner of Aβ protects against its deleterious effects while acetylcholinesterase (AChE) bound to Aβ peptide, increases aggregation and cytotoxicity of Aβ fibrils. Here, we set out to examine factors that regulate the …
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Deciphering the mechanism by which humanin binding to IGFBP3 inhibits neuronal cell death in alzheimer’s disease
… disease (AD). The neuroprotective peptide humanin (HN) counteracts this IGFBP3-induced cell death. Unfortunately, the natural synthesis of this peptide decreases with age coincident with the time that people are likely to develop AD. In addition, the precise mechanism of action of HN is …
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Novel Protective Agents against Cerebral Ischemia/Reperfusion Injury.
… mechanisms of two novel agents Gly<sup>14</sup> humanin (HNG) and necrostatin-1 (Nec-1) were examined. HNG, a highly potent neuropeptide against amyloid toxicity, exhibited anti-apoptotic properties on cerebral ischemia injury. HNG reduced infarct volume after ischemia/reperfusion injury with …