Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"Human tumour cells"”.
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Zinc Finger Protein 36L1 (ZFP36L1): Gene Expression, Regulation and Interactions with Immune Receptors in Human Tumour Cells.
… in lymphocyte activation, haematopoiesis and tumour metastasis. In this study we also report data on the detection and quantification of ZFP36L1 in several tumour cell lines such as THP1, Jurkat, B16, MCF7, and MC38. To study the function of ZFP36L1 a CRISPR-Cas9 system was used to generate …
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The desmoplastic response : mechanisms of tumour-induced fibrogenesis
… understood. To study the process, I used a human malignant melanoma cell line (UCT-Mel 7) that was established in this laboratory and that, when injected into athymic mice, gave rise to tumours that showed a number of interesting features. Firstly, the tumour induced a marked desmoplastic …
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Synthesis of bespoke matrices to investigate a novel anti-tumour molecular target using affinity chromatography. The design, synthesis and evaluation of biotinylated biarylheterocycles used as novel affinity probes in the identification of anti-tumour molecular targets.
… (IC50 16¿640 nM) against a number of human tumour cell lines. Notably, this biological activity was independent of duplex DNA binding affinity. The compounds were tested in the NCI 60-cell line panel and COMPARE analysis suggests they have a novel mechanism of action, targeting the …
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Development of a gene therapy approach for the treatment of human mammary carcinoma using tissue specific retroviral vectors
… In order to specifically target malignant cells while at the same time sparing normal tissue, cancer gene therapy will need to combine highly selective delivery with highly specific gene expression, specific gene product activity and, possibly, specific drug activation. Use of cell type or …