Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"Human prostate cancer cell"”.
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The effects of jasmonates on the proliferation of human prostate cancer cell lines in culture
… these compounds function as activators of cellular responses to diverse situations including cell death. Proliferation and cytotoxicity assays showed that the jasmonates inhibited the proliferation of the prostate cancer cell lines (PC-3 and DU-145), cultured in vitro. In addition, the type …
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CHANGES IN SUSCEPTIBILITY TO VESICULAR STOMATITIS VIRUS DURING PROGRESSION OF PROSTATE CANCER
… virus. Differing sensitivity to VSV oncolysis of human prostate cancer cell lines has been observed in previous experiments. The goal of my experiments was to determine the mechanisms of sensitivity and resistance to VSV.
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QUB-1957: a bioactive peptide from the frog skin secretion of Hylarana latouchii
… exhibits no significant effect against PC3 (human prostate cancer cell line), NCI-H157 (human non-small cell lung cancer cell line), MCF-7 (human breast cancer cell line) and U251MG (human neuronal glioblastoma cell line). These characteristics of QUB-1957 indicate that QUB-1957 is a …
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Nanomaterials for the detection of cancer-associated biomarkers
Prostate cancer persists as a major public health issue in the United States and remains the second leading cause of cancer death in men. Early detection and disease monitoring in prostate cancer can significantly improve a patient's prognosis. The advent of prostate-specific antigen (PSA) …
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The Discovery and Functional Evaluation of a Novel Bioactive Peptide, QUB-3411, from the Frog Skin Secretion of Hylarana guentheri
… of 2 µM. QUB-3411 showed better potency against human non-small cell lung cancer cell line (NCI-H157) than the human glioblastoma cell line (U251MG) and the human prostate cancer cell line (PC-3) with half inhibitory concentrations of 2.702 µM, 11.01 µM and 8.739 µM respectively, indicating …
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Effect of broccoli bioactives on prostate cancer cell invasion in vitro
… shown that broccoli bioactives may have anti-cancer activity. In this work, we hypothesized that broccoli bioactive components inhibit invasion of human prostate cancer cell line, DU145, in an in vitro model system. DU145 cells were plated into Matrigel invasion chambers placed in 24-well …
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“Differential regulation of PTHrP gene expression by 1,25(OH)2D3 in prostate cancer cell lines”
… hormone-related protein (PTHrP) is expressed by prostate cancer cells. Since PTHrP enhances the growth and osteolytic potential of prostate cancer cells, it is important to control PTHrP expression in these cells. 1,25-Dihydroxyvitamin D3 (1,25(OH)2D3) downregulates PTHrP expression in a variety …
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The Production and Characterization of a Monoclonal Antibody to a Naturally Occurring Aminomalonic Acid Epitope and a Comparison with an Antibody to a Synthetically Derived Aminomalonic Acid Epitope
… of tumor metastasis in general and prostatic cancer metastasis in particular. The problem that this addresses is the growing number of cases of prostatic cancer in the increasingly aging male population. This cancer is not lethal unless it metastasizes, yet there is no cure for the metastatic …
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Role of the extracellular matrix-integrin interaction in enzalutamide resistance of bone metastatic castration-resistant prostate cancer
Bone metastatic castration-resistant prostate cancer (bone mCRPC) is the most prevalent type of prostate cancer metastasis, accounting for 90% of all metastasis incidence. Its resistance to androgen-deprivation therapy (ADT). Enzalutamide (Enz) is a second-generation androgen-receptor (AR) …
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Suppression of Carcinogenesis and Tumor Progression by an Energy Restriction-Mimetic Agent in Murine Models of Prostate Cancer
Cancer cells preferentially utilize glycolysis to generate energy even in the presence of sufficient oxygen for oxidative phosphorylation. This shift in energy metabolism, termed the Warburg effect, is responsible for cancer cells’ high metabolic rate. Therapies that inhibit cancer cell energy …
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Testing Whether MRP4 (a cAMP Efflux Pump) and the Beta 2 Andrenergic Receptor (an Upstream Regulator of cAMP Signaling Pathways
… that can efflux the second-messenger, cAMP, from cells. MRP4 has a PDZ interacting motif at its carboxy terminal end through which it binds to scaffolding proteins NHERF1 and PDZK1. Previous studies have shown that PDZK1 serves as a scaffold physically coupling MRP4 with the cystic fibrosis …
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Development of solid lipid nanoparticles for sustained release of anticancer agents
… are reviewed. The potential of SLN in anti-cancer drug delivery systems is highlighted. SLN formulations of two different lipids (tristearin, stearic acid), used as carriers for the encapsulation of the anticancer drug substance curcumin (CRC), have been investigated. The physicochemical …
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Application of Different Bioanalytical Workflows for Proteomics of Prostate Cancer
… for phosphoproteomic characterization in cell culture and clinical specimens of prostate cancer; and on the application of optimized methods to analysis of differential protein expression to reveal molecular mechanism of drug action in animal model of prostate cancer. </p> …
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Nuclear PTEN Regulates Thymidylate Biosynthesis and Cellular Sensitivity to Antifolate Treatment
… tumorigenesis and holds significant promise for cancer therapy. The PTEN tumor suppressor governs a variety of biological processes, including metabolism, by acting on distinct molecular targets in different subcellular compartments. In the cytoplasm, PTEN regulates a plethora of metabolic …