Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 50 for “"Human models"”.
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Mechanical and Biologic Impact of Dynamic Loading on Bovine and Human Models of Osteoarthritis
… and biochemical composition of cartilage in human osteochondral tissues when treated with exogenous inflammatory cytokines. Bovine knee cartilage and human ankle cartilage-bone explants were used in vitro with a cytokine challenged to mimic an OA disease state. A load-controlled dynamic …
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EPIGENETIC AND FUNCTIONAL ASSESSMENT OF ENHANCEROPATHIES ACROSS HUMAN MODELS: FOCUS ON GABRIELE-DE VRIES SYNDROME
… impact of this TF in the neurodevelopment of the human cortex is yet to be unraveled. By taking advantage of disease-modeling as a tool to investigate the pathogenesis of GADEVS across different time points and tissues we gathered new insights about how YY1 haploinsufficiency exerts such a …
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Impairments in signaling cascades mediating the progression of liver disease from chronic hepatitis to hepatocellular carcinoma in animal and human models
… hepatitis C (HCV) virus. Growing evidence from human studies and experimental models suggests that pre-degenerative and premalignant abnormalities include disturbances in intracellular signaling and ongoing injury with oxidative stress, inflammation, and lipotoxicity. The major signal …
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Investigation of the potential beneficial effects of supplemental polyunsaturated fatty acids and glycosaminoglycans on the risk factors for calcium oxalate kidney stone formation using theoretical, experimental and human models
… calcium and/or oxalate excretion in animal and human studies. The notion of CS playing a role in reducing CaOx stone risk is based on its chemical structure which presents potential binding sites for calcium and magnesium. The second hypothesis is that black and white healthy South African …
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The Tissue-reduced Virtual Family Models for RF-induced Heating Evaluation of Passive Medical Implants at 1.5 T and 3 T
… of patients. The study in ASTM phantom and human models is adopted to evaluate the RF-induced heating near the medical implants. To make the experiment in human models more practical, the tissue-reduced virtual family models were proposed for RF-induced heating simulation and possible …
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Analysis, Design, and Control of Supernumerary Robotic Limbs Coupled to a Human
… can reduce the load on targeted muscles of the human body during fatiguing tasks. It is common, however, that exoskeletons also increase the load at untargeted muscles, resulting in minimal to negative net improvement. Here, a novel wearable robot is designed and controlled based on human models …
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Optimization of culture conditions for equine bone marrow mesenchymal stem cells and their differentiation into osteoblasts
… research in this area has been in rodent and human models. The previous research has shown that MSC are an accessible and functional source for bone regeneration. Past work has increased understanding of the isolation, proliferation, and differentiation of MSC in rodent and human models. …
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Modelling neuronal mitochondrial aminoacyl-tRNA synthetase defects
… due to the lack of physiologically relevant human models, as current research relies primarily on non-human models or patient-derived fibroblasts that do not recapitulate the tissue-specific complexities of the nervous system. Here, I address this unmet need by applying tissue-specific human …
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Mitochondrial Metabolism in Ischaemia Reperfusion Injury
… drugs found to be promising in pre-clinical models fail to show efficacy in humans. Despite this, improving our understanding of the underlying pathophysiological mechanisms has supported the development of rational therapeutic approaches. Mitochondria are integral to IR injury, and the …
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Probabilistic Analysis of the Material and Shape Properties for Human Liver
… inter-subject variations into numerical human models. The main objective of this study was to quantify the variations in shape and material properties of the human liver. Statistical shape analysis was applied to analyze the geometrical variation using a surface set of 15 adult human …
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Distinguishing Medial Temporal Lobe and Prefrontal Cortex Contributions to Approach-Avoidance Conflict in Healthy Controls and Generalized Anxiety Disorder: Insights from Functional Magnetic Resonance Imaging and the Hierarchical Drift Diffusion Model
… decision-making. Across translational rodent and human models, AA conflict has been associated with anxiety and is supported by a network of brain regions including the medial temporal lobe (MTL), striatum, and prefrontal cortex (PFC). This work, however, is limited in two respects. (1) Human …
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Mouse models of osteoarthritis and joint injury
… The complexity of the disease makes the use of human models impractical and complicated. Therefore, various animal models have been developed to study the progression of OA and possible therapeutic techniques. Of those models, mouse models play an integral part because of their …
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Designing Behavior-Aware AI Systems to Influence Human Decision-Making
… intelligence (AI) demonstrates superiority over humans in many applications, such as image processing, speech recognition, and decision-making. AI systems are more efficient and accurate in information processing and computation, making them invaluable in assisting human decision-making across …
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Agent-based Crowd Simulation Modelling for a Gaming Environment
… a gaming environment. It can simulate realistic human crowds with user-controllable features to provide a gaming-like experience. Our approach features an enhanced rendering system based on Distinguishable Agents Generating Method (DAGM). This method can generate distinguishable and scalable 3D …
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A comparison of digital human model ergonomics outputs driven by optical and inertial motion capture systems in virtual reality
Digital human models (DHM), or virtual human avatars, can be used within digital virtual manufacturing to conduct proactive ergonomics analyses. Recent technological advancements have allowed for dynamic posturing of the DHM using motion capture technology and virtual reality immersion, providing a …
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A Stem Cell-Based Strategy for Modeling Human Kidney Disease and Discovering Novel Therapeutics
… strategy to protect or promote repair of injured human kidney tissues with an initial focus on glomerular podocytes. To achieve this goal, we leveraged advances in the directed differentiation of stem cells and in vitro disease modeling techniques to develop translationally relevant human models …
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The impact of whey protein consumption and exercise on the composition and diversity of the gut microbiota: a high through-put DNA sequencing approach
… which the gut microbiota plays in maintaining human health. Conversely, perturbations to the composition or actions of the ‘normal/functioning’ microbiota have been frequently associated with the pathogenesis of several disease states. Therefore the selective modulation of enteric microbial …
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Characterisation of cardiac cellular and vascular function in Ischemic heart disease
… with the Blackpool Victoria Hospital, human IMA and SV samples wereprovided for human tissue trials, which we supported with data from murine aortic control and eNOSknockout (eNOS-/-) models, by assessing the contractile and distensile properties via myography basedassays.In control …
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Molecular Mechanisms of Opioid Use Disorder in Human Brain Models
… with no end in sight. While studies from animal models hint at widespread epigenetic and transcriptomic alterations of opioid drugs, the molecular consequences of long-term exposure to opioid drugs in human brain is still unclear, and human-centered translational models are necessary to discern …
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White Beauty: The Portrayal of Minorities in Teen Beauty Magazines
… a total of 620 advertisements containing human models. After setting up a theoretical framework of the new racism and White beauty, this study investigates the portrayals of minority models. Overall, when compared with earlier studies the number of minority models used in mainstream …
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