Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"Human mitochondrial DNA"”.
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Human mitochondrial DNA and population structure of the Western Mediterranean Islands
… a comparative analysis of ancient and modern mitochondrial DNA (mtDNA). By integrating high-resolution mitogenomic data, the study aims to explore how migration, colonization processes, and long-term geographic isolation have shaped the genetic structure of insular populations over time. A …
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Theoretical and Statistical Approaches to Understand Human Mitochondrial DNA Heteroplasmy Inheritance
Mitochondrial DNA (mtDNA) mutations have been widely observed to cause a variety of human diseases, especially late-onset neurodegenerative disorders. The prevalence of mitochondrial diseases caused by mtDNA mutation is approximately 1 in 5,000 of the population. There is no effective way to treat …
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Human Mitochondrial DNA from 5th – 3rd Millennia BCE: An Analysis of Iberian Populations
… population dynamics are less clear. Ancient DNA data from the Neolithic period of coastal regions of the Iberian Peninsula are relatively scarce. The aim of the present study was to sequence DNA from Neolithic Iberians from the Spanish Levant (Catalonia) and the Portuguese Estremadura, …
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Achieving High Replication Fidelity by Intricate Communication between Two Active Sites and Efficient Use of Available Cofactors in Human Mitochondrial DNA Polymerase
… copies of its own genome. Proper maintenance of mitochondrial genome is important for proper function as mutations and deletions on mitochondrial DNA impairs oxidative phosphorylation and leads to mitochondrial dysfunction, clinically manifesting as cardiovascular, neurodegenerative, and muscular …
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Sequence Detection and Comparative Analysis of the Hv1 and Hv2 Control Regions of Human Mitochondrial DNA by Denaturing High-Performance Liquid Chromatography
… mixtures of non-concordant amplicons of human mitochondrial DNA (mtDNA). The reproducibility and efficacy of DHPLC results, including amplification reproducibility, injection reproducibility, and column-to-column reproducibility were measured, showing negligible assay-to-assay …
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Analysis of mitochondrial DNA variation in the Egyptian population and its implications for forensic DNA analysis
The genetic sequence of human mitochondrial DNA (mtDNA) is of particular interest to forensic investigations involving human identification, as well as population genetics. The current mtDNA database is lacking sufficient representatives of African mitochondrial DNA sequences compared to European …
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Ancient DNA from pre-Columbian South America
Ancient DNA (aDNA) research in the Americas represents a genetic strategy to investigate demographic and historical events of populations in the continent with the added bonus of having a direct and temporal perspective. This thesis aims to explore human mitochondrial DNA (mtDNA) diversity from a …