Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"Human microglia"”.
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Adult Human Microglia: Phenotypic Diversity and Functional Complexity
… system (CNS) throughout health and disease. Microglia are the resident immune cells of the CNS. Present throughout the brain parenchyma and in constant communication with the peripheral immune system, microglia are essential regulators of brain physiology. The adult human brain is prone to …
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Effects of carnosine in experimental models of neuroinflammation: focus on human microglia [Effetti della carnosina in modelli sperimentali di neuroinfiammazione: focus sulla microglia umana]
La microglia, le cellule immunitarie del cervello, sono essenziali per lo sviluppo del cervello, la plasticità sinaptica e la neurogenesi, essendo responsabili del mantenimento dell'equilibrio eliminando proteine mal ripiegate e cellule morte. La perdita dello stato omeostatico della microglia è …
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Development and Characterization of Selective CB2R Inverse Agonists as a Novel Anti-Inflammatory Therapy for Neuroinflammation – Mechanisms of Action in Murine and Human Microglia Models Provide Valuable Insights into Their Therapeutic Potential
… such as Alzheimer’s (AD), Parkinson’s (PD), Human Immunodeficiency Virus (HIV) and Multiple Sclerosis (MS). The restricted and upregulated expression of CB2R in activated microglia and lack of psychotropic activity make this receptor an attractive target for discovering novel therapy to treat …
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The Transcriptional Profile of Microglia: From Brain to Dish
The Transcriptional Profile of Microglia: from Brain to Dish Fiona Elizabeth Calvert Microglia are the tissue resident macrophages of the central nervous system (CNS) and multiple lines of evidence indicate that microglia are a pathogenic cell type in Alzheimer’s disease (AD). It is important to …
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The involvement of microglial activation in schizophrenia
Abnormal activation of brain microglial cells is widely implicated in the pathogenesis of schizophrenia. The disrupted balance of microglia phenotypes has been hypothesized to influence the clinical course of the disease and affect symptom severity. Previously, the pathophysiology of microglial …
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The effects of the Parkinson’s disease-associated proteins LRRK2 and TMEM175 on the lysosomal profile of cultured mammalian cells under lysosomal stress conditions
… A549 cells with distinct LRRK2 genotypes, and in human and mouse microglial lines under basal conditions and lysosomal stress. The pathogenic PD-associated LRRK2 mutations have been shown to increase LRRK2 kinase activity, causing increased phosphorylation of its Rab GTPase substrates. This study …
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Immunogenetic Study of Autoimmunity-Associated Variants in Selected TNF Superfamily Genes
Major advances in human genetics have paved the way for the development of Genome Wide Association Studies (GWAS) in an effort to understand complex traits - including autoimmune diseases such as Multiple Sclerosis (MS). Using unbiased genome screens of affected individuals and appropriately …
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THE ROLE OF P2X7R IN METHAMPHETAMINE-INDUCED BEHAVIORAL CHANGES AND MICROGLIAL EFFECTOR FUNCTIONS
… verbal learning. Current literature implicates microglia, the resident macrophages of the CNS, as major mediators of the neurological side effects. Upon activation, microglia undergo a morphological change to an amoeboid shape with increased capacity for migration, phagocytosis and cytokine …
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CHCHD2 and the tumor microenvironment in glioblastoma
… and biophysical cues, tumor-associated microglia and macrophages represent a substantial portion of GBM tumors and play a critical role in cultivating a microenvironment that facilitates tumor expansion. Chapter six focuses on examination of the crosstalk between microglia and GBM cells …