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Showing 1 to 19 of 19 for “"Human mesenchymal stem cell"”.
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Human Mesenchymal Stem Cell Homing to Glioma Stem Cell Xenografts
… and the microsatellite populations of tumor cells scattered throughout the brain parenchyma. However, bone marrow-derived human mesenchymal stem cells (hMSCs) offer a viable alternative to enhance therapeutic delivery – one that overcomes current limitations. hMSCs are a population of cells …
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Investigation of human mesenchymal stem cell genetic characteristics to ensure therapy safety /
Human mesenchymal stem cell (MSC) therapy holds promise for treating degenerative and immune system diseases and repair of damaged tissues. Human tissues are cryopreserved and isolated MSCs are expanded in various culture media when prepared for clinical applications. These manipulations can …
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Proteomic Analysis of Human Mesenchymal Stem Cell Aging during serial sub-culture
"Human mesenchymal stem cells (hMSCs) hold great potential for clinical applications in regenerative medicine. However, hMSCs occur at a very low frequency in bone marrow so the clinical use as cellular therapeutics requires suitable techniques for isolation and expansion. Furthermore, these cells …
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Quantitative correlations among human mesenchymal stem cell mechanical properties and biological function
Mesenchymal stem cells (MSCs) are derived from bone marrow, and are capable of proliferating and differentiating along multiple pathways such as osteoblasts, chondrocytes and adipocytes. MSCs offer the means for regenerative therapies not possible with conventional small molecule/antibody/ nucleic …
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Neuroprotective Effect of Human Mesenchymal Stem Cell on Dopaminergic Neurons by Anti-inflammatory Action
… PD. The present study was to evaluate effect of human bone marrow-derived mesenchymal stem cell (hMSCs) on modulation of neuroinflammation. We used lipopolysaccharide (LPS)-induced in vitro and in vivo inflammation models to investigate whether hMSCs have a protective effect on the dopaminergic …
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Analysis of Therapeutic Effect after Human Mesenchymal Stem Cell Transplantation in Ischemic Stroke Rat
Background and PURPOSE: Mesenchymal stem cells (MSCs) have recently been investigated as an attractive therapeutic tool for ischemic stroke because of their plasticity and availability. For the understanding of therapeutic effect of MSCs after transplantation in ischemic rats, changes in free fatty …
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Differential human mesenchymal stem cell responses across multi-compartment scaffolds for tendon-bone regeneration
… increasing interdigitation. Next, we examined cellular response after tensile strain across two multi-compartment scaffold variants, one containing only a mineral gradient (layered) and the other incorporating microstructural alignment characteristic of the native osteotendinous interface …
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In vitro evaluation of human mesenchymal stem cell neural differentiation on tyrsine-derived polyarylates and polycarbonates
… can return in the hopes of repairing the neural cells with a tissue engineered designed scaffold complex. The scaffold complex will include cells to repair and replace the damaged cells. Mesenchymal stem cells (MSC) are multipotent adult stem ells that are capable of differentiating along several …
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Neuronal Differentiation and Functional Recovery after Transplantation of Human Mesenchymal Stem Cell in The Ischemic Rat Model
… disease, Huntington's disease and Stroke. Human mesenchymal stem cells are pluripotent stem cells, which can be differentiated into mesenchymal lineage cells. Those cells from the individual patient have the advantage to minimize the immune rejection. In this study, cytokine-inducted human …
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Role of Wnt signaling in proliferation of human bone marrow-derived mesenchymal stem cells
Human mesenchymal stem cell (hMSC) is an attractive source of adult stem cells for the therapeutic use in regenerative medicine. These cells are usually culture expanded prior to their application. However, their proliferation and differentiation potential were gradually decreased during in vitro …
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뇌종양 치료 목적의 시토신데아미나아제를 발현하는 인간 중간엽 줄기세포의 임상용 치료제 생산 공정 개발
인간 중간엽 줄기세포 (Human Mesenchymal Stem Cell ;hMSCs)는 병변 부위나 종양부위로 이동할 수 있는 능력을 가지고 있어 다양한 질병의 ex-vivo 치료에 치료유전자를 전달하는 능력을 지닌 매개체로 많이 연구되고 있다. 하지만 유전자 변형을 유도한 중간엽 줄기세포는 보통 바이러스벡터를 기반으로 하기 때문에 임상적으로 사용하기에는 여전히 우려되는 점이 있다. 우리는 hMSC에 레트로바이러스 벡터 (Retro-virus)를 사용하여 시토신데아미나아제를 발현하는 MSCs (MSC/CD)를 제작한 후 마스터 …
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Žmogaus mezenchiminių kamieninių ląstelių genetinių savybių tyrimas saugiai terapijai užtikrinti /
Human mesenchymal stem cell (MSC) therapy holds promise for treating degenerative and immune system diseases and repair of damaged tissues. Human tissues are cryopreserved and isolated MSCs are expanded in various culture media when prepared for clinical applications. These manipulations can …
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Osteogenic differentiation of human mesenchymal stem cells on thin film tyrosine derived polycarbonates
Mesenchymal stem cells, harvested from adult bone marrow, are promising in the field of regenerative medicine because of the vast differentiation potential into various cell lines such as: osteoblasts, chondrocytes, adipocytes, and neurons. Osteogenic differentiation of human mesenchymal stem cells …
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Control of proliferation in human mesenchymal stem cells by Secreted Frizzled Related Protein 1
Human mesenchymal stem cell (hMSC) is adult stem cell that is useful tool for a various disease. However, it has limitations that lost proliferation and differentiation ability in long-term in vitro culture and occurred senescence. This study would like to confirm the relationship between Wnt …
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Effect of platelet factors and thrombin on multiplication of human bone marrow mesenchymal stem cells cultured in low and high oxygen level in vitro
… In the bone marrow, hematopoietic and mesenchymal stem cells form a unique niche, in which oxygen tension is low. Hypoxia may have a role in maintaining stem cell capacity for self-renewal and multipotency. We have shown previously a positive influence of platelet-derived growth factors …
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Mechanical stiffness-defined matrices for stem cell research and drug screening
… provide a powerful method to direct biological cell' differentiation and foster cell multiplication. By changing the stiffness of the substrate, human mesenchymal stem cell (MSCs) could be directed along neuronal, muscle, or bone lineages. Matrix elastic modulus can also control anchorage …
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Modulation of mesenchymal stem cell invasion into decellularized engineered tissues
… the organization and alignment of the extracellular matrix (ECM) in developing and mature tissues, where the organization gives the tissue its unique functional properties. This dissertation will discuss research that is fundamental to the understanding of the interaction of cells with the …
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Factors affecting neurogenesis after application of human mesenchymal stem cells in ischemic rat model
… trial of ex vivo culture expanded autologous mesenchymal stem cells (MSCs) in patients with severe ischemic stroke. We proposed that an optimal condition, for either donor or recipient, may exist and enhance the effects of the mesenchymal stem cells in those patients. Thus we evaluated the …
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A patient specific total disc replacement to treat degenerative disc disease
… evaluate its capacity to support regenerative cell responses under physiological cyclic loads. Finite element (FE) modelling was used as a prescriptive rather than descriptive tool to guide the design of a scaffold-based TDR capable of matching physiological stiffness in compression, …