Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"Human melanoma cells"”.
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RNA-sequence analysis of human melanoma cells
… study, complementary DNA fragments of cultured human melanoma cells are sequenced and a total of 139,501,106 million 200-bp reads from two samples affected with the disease are obtained. The RNA-seq is performed by first mapping the sequence reads to the reference human genome sequence (NCBI …
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An experimental study of human melanoma cells cutured in vitro
… that were designed to examine the biology of human malignant melanoma cells cultured in vitro. The studies were so planned as to document phenotypic differences that exist between melanomas, to define respects in which melanoma cell differentiation could be modulated and to correlate …
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Proteolytic mechanisms involved in the metastasis of human melanoma cells
The metastatic process requires that tumour cells are capable of traversing various micro-environmental barriers, such as the basement membrane. There are various proteolytic mechanisms which could contribute to the process, plasminogen activation by tissue plasminogen activator (tPA) and urokinase …
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Characterization of a plasminogen activator from human melanoma cells cultured in vitro
… activator, Mel-PA, that is released by human melanoma cells cultured in vitro. This enzyme was compared to the urinary plasminogen activator, urokinase. The human melanoma cell line, RPMI-7272, (also referred to as the "Bowes" melanoma cell line) released large amounts of Mel-PA into the …
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TRPML1 Promotes Protein Homeostasis in Melanoma Cells by Negatively Regulating MAPK and mTORC1 Signaling
A major goal of studying melanoma is to identify therapeutic vulnerabilities that can be exploited to improve patient treatment. Melanoma cells are particularly sensitive to perturbations in ion homeostasis, especially when ion gradients are perturbed in combination with MAP kinase inhibition. I …
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Mouse Melanoma Model for Evaluating Anti-Cancer Effects of Nanoparticles, Composites and Conjugates
Melanoma is a detrimental cancer due to its ability to evade the immune system and replicate uncontrollably. Tumor cells are thought to change their local microenvironment, both to evade the repression by the immune system and to use expressed cytokines and factors for their advanced growth and …
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Metabolomic Investigation of Melanoma Metastasis in a Patient-Derived Xenograft Mouse Model
… set of patient-derived xenograft mouse models of melanoma, in which the metastatic potential of individual tumor lines correlated strongly with the history of metastasis in the patient donors. Six tumor lines with low metastatic potential (L-met) and nine with high metastatic potential (H-met) …
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Guanidinium Compounds: Synthesis, Oxoanion Binding, and Cellular Delivery
The delivery of biological molecules into cells has been an issue of importance in both chemical biology and drug discovery. One method used to transport biologics into cells is the cellpenetrating peptide (CPP). This arginine-rich peptide forms strong interactions with the cell surface through …
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Targeting Neuronal Nitric Oxide Synthase (nNOS) for Melanoma Treatment
<p>Human cutaneous melanoma is the most aggressive form of skin cancer and the incidence rates have continued to increase over the years. Neuronal nitric oxide synthase (nNOS) produces nitric oxide (NO) has been found to be overexpressed in human melanoma and the expression of nNOS is induced by …
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Role of DNA repair protein ERCC1 in skin cancer
… oxidative lesions. Defects in NER result in the human inherited disorder xeroderma pigmentosum (XP), which is characterised by UV hypersensitivity and a 1000-fold increased risk of skin cancer. ERCC1 is essential for the NER pathway where it acts in a complex with the XPF protein to make the …
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Approaches for Enhancing Therapeutic Efficacy of a Novel IL-10 Gene Family Member: MDA-7/IL-24
<p>Melanoma differentiation associated gene-7 (mda-7) was discovered in the Fisher laboratory by subtraction hybridization of temporally spaced subtracted cDNA libraries prepared from terminally differentiated human melanoma cells treated with human fibroblast interferon (IFN-β) and the protein …