Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 56 for “"Human macrophages"”.
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Characterization of cholesterol 25-hydroxylase expression in human macrophages
… of this connection appear to differ in mouse and human cells. Nevertheless, the molecular basis for the induction of CH25H in humans is not known. Objective Elucidation of signaling and transcriptional events for induction of CH25H expression is critical to design therapeutic antiviral agents. …
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Mechanisms underlying Leishmania parasites survival and dissemination at late stage of infection in human macrophages
… are the causative agent of a wide range of human diseases known as leishmaniasis. The progression of disease pathogenesis is dependent on the ability of intracellular parasites to disseminate between human macrophages. It is assumed that parasites could exit macrophages following cell lysis. …
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Generation and therapeutic evaluation of recombinant immunotherapeutics on CD64+ monocytic cell lines and polarized ex vivo differentiated human macrophages
Introduction: Dysfunctional monocytes/macrophages have been associated with the initiation and maintenance of several chronic diseases such as rheumatoid arthritis (RA), cancer, atopic dermatitis (AD), leishmaniasis etc. In RA for example, the imbalance between pro-inflammatory and …
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Establishing an ex vivo model of acanthamoeba keratitis and investigating the phenotypic similarities between the protozoan acanthamoeba and human macrophages
… species are opportunistic pathogens of humans that cause two main diseases including a potentially blinding infection of the cornea called Acanthamoeba keratitis (AK) in immunocompetent individuals, and a fatal granulomatous encephalitis in the immunocompromised. In this study, an ex …
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The role of Poly (ADP-ribose) polymerase in the regulation of innate recognition of immunological receptors expressed on human macrophages.
… (MARCO). These receptors are expressed on most human monocytes and macrophages. CD14 recognizes and bind lipopolysaccharide (LPS), the main causative agents of sepsis and endotoxic shock. Signaling from CD14-LPS and TLR4/MD-2 complex activate the nuclear factor kappa B (NF-κB) family of …
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The immunological role of cell wall components from diverse Mycobacterium tuberculosis clinical isolates in regulating HIV-1 replication in human macrophages
Human immunodeficiency virus type 1 (HIV-1) and Mycobacterium tuberculosis (Mtb) coinfection remains a major global health threat. Both pathogens synergistically drive pathogenesis of the other. The risk of developing active tuberculosis (TB) is increased in people living with HIV-1, even in those …
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Human mesenchymal stromal cell regulation of pulmonary macrophage populations in the Acute Respiratory Distress Syndrome
… effective pharmacological therapies available. Human Mesenchymal Stromal Cells (hMSCs) are a promising candidate therapy which are currently being investigated in clinical trials for ARDS. However their mechanisms of effects in lung injury are not fully elucidated. A fuller understanding of …
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The role and host-directed targeting of long non-coding RNAs in macrophage polarization during Mycobacterium tuberculosis infection
… stimulated (alternatively activated) mouse macrophages, identifying 151 differentially expressed lncRNAs following Mtb infection. We validated the top 11 differentially expressed lncRNAs and two were chosen for this study, lncRNA-125, whose expression was regulated at different levels …
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ST2 & TLRs: coordination of chemokine-driven immunity
… and potential role of these ST2 molecules in human macrophages has been investigated. Following the discovery of IL-33 as a ligand for ST2, the effect of this ligand on human macrophages was explored. We found elevated levels of the soluble form of ST2 (sST2) in the synovial fluid (SF) of …
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Analysis of Macrophage-‐Derived Inflammatory Response in the Presence of Glycosaminoglycans: A Possible Clue on the Role of Inflammation in the Pathogenesis of Morquio A
… as well as some specific cell types such as macrophages. This suggests that MPS IVA is a systemic disease that may disrupt cellular homeostasis throughout the body. Recent work on mucopolysaccharidoses and KS has produced two opposing models to explain the repercussions of KS accumulation. …
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Understanding and Exploiting Wnt5a and GSK3 Signaling in Inflammatory Disease
… density lipoprotein (ox-LDL) by monocytes/macrophages plays a critical role in the pathogenesis of atherosclerosis. The importance of macrophages in the development of an atherosclerotic plaque has been well documented. Wnt5a, a secreted glycoprotein, is highly present in atherosclerotic …
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Mechanisms of Macrophage Detection and Control of Mycobacterium tuberculosis Infection
Macrophages use different mechanisms to recognize and respond to Mycobacterium tuberculosis infection. Macrophage recognition of M. tuberculosis is characterized by the production of a robust type I interferon response dependent on the activation of a cytosolic surveillance pathway by the …
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Investigation of ACE-overexpression in Myeloid Cell Lines through Whole-Proteome Analysis
… of angiotensin II, ACE overexpression in murine macrophages (ACE 10/10) and neutrophils (NeuACE) has shown remarkable enhanced immune phenotypes with the ability to improve murine survival against B16 melanoma, methicillin-resistant Staphylococcus aureus (MRSA) and Listeria monocytogenes. Current …
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Human Chimeric Antigen Receptor Macrophages For Cancer Immunotherapy
… (CAR) T cell immunotherapy for the treatment of human cancer, metastatic solid tumors remain an intractable challenge. Myeloid cells are actively recruited to the tumor microenvironment (TME), where tumor associated macrophages (TAMs) are often the most abundant infiltrating immune cell. …
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Development Of New Therapy to Combat Tuberculosis Induced Inflammation
… the pro-inflammatory cytokines, TNF and IL-6, in human macrophages. Treatment of M. tuberculosis infected mice with FhHDM-1 also significantly reduced lung inflammation without reducing control of the bacteria. This research identified two pathways to reduce inflammation during M. tuberculosis …
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Macrophage Polarization (M1/M2) and its Role in Wnt5a Secretion/Expression in Atherosclerosis
<p>Macrophages play an important role in the formation of atherosclerotic lesions and their progression. The presence of M1 and M2 macrophages in human atherosclerotic lesions has been suggested. Wnt5a is a noncanonical member of the wingless family of proteins that is expressed in human …
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Characterisation of YGT a novel Type III secretion system in Biotype 1A Yersinia enterocolitica strain YE53/03
… pathogens, causing gastrointestinal disease in humans, with symptoms resembling those caused by Y. enterocolitica pathogenic strains. Furthermore, some BT 1A strains were found to be able to persist inside human macrophages and epithelial cells, and colonise mouse organs, in a mouse model of …
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Role of Vitamin-D3 and Retinoic Acid In A Human Thp-1 Macrophage Model of Mycobacterium Tuberculosis Infection
… tuberculosis (Mtb) replicates within the human macrophages and we investigated the activating effects of retinoic acid (RA) and vitamin D3 (VD) on macrophages in relation to the viability of Mtb. A combination of these vitamins (RAVD) enhanced the receptors on THP-1 macrophage (Mannose …
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Studies of hyperphosphorylated tau aggregation and cytotoxicity
… Toll-like receptor 4-dependent responses in human macrophages. We also found that non-phosphorylated tau could polymerize into amorphous, cytotoxic aggregates when induced by hyperphosphorylated tau in situ, having similar structural and functional properties to the self-assembled …
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