Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 31 for “"Human lymphocytes"”.
-
Identification of interacting partners of mammalian target of rapamycin complex 1 (mTORC1) assembly in human lymphocytes
… cell survival, and cell proliferation. In humans, mTOR deregulation is implicated in parasitic, fungal, bacterial and viral infections, immune disorders, diabetes, obesity, cardiac diseases, renal abnormalities, and various cancers. mTOR was first identified as TOR in Saccharomyces …
-
Characterization of a Novel Receptor CS1 in Human Lymphocytes; Studies in Natural Killer Cells and B-Lymphocytes
… study was to investigate the roles of CS1 on human lymphocytes. The molecular and functional characterization of CS1 receptor in the natural killer (NK) cells and B lymphocytes was investigated. CS1 (CRACC, novel Ly9) is a novel member of the CD2 family receptor expressed on natural killer …
-
Derivation of lymphocytes from human induced pluripotent stem cells
Human pluripotent stem cells have the potential to produce essentially unlimited numbers of mature and functional blood lineage populations to study human hematopoiesis. Particularly, human induced pluripotent stem cells (hiPSCs) have the advantage to provide a source of autologous transplantable …
-
Inactivation synergy between high energy neutrons and ⁶⁰Co gamma rays
… using mammalian cells, meristematic cells and human lymphocytes. The quality of each radiation source was quantified in terms of molecular yield per unit dose absorbed in a ferrous sulphate xylenol orange solution and was found to vary inversely with the mean LET of the radiation field. …
-
Protecting Healthy Cells Against the Negative Effects of Radiation Therapy for Lung Cancer
… therapy is a commonly used treatment for many human diseases including cancer, ionizing radiation produces reactive oxygen species that can damage both cancer and healthy cells. Synthetic triterpenoids, including CDDO-Me, act as anti-inflammatory, antioxidant modulators primarily by inducing …
-
Investigation of a Novel Formulation from Umbilical Cord Blood Stem Cell-Derived Exosomes and Antioxidant (Selenium) in Malignant Melanoma Cells
… exosomes, individually and in combination, on lymphocytes from MM patients and healthy controls, and on the CHL-1 melanoma cell line. The comet assay and cell counting kit-8 (CCK-8) assay were used to measure genotoxicity and cytotoxicity, respectively, in all cell types. Molecular mechanisms …
-
Investigation of a Novel Formulation from Umbilical Cord Blood Stem Cell-Derived Exosomes and Antioxidant (Selenium) in Malignant Melanoma Cells
… exosomes, individually and in combination, on lymphocytes from MM patients and healthy controls, and on the CHL-1 melanoma cell line. The comet assay and cell counting kit-8 (CCK-8) assay were used to measure genotoxicity and cytotoxicity, respectively, in all cell types. Molecular mechanisms …
-
Development and Evaluation of Organometallic Anticancer Drug Candidates
… cytotoxicity of these complexes against various human cancer cell lines is presented, as well as preliminary studies on their possible modes of action, determined via gene expression studies, cell cycle and apoptosis analysis, reactive oxygen species detection and mitochondrial-membrane potential …
-
Development and Evaluation of Organometallic Anticancer Drug Candidates
… cytotoxicity of these complexes against various human cancer cell lines is presented, as well as preliminary studies on their possible modes of action, determined via gene expression studies, cell cycle and apoptosis analysis, reactive oxygen species detection and mitochondrial-membrane potential …
-
A Comparison of Two 'In Vitro' Assays to Assess Radiosensitivity in Patients Receiving Radiotherapy
… rapid means to assess DNA damage and repair in human lymphocytes. NLS involves the centrifugation of histone-free DNA (HF-DNA) through a neutral 0-20% sucrose gradient - where DNA damage in a population of lymphocytes is detected as an upward shift in HF-DNA sedimentation distance. MGE involves …
-
Applications of a novel assay to investigate variation in DNA repair in human populations.
… optimise an assay for assessing DNA repair in human lymphocytes and to use this assay in population studies. DNA repair has not been studied extensively in human populations due to the difficulty of finding a suitable assay for its measurement. This thesis describes the development and …
-
Photobiomodulation with IR1072nm in the murine CNS: in vitro and in vivo studies
… have protective effects against UVA toxicity in human lymphocytes and beneficial effects on working memory in IR-treated 12 month old CD-1 mice. The aim of this investigation was to establish the beneficial effects of IR1072 in the murine mammalian CNS utilising a range of in vivo and in vitro …
-
Lymphocyte populations and their relationship to cell-mediated immune responses in aflatoxin-treated guinea pigs
… hypersensitivity (DTH) was used to evaluate T lymphocytes or macrophages from aflatoxin-treated guinea pigs. The skin test responses of both nontreated guinea pigs receiving peritoneal exudate cells (PEC) from aflatoxin-treated guinea pigs and aflatoxin-treated guinea pigs receiving PEC from …
-
Mucosal HIV-1 Transmission in Humanized Mice
… HIV-1 transmission, the susceptibility of humanized mice to intrarectal and intravaginal HIV-1 infection was investigated. Human lymphocytes, including CD4+ T cells, generated in situ from hematopoietic stem cells reconstitute the gastrointestinal tract and the female reproductive tract of …
-
The Mode of Action of Immunoregulatory Alpha Globulin (IRA) on Murine Lymphocytes: Relation of the Immunosuppressive Activity of Various Pathologic Conditions
… components in the alpha globulin fractions of human and murine sera (1, 2, 3, 4, 5, 6, 7, 8, 9). These investigations shed new insights on the mechanisms controlling immune responses in normal individuals, and may elucidate the specific mechanisms involved in producing immune deficiency …
-
Genotoxic effects of nano and bulk forms of aspirin and ibuprofen on blood samples from prostate cancer patients compared to those from healthy individuals: The protective effects of NSAIDs against oxidative damage, quantification of DNA repair capacity and major signal transduction pathways in lymphocytes from healthy individuals and prostate cancer patients
… the genotoxicity mechanisms of NSAIDs agents in lymphocytes. In this study, the genotoxicity mechanisms of NSAID in bulk and nanoparticles forms a strategy to prevent and minimise the damage in human lymphocytes. Aspirin nano (ASP N) caused a significant decrease in deoxyribonucleic acid (DNA) …
-
The role of GPR65 and GALC in Multiple Sclerosis: Establishing the functional consequences of an MS associated variant on chromosome 14q31.3
… system I was able to show that the activation of human lymphocytes to stimulation with anti-CD3/CD28 antibodies is maximal at neutral pH and reduced in both acidic and alkaline conditions. Unfortunately, I was unable to replicate the provisional finding that carrying the protective allele at …
-
Lymphocyte subset variability between human lymphoid tissues
Most adaptive immune lymphocytes are in the lymphoid tissues. However, studies of human lymphocytes to date have primarily investigated cells from the blood, and lymphoid tissues remain poorly studied. This thesis explores the hypothesis that there is local variation of B cell subsets between the …
-
Effect of nanoparticles on human cells from healthy individuals and patients with respiratory diseases.
… effect of nanoparticles from these compounds in human germ cells. Thus the present study has examined their effects in the presence and absence of UV light in human sperm and compared responses to those obtained with human lymphocytes using the Comet assay to measure DNA damage. The effect of …
Page 1 of 2