Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 137 for “"Human lung"”.
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Expression of antimicrobial peptides in human lung tissue
Lunga mannsins er mjög flókið líffæri sem er samansett af pípulaga líffærakerfi sem tengist andrúmsloftinu í gegnum öndunarveginn. Í lunganu eiga sér stað loftskipti á súrefni og koltvíoxíði og þarf lungað því að hafa vel skipulagt ónæmiskerfi. Þegar lofti er andað inn í lungun fylgja mikið magn af …
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Hypoxia signalling regulates human lung epithelial cell fates
Human embryos develop in an environment with low oxygen tension (< 5% O2) during the first trimester. Hypoxia substantially impacts mammalian development and tissue homeostasis. However, it remains unclear whether and how hypoxia directly affects human lung epithelial development. In this PhD …
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Exploration of B cell diversity in the human lung
… aware of the presence of a microbiome within the human lung. The constant presence of microorganisms requires a regulated immune system that can differentiate between infectious organisms and non-infectious commensals. B cells in the lungs are a key member of adaptive immunity by producing antigen …
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The Cytotoxic Effects of Malondialdehyde on Human Lung Fibroblast Cells
… to investigate the toxic effects of MDA on the human lung fibroblasts MRC5, which have an intact p53 response, and their SV40 transformed counterpart, MRC5 SV2, which have a sequestered p53 response. Both cell lines were treated with MDA (0-1000 µM) for 24 and 48 h and subjected to a variety of …
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Numerical modeling of forced expiratory flow in a human lung
Thesis (M.S.)--Massachusetts Institute of Technology, Dept. of Aeronautics and Astronautics, 1992.
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Effects of Asthma Combination Therapy on Extracellular Matrix Remodeling in Human Lung Fibroblasts
… one of the resident and structural cells of the lung, have the capacity to produce inflammatory mediators, cytokines and extracellular matrix (ECM) proteins perpetuating the inflammation in the airways of asthmatics. Airway remodeling is also a prominent feature of asthma that affects the lung …
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The effect of insulin-like growth factor-I (IGF-I), and an IGF-I-like factor secreted by human lung fibroblasts, on the growth of human lung carcinoma cells in vitro
… growth factor I (IGF-I) in tissue taken from human non-small cell lung carcinoma (NSCLC) is 1.4- to 7-fold higher than the concentration of IGF-I in the surrounding normal lung tissue and therefore IGF-I may be involved in the growth of NSCLC. In this study it was determined that NSCLC cell …
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An immune-competent microvascularized human lung-on-chip device for studying immunopathologies of the lung
… models and in vitro, fail to recapitulate the human immune response to severe viral infection accurately. Here, we bioengineered a human lung tissue model that represents small airway structures with tissue-resident and circulatory immune cells. The immune-competent lung tissue model comprises …
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Differential proteome analysis of human lung epithelial cells following exposure to aromatic volatile organic compounds
… organic compounds (VOC) has lead to a general human exposure to these chemicals in work places or homes being suspected to contribute to the growing incidence of environmental diseases. Since the causal molecular mechanisms for the development of these disorders are not completely understood, …
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Studying the Effect of Low Doses of Ionization Radiation on Senescence in Human Lung Fibroblasts.
… the senescence effects of LDR exposure to normal human HFL1 cells and examined transcriptional changes. I found that HFL1 cells exposed to 10 mGy of gamma radiation had delayed senescence measured at 12 weeks post-irradiation compared to unirradiated cells. Through qPCR array analysis, I found …
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Development and Utilization of a Bioengineered 3D Human Lung Model to Study Pathogenesis of Lung Disease
… is a great need for research models that mimic human lung physiology and lung pathologies such as chronic lung diseases and respiratory infections. The morbidity and mortality associated with lung disease and respiratory infections represent a global burden. Pathogenesis of these diseases and …
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STUDYING THE INTERACTION OF NANO- & MICROPLASTICS WITH ENTEROVIRUS AND THEIR CYTOTOXICITY ON HUMAN LUNG CELL LINE
… can be ingested by living organisms, including humans. These particles are of concern due to their ability to adsorb contaminants and their potential long-term cellular effects. This study investigated the interaction between enterovirus D68 (EV-D68) and charged nano- and microplastics, as well …
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Investigation of the Biological Effects of Rosemary (Rosmarinus Officinalis L.) Extract in Human Lung Cancer Cells
… growth rates and a resistance to apoptosis. Lung cancer accounts for the most cancer related deaths and non-small cell lung cancer (NSCLC) represents an aggressive form of lung cancer, accounting for almost 80% of all lung cancer cases. The phytochemical rosemary extract (RE) has been …
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Expression of Prxiredoxin I, III and Thioredoxin in human lung cancer and the normal lung tissues
… may co-exist in many solid tumors, such as lung cancer. The relatively new family of novel antioxidant proteins, peroxiredoxins (Prxs), have been implicated in regulating many cellular processes including cell proliferations, differentiation, and apoptosis. They are also reported to function …
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Nrf2-Dependent Overexpression of Sulfiredoxin and Peroxiredoxin III in Human Lung Cancer, Especially Squamous Cell Carcinoma
… in A549 cells 12 B. Oxidation of Prx III in mink lung epithelial cells 12 C. Srx dependent regulation of Prx III oxidation in A549 cells 15 D. Srx is translocated into the mitochondria under oxidative stress 15 E. Overexpression of Prx I and III isoforms in human lung cancer 19 F. Nrf2 dependent …
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Differentiation of Normal and Cystic Fibrosis Human Lung Epithelial Cells in a Decellularized and Reconstituted Mouse Lung
Engineered lung tissue may eventually address the chronic shortage of transplantable lung tissue and permit modeling of lung disease in a controlled ex vivo environment. However, there are presently no sources of primary lung stem cells which can be expanded at sufficient scale to permit …
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Understanding the Effect Of 1,3-Butadiene on Human Lung Fibroblasts: Does Exposure to 1,3-Butadiene Induce Senescence?
… cigarette smoke extract induces senescence in lung fibroblasts and alveolar epithelial cells. 1,2,3,4-diexpoxybutane, or diepoxybutane (DEB), is the most reactive metabolite of 1,3-butadiene, an important hazardous air pollutant and potent genotoxic agent found in cigarette smoke. In this study …
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