Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 22 for “"Human immunodeficiency virus-1"”.
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MODELING AND MODULATING MYELOID CELL-MEDIATED NEUROINFLAMMATION FOLLOWING HUMAN IMMUNODEFICIENCY VIRUS-1 INFECTION
Human immunodeficiency virus 1 (HIV) infects myeloid cells in the central nervous system (CNS) and establishes a reservoir that persists despite antiretroviral therapy (ART). Infection leads to a 30-50% risk of developing HIV-associated neurocognitive disorders (HAND), a collection of mood, motor, …
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Gene Expression Changes in Immune Cells During Human Immunodeficiency Virus 1 (HIV-1) Infection
Human immunodeficiency virus infection is a chronic condition causing significant changes in the immune system, which are reflected in the altered gene expression patterns of the immune cells. By studying these patterns through gene expression profiling it is possible to describe not only the …
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Co-occurrence of shedding Herpes Simplex Virus type-2 (HSV-2), Human Papilloma Virus (HPV) and Human Immunodeficiency Virus 1 (HIV-1) in the female genital tract among HIV-infected women
Introduction: Human Immunodeficiency Virus remains as one of the largest pandemics in the world, with the prevalence of more than 70% of HIV-infected individual reside in Sub-Saharan Africa. Moreover, other sexually transmitted viral infection such as Human Papillomavirus and Herpes Simplex Virus …
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Origin and Correlates of Viral Rebound in SIV-Infected Rhesus Macaques Following Discontinuation of ART
… discontinuation of ART in people living with Human Immunodeficiency Virus-1 remain largely unknown. We investigated detailed reservoir characteristics and viral rebound dynamics in 18 Simian Immunodeficiency Virus-infected rhesus macaques treated with antiretroviral therapy for 70 weeks and …
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The Rev-mediated Dimerization of HIV RRE RNA
… critical for the late-phase development of the Human Immunodeficiency Virus-1 (HIV-1). During early-phase development of HIV-1, Rev accumulates in the cytoplasm and is transported into the nucleus through interactions with Importin-β via its Nuclear Localization Sequence (NLS). Following …
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The Rev-mediated Dimerization of HIV RRE RNA
… critical for the late-phase development of the Human Immunodeficiency Virus-1 (HIV-1). During early-phase development of HIV-1, Rev accumulates in the cytoplasm and is transported into the nucleus through interactions with Importin-β via its Nuclear Localization Sequence (NLS). Following …
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The Effect of the Incorporation of Heavy Metal Zeolites into 3-D Printed Surgical Guide Resin on the Surface Stability of SARS-CoV-2
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) the virus responsible for the COVID-19 global pandemic, spread around the world at an alarming rate. The transmission was of great concern, as was the ability of the virus to survive in the environment for extended periods of time. …
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Molecular Mechanisms and Host Factors Involved in HIV-1 Latency
The Human Immunodeficiency virus-1 can stay undetected and unaffected by host immune surveillance and antiretroviral therapy. This phenomenon is called proviral latency and the cells harbouring such viruses are part of the latently infected cell reservoir. In this situation, the viral genome …
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Persistent “hijacking” of brain proteasomes in HIV-associated dementia
Human immunodeficiency virus-1 (HIV) infection of the central nervous system results in a syndrome of neuropsychological impairment, motor deficits, and behavioral changes diagnosed as HIV-associated dementia. Findings of increased ubiquitin-stained deposits and high molecular weight …
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Anomalies of GABAergic system associated with HIV-1 infection
Human immunodeficiency virus-1 (HIV) infection of the central nervous system results in cognitive and behavioral dysfunctions diagnosed as HIV-associated dementia. Findings of lowered concentrations of γ-Aminobutyric acid (GABA) synthesizing enzymes in brains of HIV-infected patients suggest …
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The Therapeutic Role of LM11A-31 (a p75NTR Modulator) in the Outcome of Ischemic Stroke and HIV-1 Pathogenesis
… role of LM11A-31 in both ischemic stroke and human immunodeficiency virus-1 (HIV-1) infection. There are limited treatment options for ischemic stroke, with tissue plasminogen activator (tPA) being the only effective medication and a narrow administration window, which is also accompanied with …
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Gene expression from unintegrated HIV-1 is restricted by the SMC5/6 complex
… DNA into the host genome is the hallmark of human immunodeficiency virus 1 (HIV-1) infections. However, in early infection, the most abundant viral DNA species are extrachromosomal unintegrated viral genomes, which despite being competent for gene expression, are poorly expressed in the host …
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The effect of bacterial vaginosis on HIV infection
Human Immunodeficiency Virus-1 (HIV) and Bacterial Vaginosis (BV) are both among the most common diseases affecting young women in Sub-Saharan Africa. BV is characterised by dysbiosis in the female reproductive tract (FRT) when optimal Lactobacillus spp. such as L. crispatus, are displaced by …
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Assessing TMV as an immunogenic particle : the expression of HIV-1 subtype C V3 loop neutralizing antibody epitopes on the surface of TMV virions
In an attempt to establish a plant-based Human immunodeficiency virus-1 (HIV-1) subtype C neutralizing antibody stimulating vaccine, a Tobacco mosaic virus (TMV) derived vector was used to express recognized HIV neutralizing antibody epitopes. These epitopes were expressed on the surface of the TMV …
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The effect of HIV-1 Tat and methamphetamine on expression of cytokines/chemokines and synaptic genes: Implications in HIV neuroAIDS
Human immunodeficiency virus-1 (HIV-1) enters the brain through blood brain barrier (BBB) early after the infection and leads to various neurological complications including HIV associated dementia (HAD). Introduction of combined Anti Retro Viral therapy (cART) has significantly reduced the …
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The Role of Specific Integrase Strand Transfer Inhibitors (INSTIs) in the Alteration of Oligodendrocyte Maturation and Myelination in Hand
… thirty-seven million people are infected with human immunodeficiency virus-1 (HIV-1) worldwide. Thankfully, the development of combined antiretroviral therapy (cART) regimens has decreased mortality and significantly improved the overall quality of life for these patients. However, …
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DYSREGULATION of PROTEIN QUALITY CONTROL IMPAIRS FUNCTION of PRIMARY CARDIOMYOCYTES
… Furthermore, cardiovascular problems in HIV (Human immunodeficiency virus) positive patients whose viral load is controlled via antiretroviral therapy remains a problem while the underlying mechanism remains elusive. The current study has used an in vitro model of primary neonatal rat …
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Alcohol/HIV-Induced Neurodeficit and Circumvention by Neuroprotective Agent
… more limited. Alcohol use and infection with the Human Immunodeficiency Virus-1 (HIV-1) in the United States is relatively common, with 30 to 60 % of these individuals having AUDs. These patients are exposed to different viral proteins that are known to be neurotoxic in the central nervous system. …
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Causes and Consequences of Genetic Robustness and Fragility in HIV-1 Proteins
… maintain function in the face of mutation. RNA viruses, like human immunodeficiency virus-1 (HIV-1), experience extremely high mutations rates in vivo, which contribute to the evolvability that permits HIV-1 to evade immune defenses. However, the compact nature of the HIV-1 viral genome, in …
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Stepwise Reconstitution of RNA Cellular Activity
… among levels of reconstitution of the human immunodeficiency virus 1 (HIV-1) cellular process of transactivation. This process involves complex RNA-protein interactions between an HIV-1 RNA, the transactivation response element (TAR), and a complex of the viral Tat protein and host …
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