Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"Human immunity"”.
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Understanding Development of Human Immunity One Cell at a Time
… of the immune cells. The international Human Cell Atlas consortium has spearheaded and coordinated a global effort to construct atlases of human tissues across multiple developmental stages. This is revealing the identity and function of cells at unprecedented resolution and depth, …
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Algorithms for Understanding and Fighting Infectious Disease
… is a persistent and substantial threat to human health, with consequences that include widespread mortality, suffering, and economic disruption. This thesis presents several algorithmic advances that, when coupled with biotechnologies for data collection and perturbation, are aimed at …
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Language Models Predict Drug Resistance from Complex Sequence Variation
… key conceptual advance that viral escape from human immunity occurs in the event of a mutation which simultaneously generates meaningful antigenic change while also preserving viral fitness. These ideas are analogous to the semantics and grammar of a language. Theoretically, mutations that …
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Design and synthesis of polymers for Corona Phase Molecular Recognition (CoPhMoRe) of carbohydrates
… yet this recognition is the underpinning of human immunity, cell signaling, and glycobiology. For the past decade, significant effort has been made in this field to create new technologies to profile glycans and carbohydrates. Corona Phase Molecular Recognition (CoPhMoRe), the concept …
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Soy Isoflavone Supplementation Does Not Alter Distribution of Circulating Lymphocytes or Natural Killer Cell Activity in Postmenopausal Women
… the effect of soy isoflavone supplementation on human immunity in vivo. Establishing whether isoflavones affect immunity in aging adults is particularly relevant since compromised immune function has been observed in this population. Therefore, the purpose of this double-blind, …
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Gene Therapy and Stem Cell Therapy to Improve the Outcome of Human Islet Transplantation
… introduction in 1990s, the Edmonton Protocol for human islet transplantation has helped more than 500 patients with type 1 diabetes worldwide and met great success from bench to bedside. The Edmonton Protocol involves isolating islets from a cadaveric donor pancreas by enzymatic digestion and …
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Dissecting Human Antibody Responses Against Influenza A Viruses And Antigenic Changes That Facilitate Immune Escape
… allowing the virus to escape population immunity in a process known as antigenic drift. Due to antigenic drift, individuals can be repeatedly infected by antigenically distinct influenza strains over the course of their life. Antigenic drift undermines the effectiveness of our seasonal …
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Mechanistic modelling of the links between environment, mosquitoes and malaria transmission in the current and future climates of West Africa
… climate of West Africa. A mechanistic model of human immunity was incorporated into an existing agent-based model of malaria transmission, allowing us to move beyond entomological measures such as mosquito density and vectorial capacity to analyzing the prevalence of the malaria parasite within …
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The Genetic, Molecular, And Cellular Bases Of Unidentified Primary Immunodeficiencies
… immune system is inseparable from every part of human biology. From cell intrinsic mechanisms of pathogen recognition to multi-cellular interactions over vast ranges of time and space, the immune system is both essential for protection from infection and central to the pathogenesis of many …
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Monogenic Defects of the Type I Interferons Signaling Pathway in Humans: Molecular and Clinical Implications
… colloquially referred to as "germs" can invade humans or other hosts and cause disease, has remained the dominant conceptualization of infectious disease since the late nineteenth century. Since that time, growing appreciation for the extent of subclinical infections, that is, infections where …
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Human antibody-mediated immunity against infection and parasite fecundity in Schistosoma mansoni and Schistosoma haematobium infection
… against infection and reduce fecundity in human schistosome infections. The relative contribution of exposure to infection and IgE antibody responses against schistosomes were explored using a mathematical modelling approach. Age intensity and serology profiles of sub-cohorts were …
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Genomic investigation of primary immunodeficiency
… which effect one or more components of the human immune system and are typically considered monogenic. PID presents with features including increased susceptibility to infection, autoimmunity, autoinflammation, atopy and malignancy. The list of genes associated with these inborn errors of …