Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 26 for “"Human gut microbiota"”.
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Habitual gardening and the human gut microbiota
The student, Marina Brown, submitted this Thesis for approval on 2021-07-20 at 14:08.
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Effects of Brassica on the human gut microbiota
… associated with potential health benefits for humans. Glucosinolates are metabolised in the gut by members of the gut microbiota, producing biologically active breakdown products, such as isothiocyanates. The effects of consuming Brassica on the composition of the gut microbiota, and the …
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Aromatic Amino Acid Metabolome In The Human Gut Microbiota
… common substrates are key candidates for host-microbiota crosstalk due to the potential for convergent biosynthetic pathways. Several human signaling molecules are simple structures derived from aromatic amino acids (phenylalanine, tryptophan, and tyrosine). In this thesis, I employed targeted …
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Dynamics of the human gut microbiota in very early life
… mediated through perturbation of the infant gut microbiota colonisations. However, the impact of modern clinical practices, such as caesarean-section delivery and antibiotic usage, on the earliest stages of gut microbiota acquisition and development during the neonatal period (≤1 month) …
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Characterization of Human Gut Microbiota Dynamics Using Model Communities in Gnotobiotic Mice
<p>The human gut is colonized by a diverse array of microbes, collectively referred to as the microbiota. The microbiota's complexity poses significant challenges in characterizing the rules dictating its assembly, inferring the functional roles of its component species, and understanding how …
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Functional metagenomic analysis of carbohydrate degrading enzymes from the human gut microbiota
Abstract The gut microbiota is a complex and diverse microbial community that is adapted to a carbohydrate-rich ecosystem. Plant cell wall components (cellulose, hemicelluloses and pectins), resistant starch and various oligosaccharides reach the colon by escaping digestion in the upper …
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Functional Genomic Examinations Of Interactions Between Common Members Of The Human Gut Microbiota
The adult human gut microbiota consists of hundreds to thousands of bacterial species, the majority belonging to the Bacteroidetes and the Firmicutes. Differences in the balance between these phyla has been linked to obesity in mice and humans. However, little is known about their interactions in …
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Physical activity for health: the impact of exercise on the human gut microbiota and pro-inflammatory cytokines
… exercise and associated diet on the intestinal microbiota. To do so we used a combination of systematic review, randomized control trials, and prospective observational analyses. Results: Relating to the impact of exercise on the gut microbiome, this work suggests that favourable microbial …
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Engineering the human gut microbiome through personalized dietary interventions
The human gastrointestinal tract is home to a dense and dynamic microbial community. The composition and metabolic output of the human gut microbiota have been implicated in many diseases: from inflammatory bowel disease, colorectal cancer, and diarrheal diseases to metabolic syndromes like …
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Influence of Enteric Microbiota on Human Rotavirus and Human Norovirus Infection, and Rotavirus Immunity in Gnotobiotic Pigs
Enteric microbiota influences enteric viral infections, and host response to these pathogens and vaccines. Using gnotobiotic (Gn) pigs transplanted with human gut microbiota (HGM), we studied the effects of HGM on the immune response to oral rotavirus vaccination and rotaviral disease. We also used …
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Metagenomic Analyses of the Human Gut Virome
<p>The human gut harbors tens of trillions of microbes belonging to all three domains of life, Bacteria, Archaea, and Eukarya; most are members of Bacteria. These organisms collaborate and compete for functional niches and physical space: habitats), together forming a continuously functioning …
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Effects of different antiretroviral treatments on gut microbiota of hiv-infected patients
The human gut microbiota has a symbiotic relationship with the host and plays a crucial role in the maintenance of health. HIV infection has been associated with a disturbance in gut microbiota (dysbiosis). Increased bacterial translocation and alterations to gut microbiota composition have been …
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Exploring the impact of gastrointestinal parasitic helminths on the human microbiome using advanced biomolecular and bioinformatics technologies
Our understanding of the biology of human gastrointestinal (GI) parasitic helminths is greater than ever before. However, so far, the research has focused on gene expression profiling, immune- and protein-protein interactions in host-parasite systems. The importance of parasite microbiota …
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Antibiotic resistance in the gut microbiota
… understanding the effects of antibiotics on the gut microbiota, as well as the potential for such populations to act as a reservoir for resistance genes, is imperative. This thesis set out to investigate the gut microbiota of antibiotic treated infants compared to untreated controls using …
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The relationship between enteral nutrition, energy metabolism and gut homeostasis during the course of critical illness.
… influencing the composition and activity of the human gut microbiota. The aim of this PhD project was to investigate the effect of nutrition as a factor affecting the intestinal microbiome-host relationship in critically ill children and whether it has an impact on clinical disease severity. The …
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Constraint-based modeling of host-microbe and microbe-microbe metabolic interactions in the human gut
Humans harbor a complex microbial ecosystem in their intestines. This human gut microbiota performs essential functions for host health and wellbeing. Disruption, or dysbiosis, in gut microbiota composition has been directly linked to the pathogenesis of complex diseases. Understanding the …
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Effects Of Diet And Parasites On The Gut Microbiota Of Diverse Sub-Saharan Africans
ABSTRACT EFFECTS OF DIET AND PARASITES ON THE GUT MICROBIOTA OF DIVERSE SUB-SAHARAN AFRICANS Meagan A. Rubel Sarah A. Tishkoff Contemporary African populations possess myriad genetic and phenotypic adaptations to diverse diets, varying climates, and infectious diseases. Most microbiome studies to …
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The gut microbiota in immune-mediated disorders
The human gut microbiota is a diverse community of microbes residing in the intestine. Evidence from various animal models and human studies have highlighted its potential role in health, metabolic and immune-associated conditions such as osteoporosis, inflammatory arthritis, inflammatory bowel …
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The microbiota and colon cancer risk: cause or consequence?
… attention has turned to the influence of the gut microbiota upon the development of CRC. The human gut microbiota is altered in CRC and certain microbial patterns are associated with increased cancer risk, but definitive identification of mechanisms and specific bacteria involved has proven …
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High-Throughput Discovery of Stimuli of Bacterial Two-Component Systems from the Human Gut Microbiome
The human gut microbiota is a dense and diverse community of bacteria that interact with the host and have major impacts on health and disease. Two-component systems (TCS) are the primary means by which bacteria, including those in the gut microbiome, sense and adapt to their environment. The …
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