Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 93 for “"Human gut"”.
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Metagenomic Analyses of the Human Gut Virome
<p>The human gut harbors tens of trillions of microbes belonging to all three domains of life, Bacteria, Archaea, and Eukarya; most are members of Bacteria. These organisms collaborate and compete for functional niches and physical space: habitats), together forming a continuously functioning …
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Habitual gardening and the human gut microbiota
The student, Marina Brown, submitted this Thesis for approval on 2021-07-20 at 14:08.
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Evolutionary dynamics of the human gut microbiome
The composite members of the human gut microbiome encounter a myriad of selective pressures from the host environment and other microbial members in the ecosystem. Understanding the evolutionary dynamics of microbial species in the gut microbiome requires sequencing information that differentiates …
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Complex glycan utilization preferences of human gut bacteria
… In order to investigate how the members of our gut microbiota utilize glycans and activate their respective polysaccharide utilization loci (PULs), we performed a series of time-course assays in which two model organisms, Bacteroides thetaiotamicron (Bt) and B. ovatus (Bo), were individually …
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Effects of Brassica on the human gut microbiota
… associated with potential health benefits for humans. Glucosinolates are metabolised in the gut by members of the gut microbiota, producing biologically active breakdown products, such as isothiocyanates. The effects of consuming Brassica on the composition of the gut microbiota, and the …
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Interactions between salmonella typhimurium and human gut bacteria
… is an important enteropathogen that causes human morbidity and mortality worldwide. It is essential to study the interaction between Salmonella and the gut bacteria to elucidate the elements that influence the ability of the pathogen to overcome the colonisation barrier mediated by the gut …
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Predicting Colonization of Microbes in the Human Gut
<p>The human gut is home to trillions of microbes that interact intimately with the host and its diet. An important emergent phenotype by these microbes is colonization resistance, the process by which a microbial community resists colonization of an exogenous microbe. This resistance barrier is …
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Interactions of Environmental Pollutants with Human Gut Bacteria
… make it into the food and hence into the human body. While pharmaceutical drugs have been shown to have a strong impact on the human gut microbiota both in vitro and in vivo, relatively little is known about the effects of other compounds, such as pesticides, processing contaminants and …
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Aromatic Amino Acid Metabolome In The Human Gut Microbiota
… for convergent biosynthetic pathways. Several human signaling molecules are simple structures derived from aromatic amino acids (phenylalanine, tryptophan, and tyrosine). In this thesis, I employed targeted and untargeted mass spectrometry-based approaches to identify novel bacterial …
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The impact of microgravity conditions on human gut microbiome
The human gut microbiome plays a fundamental role in maintaining overall health by regulating metabolism, immune function, and neurological processes. Disruptions to its balance can lead to various health complications. Space exploration introduces unique environmental challenges, particularly …
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RNA regulation of polysaccharide metabolism in human gut Bacteroidetes
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2022-11-11 without embargo terms
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Engineering the human gut microbiome through personalized dietary interventions
The human gastrointestinal tract is home to a dense and dynamic microbial community. The composition and metabolic output of the human gut microbiota have been implicated in many diseases: from inflammatory bowel disease, colorectal cancer, and diarrheal diseases to metabolic syndromes like …
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Diversity of the butyrate-producing microflora of the human gut.
… products of bacterial fermentations in the human colon and is the preferred energy source of the colonic epithelial cells in a healthy colon (Roediger, 1980). Potential protective roles have been suggested for butyrate as an anti-cancer and anti-inflammatory therapeutic treatment for the …
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Dietary Manipulation of Metabolic Function in the Human Gut Microbiome
<p>The human gut microbiome is increasingly recognized as having a causal or contributing role in a wide variety of diseases. While mechanisms by which the microbiome contributes to or triggers disease processes are myriad, short-chain fatty acid (SCFA) production has been found to be a powerful …
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Steroid metabolism in the human gut by microbial hydroxysteroid dehydrogenases
… that are important signaling molecules in the human body. Bile acids are essential for nutrient solubilization and absorption in the gut while cortisol is involved in stress response and metabolism throughout the body. The gut microbiome has evolved a network of enzymes that modify steroids …
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Dynamics of the human gut microbiota in very early life
… mediated through perturbation of the infant gut microbiota colonisations. However, the impact of modern clinical practices, such as caesarean-section delivery and antibiotic usage, on the earliest stages of gut microbiota acquisition and development during the neonatal period (≤1 month) …
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Mobile genetic elements as modulators of the human gut symbiont Bacteroides
… of the most common and abundant microbes in the human gut, exploration of MGE diversity is incomplete. Given the genus’s dominance in the gut, we postulate Bacteroides MGEs may play an oversized role in how the gut microbiome functions and interacts with the human host. In Chapter 2, I present …
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Integrative Analysis of the Human Gut Phageome Using a Metagenomics Approach
… microbial communities. Given the impact of the gut microbiome composition and function on human health, there is a growing focus on phages that inhabit the gut ecosystem. However, the extent of viral diversity, biology, and worldwide epidemiology of gut phages remain largely unknown. In this …
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Structural characterization of glycyl radical enzymes in the human gut microbiome
Anaerobic bacteria play important roles in the human gut microbiome and have dedicated chemical pathways for growth in the absence of oxygen. Glycyl radical enzymes (GREs) use an oxygen-sensitive glycyl radical cofactor to perform challenging, radical-based chemistry. Generation of this cofactor …
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Characterization of Human Gut Microbiota Dynamics Using Model Communities in Gnotobiotic Mice
<p>The human gut is colonized by a diverse array of microbes, collectively referred to as the microbiota. The microbiota's complexity poses significant challenges in characterizing the rules dictating its assembly, inferring the functional roles of its component species, and understanding how …
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