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Showing 1 to 20 of 21 for “"Human growth hormone"”.
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Thiol-Disulfide Exchange in Human Growth Hormone
… this goal, model peptides derived from human growth hormone (hGH) and intact hGH were used to investigate reaction mechanisms and kinetics in solution and solid-state environments. The results will be useful in the rational development of stable, safe and efficacious protein formulations …
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Resolving the Role of POU1F1 in Human Growth Hormone Locus Activation
The human growth hormone gene ( hGH-N) is regulated by a distal locus control region (LCR) composed of five deoxyribonuclease I hypersensitive sites (HSs). The region encompassing HSI and HSII contains the predominant pituitary somatotrope-specific hGH-N activation function of the LCR. This …
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Scanning electrochemical microscopy for the investigation of biosensors /
… of experiments involved the detection of the human growth hormone by electrochemical means. The antibodies against the human growth hormone were labelled with glucose oxidase which was detectable with the scanning electrochemical microscope in a solution containing glucose. The human growth …
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Effects of GH on the IGFs and IGFBPs in children with chronic renal failure and transplantation
… retrospective investigation of the insulin-like growth factors and their binding proteins in the serum of children with chronic renal failure (CRF) and transplantation, before and after treatment with recombinant human growth hormone (rhGH). IGF-IGFBP complexes in pooled serum from prepubertal …
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Metabolic and hormonal responses in the regulation of blood glucose levels in infants delivered by elective caesarean section
… enzyme system in animal studies, in adult humans, and studies of cell lines make the possible failure of hormonal control around the time of birth an important hypothesis to test, but before this can be done, further studies of perinatal metabolism and its hormonal control need to be …
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An audit of endocrine dysfunction in children with craniopharyngiomas at Red Cross Children's Hospital and Groote Schuur Hospital from 1976 to 2004
… were ACTH and TSH deficient and only 38% were growth hormone deficient. After surgery multiple endocrinopathies were universal with 56% of children having pan hypopituitarism at follow up. There was no reversal of pre-existing hormone deficits after surgery. The management of craniopharyngiomas …
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Integrated microbioreactor arrays for high-throughput experimentation
… role in producing biopharmaceuticals such as human insulin and human growth hormone, and other products such as amino acids and biopolymers. Because bioprocesses involve the complicated interaction between the genetics of the microorganisms and their chemical and environmental conditions, …
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Biochemical aspects of the idiopathic respiratory distress syndrome of the newborn
… Interrelationships between α-fetoprotein, Human Growth Hormone and other proteins, in immunochemical systems were investigated. In summary, the main conclusions reached were as follows: (i) The total serum-protein concentration in affected infants is much reduced, as compared with healthy …
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ENGINEERING WATER-SOLUBLE VARIANTS OF THE SINGLE-SUBUNIT OLIGOSACCHARYLTRANSFERASE
… the amphipathic protein including engineered human apolipoprotein A-I. Using E. coli culture as an expression platform, several SIMPLEx-OSTs could be expressed within the cytoplasmic fraction of the E. coli. Importantly, our engineered OSTs retain their biological activity and are able to …
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Carbon nanotube-based sensors for label-free protein detection
… platform is then extended to the detection of human growth hormone (hGH) using SWNT functionalized with a native hGH receptor (hGH-R), with potential use as a real-time and label-free measurement of protein activity. Native hGH is detected in the micromolar range, and an invariant equilibrium …
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Aspects of lactation endocrinology: I. lactogenic receptors in bovine mammary tissue at different stages of lactation: II. growth hormone concentrations in Holstein cattle of differing genetic merit
… The Kd was 100-fold greater when estimated with human growth hormone as competitor. It is concluded that lactogenic hormone receptor concentrations in bovine mammary tissue increase with the onset of lactation, following a pattern similar to that observed in non-ruminants. Three experiments were …
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Site-Specific Genome Engineering in Mouse Primary Fibroblasts
… performing site-specific genome engineering in human cell lines and primary cells, including embryonic stem cells, induced pluripotent stem cells and CD34+ hematopoietic stem cells. However, very little has been accomplished in terms of animal modeling of these principles. The work described in …
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Site-Specific Genome Engineering in Mouse Primary Fibroblasts
… performing site-specific genome engineering in human cell lines and primary cells, including embryonic stem cells, induced pluripotent stem cells and CD34+ hematopoietic stem cells. However, very little has been accomplished in terms of animal modeling of these principles. The work described in …
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The effect of combining a Wingate sprint with circuit weight training on growth hormone in response to exercise.
Human growth hormone (HGH) in response to resistance training has been suggested to be correlated with the muscle hypertrophy adapted to resistance training. The purpose of this study was to investigate whether or not adding a Wingate sprint to a circuit weight training session would optimize the …
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An Update on Pharmaceutical Strategies for Oral Delivery of Therapeutic Peptides and Proteins
<p>Peptides and proteins are imperative for the human body and play crucial roles in governing various bio-chemical processes. Recent advances in molecular biology and biochemistry helped in understanding the role of these endogenous macromolecules in different pathological and disease conditions. …
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Growth hormone metabolism in hypopituitary subjects and young, middle-aged and elderly normal subjects
The purpose of these studies was to determine if human growth hormone (hGH) metabolism declines with advancing age. Twenty-two subjects' responses to the hGH provocative tests of exercise, L-DOPA, and insulin, hGH peak concentrations during sleep, and 24-hour integrated concentrations (ICGH) during …
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Sporopollenin exines as a novel drug delivery system
… of substances into sporopollenin exines, such as human growth hormone (hGH) , Enfurvitide (an antiretroviral agent used in the treatment of AIDS) and Cyclosporine (an antifungal agent). Their successful release from exines into different media in vitro and in vivo (carried out in Beagle dogs) was …
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Examining Causal Determinants of Childhood Obesity and Pubertal Timing
… the associations between eating behaviour and growth across infancy and childhood. Using the Children’s Eating Behaviour Questionnaire (CEBQ), I assessed eight appetitive traits—four food-approach and four food-avoidant traits—against growth velocities including weight, length/height, BMI, and …
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Mid-IR Imaging and Multivariate Analysis of Dynamic Processes in Pharmaceutically Relevant Microparticles
… to monitor the redistribution and release of human growth hormone (hGH) from a range of CriticalMixTM processed PLGA/PLA microparticles during a set of dissolution experiments at 37 °C in D2O. Increasing the γ dose is shown to have a profound influence on the release mechanism, with higher γ …
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